Trivie, which gamifies corporate training, has launched a new way for employees to connect with remote learning amid the pandemic. Photo via Trivie.com

How much of corporate training do employees actually remember? Texas-based Trivie, a training reinforcement app, sought to not only answer that question, but change the results entirely. Using adaptive learning and gamification, the Trivie app is reshaping online learning while the world adapts to remote working in a global pandemic.

According to Gallup Panel data, 62 percent of Americans currently say they have worked from home during the coronavirus pandemic. In a connected yet socially distanced environment, corporations are choosing to automate remote learning and disseminate critical COVID-19 guidelines with the help of Trivie.

One of Trivie's founders, Leland Putterman, who is based in Houston, first had the idea for a consumer-facing trivia game 18 years ago. When the app rolled out in 2013, it garnered more than three million downloads. Like anything in technology, App Store games were diversifying. Competing applications were deviating into in-app purchases — a move Putterman's app hadn't planned.

Rather than sink under the pressures of an unfit revenue model, the founders pivoted to a more fruitful investment in an untapped space: corporate training. After receiving multiple emails from users asking if developers had ever thought of using the app for company training, Putterman jumped into research on information retention and learned that trivia vastly benefits human memory.

With a new business plan and research backed by neuroscientists, the Trivie app launched in 2016. Reaching a broad list of organizations with five to over 40,000 users, Trivie has generated the praise and trust of business goliaths such as Subway, Unilever, and Anheuser-Busch. The app has been used to roll out onboarding, marketing training, safety protocols, sales information, remote learning and more.

"The vast majority of companies and organizations do nothing after a training event," he says, adding that, according to Trivie's own research, the app has found 50 to 75 percent of people had forgotten workplace education within a month. "It makes training one of the least effective business processes out there because everybody knows people don't remember their training unless it gets reinforced."

What if the secret to remembering is forgetting? Studies have shown that re-learning information over time strengthens memory recall.

"The way our solution works is very unique in that we want you to forget so you can re-remember again. The process of re-remembering is what pushes things into durable memory," explains Putterman.

When a company sets up a training on the Trivie app, the program serves each employee personalized training refreshers over time that are balanced with the retention levels of each unique learner. Using adaptive learning, the app prompts employees to remember previous facts until they master the subject.

"The AI [artificial intelligence] on the backend predicts when you're going to forget again, and it automates the whole thing," Putterman says.

In a Trivie control group, half of the test subjects used Trivie and half received basic employee training. Putterman stated the Trivie users typically have 95 percent retention after a month while non-Trivie users show less than 60 percent retention.

Employers can see the results of each Trivie assessment, pinpointed down to individual questions — a feature that is especially crucial for compliance and safety protocol. One of Trivie's university clients published a training on Title IX, where students passed yet 65 percent missed the question: "Whose responsibility is it to gain consent during a sexual encounter?"

When the university received the results, "they were able to see down to that level of detail—and that knowledge gap is pretty darn important," explains Putterman.

"Training is important but nowadays it's mission-critical," he says.

While Trivie already had many clients with needs for safety training, COVID-19 has brought new compliance guidelines to the forefront of every industry. Currently, Trivie has made the CDC's coronavirus guidelines available to all of its clients for no additional charge to be used across their entire employment bases.

Putterman acknowledges the pitfalls of sending out a corporate memo only to hear crickets.

"In a Trivie platform you would send a video, PDF, or word document via Trivie. You'd know people opened it up and after they're required to take a quiz so you know they understand what was in the message," Putterman explains.

An internal discussion board also allows company employees to discuss why the communication is essential to the organization. Another prominent feature of the app is a customizable survey.

"You know as well as I do that there's a ton of anxiety out there [about the coronavirus]. Wouldn't it be nice to push out a survey and then have a discussion around how people are dealing with it?" he questions.

With most of America's workforce working from home, Putterman expressed that it's common for employees to feel disconnected.

"The only way to maintain that company culture and close communication with confidence is to use something like Trivie," he says. "There's no feedback loop right now. The only way to bridge that gap is to have something like Trivie that's the glue."

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."