15 more COVID-19 research projects receive funds from Houston university

coronavirus solutions

Rice University identified 15 more pandemic-related research projects to receive support from a new research fund. Getty Images

Researchers at a Houston institution have been rewarded for their work that focuses on COVID-19 and how it's affected various aspects of life.

Rice University has named its two more rounds of recipients of its COVID-19 Research Fund — an initiative created to support projects that are innovating solutions and services amid the COVID-19 crisis. In April, the COVID-19 Research Fund Oversight and Review Committee — led by engineering professor and special adviser to the provost, Marcia O'Malley — selected four projects led by Rice faculty members across industries from biomedicine to humanities that will receive the first round of funds.

The committee named another round of recipients in May and the third and final round this month. Here are the projects from the last two rounds of grants:

  • Rapid point-of-care device to detect severe cases of COVID-19 by Kevin McHugh and Peter Lillehoj of Rice and Cassian Yee of the University of Texas MD Anderson Cancer Center.
  • A mobile phone-based blood serum test for COVID-19 antibodies by Lillehoj, Wen Hsiang Chen of Baylor College of Medicine and James Le Duc of Galveston National Laboratory. The mobile test would be faster and more precise.
  • A handbook addressing pandemic response initiatives for health officials by Kirsten Ostherr and Lan Li of Rice; Thomas Cole of the McGovern Medical School at the University of Texas Health Science Center, Houston; Robert Peckham of Hong Kong University; and Sanjoy Bhattacharya of York University.
  • A look at COVID-19's effect on vehicle travel and electric power generation and air quality by Daniel Cohan and Daniel Kowal of Rice. Using both on-the-ground and satellite data, the researchers will look at various air pollutants.
  • A study on Harris County residents' compliance to stay-at-home orders by Flavio Cunha, Patricia DeLucia, Fred Oswald, Ekim Cem Muyan and E. Susan Amirian of Rice. The researchers will survey residents — particularly low-socioeconomic populations.
  • A look at how pollution and economics affect each other turing a pandemic-caused crisis by Sylvia Dee, Ted Loch-Temzelides, Caroline Masiello and Mark Torres of Rice. Thanks to stay-at-home initiatives, the study can look at which economic sectors contribute the most to carbon emissions.
  • A study on long-term effects of COVID-19 on human development by Fred Oswald of Rice, Rodica Damian and Tingshu Liu of the University of Houston and Patrick Hill of Washington University. The project looks at the pandemic's affect on social contexts including occupational, educational, community, family, lifestyle, health and financial.
  • A predictive model of Houston's COVID-19 condition by Daniel Kowal, assistant professor of statistics, and Thomas Sun, a graduate student, at Rice. The project will compare Houston to locations that are similar and further along the disease incidence curve.
  • A survey of how stay-at-home orders affected low-income families by Amelyn Ng, Wortham Fellow at Rice Architecture, and Gabriel Vergara of One Architecture and Urbanism. he survey will focus on Houston's Greater Fifth Ward.
  • Research on antibodies for disease prevention by Laura Segatori, associate professor of bioengineering and of chemical and bimolecular engineering and biosciences, and Omid Veiseh, assistant professor of bioengineering, at Rice. The two scientists plan to engineer cell lines for the rapid development of clinically translatable neutralizing antibodies for infection control.
  • An analysis of working conditions amid the pandemic by Danielle King, assistant professor of psychological sciences at Rice. King will look into both employees who can no longer go to the workplace, like teachers, and those required to, like nurses, to see what resources are most effective.
  • An oxygen sensing device by Michael Wong, department chair and a professor of chemical and biomolecular engineering, and Rafael Verduzco, associate professor of chemical and biomolecular engineering, of Rice and John Graf of NASA. The team will continue working on a NASA-designed prototype ventilator for rapid deployment based on an off-the-shelf automotive oxygen sensor.
  • A study on social distancing for musicians by Ashok Veeraraghavan, Robert Yekovich and Ashutosh Sabharwal of Rice and John Mangum of the Houston Symphony. The project will look into airflow of wind instruments using high-speed imaging.
  • Looking into public health initiatives and their use in COVID-19 by Hulya Eraslan, Rossella Calvi, Dibya Deepta Mishra and Ritika Sethi of Rice. The team will look at election data with a goal is to understand the impact of political alignment across levels of government on the effectiveness of its response.
  • Research on optimizing nursing staff schedules by Andrew Schaefer, Illya Hicks and Joseph Huchette of Rice and Nicole Fontenot of Houston Methodist Hospital. Researchers will employ data and technology to improve forecasting demand for nursing staff.
Four COVID-19-focused research projects have been selected by Rice University to receive funding. Photo courtesy of Rice University

Houston university announces first recipients of coronavirus research funding

covid heroes

Rice University has named several Houston researchers as recipients of funding as a part of a new initiative to support projects that are innovating solutions and services amid the COVID-19 crisis.

The university's COVID-19 Research Fund Oversight and Review Committee — led by engineering professor and special adviser to the provost, Marcia O'Malley — selected a few projects led by Rice faculty members across industries from biomedicine to humanities that will receive the first round of funds. However, the application window is ongoing, according to a press release, and additional awards are to be expected.

Here were the first projects and researchers to be selected by the committee.

A low-cost diagnostic tool

Rice researchers Rebecca Richards-Kortum and Kathryn Kundrod of Rice University along with Kathleen Schmeler of the University of Texas MD Anderson Cancer Center have identified a way to create a COVID-19 diagnostic device that costs less than $5,000 and less than $2 per test. It would also take fewer than 30 minutes to diagnose.

The researchers are also working with USAID and industry partners on a plan to scale the test to five countries in Africa. In the future, the device would enable broader SARS-CoV-2 testing locally and in low- and middle-income countries.

Richards-Kortum is a professor of bioengineering and electrical and computer engineering and director of Rice 360˚. Kundrod is a graduate student in bioengineering. Schmeler is a professor in the department of gynecologic oncology and reproductive medicine at MD Anderson.

A protective rubber harness to be worn over a face mask 

Jacob Robinson and Caleb Kemere, associate professors at Rice, along with Sahil Kuldip of MD Anderson, have discovered a low-cost, easy-to-manufacture rubber harness to be worn over surgical or cloth masks in order seal the masks. The seal would better prevent small airborne particles from getting around the masks.

Robinson is in Rice's electrical and computer engineering and bioengineering departments, while Kemere specializes in electrical and computer engineering. Kuldip is an assistant professor of plastic surgery at MD Anderson.

Wastewater monitoring for coronavirus contamination 

Rice researchers Lauren Stadler, Katherine Ensor and Loren Hopkins are working with the Houston Health Department and Houston Water on a plan to collect wastewater samples from local treatment plants to monitor for the presence of COVID-19.

With most people asymptomatic or experience only mild symptoms of COVID-19, the researchers are looking into the virus's presence in wastewater in order to track community infection.

Stadler, an assistant professor of civil and environmental engineering, and Ensor, the Noah G. Harding Professor of Statistics, are working with Hopkins, who is a professor in practice of statistics and chief environmental science officer for the Houston Health Department.

The identification of safe and healthy voting procedures 

Five Rice researchers — Robert Stein, Philip Kortum, Claudia Ziegler Acemyan, Daniel Wallach and Elizabeth Vann — are looking into steps Harris County can take to ensure that in-person voting is safe and keeps participants healthy. Through surveys with citizens, the team will help election officials survey both voters and poll workers on their voting preferences and concerns.

The research team spans campus departments: Stein is the Lena Gohlman Fox Professor of Political Science, Kortum is an associate professor of psychological sciences, Acemyan is an adjunct assistant professor of psychological sciences, Wallach is a professor of computer science and of electrical and computer engineering, and Vann is the director of programs and partnerships at the Center for Civic Leadership

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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