The Corporate of the Year category for the Houston Innovation Awards has four finalists — each playing a role in Houston's innovation ecosystem across energy, tech, and health care innovation. Photos courtesy

What corporations are most supporting Houston's startup ecosystem? The Houston Innovation Awards sought to find that out with a new category for the 2023 event.

The Corporate of the Year category has four finalists — each playing a role in Houston's innovation ecosystem across energy, tech, and health care innovation. Learn about each of these finalists in the interviews below.

Click here to secure your tickets to the November 8 event where we announce the winner of this exciting new category.

Aramco Ventures

Jim Sledzik, North American managing director of Saudi Aramco Energy Ventures, leads the organization locally. Photo via Aramco

Describe your company's work within the Houston innovation ecosystem.

Aramco Ventures has supported the development of Houston's innovation ecosystem as a founding member of the Ion to advance energy transition and Houston's tech economy. Jim Sledzik, managing director, Aramco Ventures North America, serves on the Ion Advisory Council. In addition we support Greentown Labs with its offices in Boston and Houston with Sledzik also named to its Advisory Board. Aramco Venture professionals are frequently tapped as speakers and participants for numerous industry speaking events and "Pitch Competitions" for start-up companies. For example, the 20th Annual Energy Tech Venture Forum held in Houston and organized by the Rice Alliance for Technology and Entrepreneurship; Climate Week NYC; and the first ever Women's Capital Summit in New York City.

Why has your company decided to support the Houston innovation ecosystem?

Houston is considered the energy capital of the world and Aramco's support and involvement will help amplify the city's reputation and presence as a global energy hub.

Describe your company's impact on the Houston innovation ecosystem.

Aramco's impact has been felt throughout the city by our involvement in major innovation events, activities, and investments.

Chevron Technology Ventures

Jim Gable, vice president of innovation at Chevron and president of Chevron Technology Ventures, leads the organization locally. Photo courtesy

Why has your company decided to support the Houston innovation ecosystem?

Investing in the communities where we operate is a core Chevron value, and Chevron is committed to building the innovation ecosystem in Houston. It’s good for our company and it’s good for the city.

The Houston region, with its deep pool of engineering and industry talent, world-class university expertise, growing startup community and vast energy infrastructure, is well-positioned to lead in the creation of lower carbon energy and improve the region’s global competitiveness. By leveraging its strengths, Houston can create its own model for how it’s going to disrupt the energy space.

Describe your company's impact on the Houston innovation ecosystem.

At Chevron Technology Ventures, we leverage our trial and deployment resources, venture investments and strategic partnerships – both internal and external – to support the technological breakthroughs that will enable the evolution to a lower-carbon energy system. CTV is an active sponsor of university programs and accelerators that build up the Houston energy ecosystem. It has led Chevron’s founding partnership with Greentown Labs Houston and was The Ion’s first tenant and program partner. CTV also backs The Cannon and Rice Alliance Clean Energy Accelerator, among others. As a partner and supporter of the innovation ecosystem, Chevron is committed to helping the ecosystem thrive.

Houston Methodist

Michelle Stansbury, vice president of innovation and IT applications at Houston Methodist, leads the company's innovation efforts. Photo courtesy of Houston Methodist

Describe your company's work within the Houston innovation ecosystem.

Our new collaborative space, the Tech Hub at Ion, is one way we are expanding our culture of innovation within Houston and its growing innovation ecosystem. Beyond showcasing ongoing technology, the Tech Hub at Ion also serves as a nucleus for community engagement and networking and hosting educational initiatives, with additional programming opportunities like reverse pitch sessions in the works.

Why has your company decided to support the Houston innovation ecosystem?

Healthcare is evolving at a rapid pace thanks to digital technology, so it’s important to search for solutions that are beyond the traditional walls of the hospital and even beyond our own industry. Serving our patients both in and outside the walls, especially in the community, has been a priority for Houston Methodist since our inception. We’ve had success in the healthcare innovation space, so we think it’s important to pay it forward and support the Houston innovation community.

Describe your company's impact on the Houston innovation ecosystem.

Our new collaborative space, the Tech Hub at Ion, is one way we are expanding our culture of innovation within Houston and its growing innovation ecosystem. Beyond showcasing ongoing technology, the Tech Hub at Ion also serves as a nucleus for community engagement and networking and hosting educational initiatives, with additional programming opportunities like reverse pitch sessions in the works. Houston Methodist’s Center for Innovation often collaborates with technology companies with solutions that provide a better patient experience and/or support clinicians and often these are technology companies early in their start-up journey. One Houston start-up Houston Methodist at the beginning of the pandemic and continues to use is MIC Sickbay, the technology that powers the virtual ICU and uses algorithms and AI to monitor patients.

Microsoft

Rob Schapiro, Energy Acceleration Program director and Houston site leader for Microsoft, leads the company's local innovation support efforts. Photo courtesy of Microsoft

Describe your company's work within the Houston innovation ecosystem.

Microsoft is committed to driving tech and innovation in the Houston community with a specific focus on underrepresented communities. Microsoft is financially supporting the ion, Greentown Labs Accel, DivInc, Tejano Tech Summit, and the Rice Alliance Clean Energy Accelerator as well as programs designed to bring the next generations of Houston founders to the forefront (G-Unity Business Lab, SuperGirls Shine Foundation, Tech Fest Live, PVAMU). Aside from the financial support, Microsoft brings a dedicated team of volunteers and mentors to each of these engagements, and they are helping shape the future of innovation in the city of Houston.

Why has your company decided to support the Houston innovation ecosystem?

We believe that it is our duty to be an active and engaged corporate partner to any and all communities in which we operate. We decided to invest in Houston because of the rich, diverse talent pool and the growing energy transition industry.

Describe your company's impact on the Houston innovation ecosystem.

  • Partnered with DivInc to create an Energy Tech Accelerator program that had its first cohort of seven companies this year.
  • Driving thought leadership and bringing attention to valuable initiatives through serving on the advisory boards of the Ion (Vice Chair position), Greentown Labs Houston, Rice Alliance Clean Energy Accelerator.
  • Supporting the next generation of innovators: 120 high school students received hands on training in innovation and prototyping as part of the G-Unity Business Lab. This program doubled in size due to its success. Microsoft sponsored prototyping and design thinking training. We also seated one of the Hustle Tank judges.
  • Graduated 14 students from the Level Up fellowship program in partnership with Prairie View A&M University and Accenture; most students received and accepted employment offers from Accenture.
  • Sponsored 20 high school girls who participated in the SuperGirls Shine Foundation's 40/40 mentorship program.
  • Ten women founders received mentoring and training as part of the DivInc Women in Tech Cohort
  • Held a four-week high school internship program for BIPOC students

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.