A panel for women by women highlighted key things to keep in mind when starting a company. Getty Images

Laying the proper foundation of a startup might be one of the most important parts of starting a company — right behind the innovative solution your startup aims to provide.

At a female-founder focused panel at Baker Botts cohosted by The Artemis Fund earlier this month, a group of experts gave their advice from managing contracts and hiring to salary and investment.

The panel was moderated by Grace Rodriguez, CEO and executive director of Impact Hub Houston, and featured an investor, a founder, and a legal representative — Leslie Goldman, general partner and co-founder of The Artemis Fund; Emma Fauss, CEO of Medical Informatics Corp.; and Katie Belleville, associate at Baker Botts L.L.P, respectively.

If you missed the event, here are four pieces of advice from the panelists.

Be aware of an investor's founder red flags

When asked about what she looks for in a potential investment opportunity, Goldman, who's fund invests in female-led startups, looks at a myriad of things, but the big one is the founder herself.

"Ninety percent of it is about the founder," Goldman says on the panel. "The founder is key."

She goes on to say that her founder red flags include lack of transparency, not knowing her numbers, and not having the proper legal paperwork in order.

Representing the legal side, Belleville echoed the importance of getting the proper legal paperwork together from day one.

"It is important to get you organizational documents in order in the beginning to avoid a problem later down the line," Belleville says. "Going to a lawyer to help you set up your company and what documents you need."

She adds that startup founders can expect to pay lawyers by the hour like most legal exchanges, but a lot of legal professionals will offer a preliminary meeting to understand each other for free.

Be smart about who's giving you money

For Fauss, who closed an $11.9 million round in January, and most entrepreneurs, finding investors is a huge challenge and commitment.

"Raising money is probably my least favorite activity. It's a brutal process," Fauss tells the audience. "You are getting married to someone for 20-plus years. And it's easier to get a divorce from your husband than it is to get a divorce from your board members."

She explains how keeping that in mind really led her to be picky about her investors and find ones that were right for her and her company.

When it comes to hiring and salary — get it on paper

Every founder will eventually get to a point when they'll need to hire as their company grows. Fauss says she was fortunate to find her early team members organically — through networking opportunities. When it comes to listing jobs online, she recommends being specific to what expertise you're looking for.

In tandem with hiring, founders must decide how they plan to compensate their employees and whether they offer equity — something Goldman says impresses her.

"If a founder convinced other people to join their team based on a promise of getting a part of the company, it means that they are a charismatic entrepreneur and it means that the people who join them believe strongly and passionately about the company," Goldman says.

Belleville adds that founders should be aware of employment agreements, which she doesn't think is necessary in every situation, and confidentiality agreements, which she highly recommends when it comes to protecting the company's intellectual property.

"If you make it part of the [on boarding] process, then everyone has one and you've got that security at the point when they're leaving," Belleville says.

At one point in the panel, Fauss brings up a salary issue she's passionate about.

"Don't forget to budget in your own salary," Fauss says. "Your sweat equity, your worth does have a cost."

She adds that even if you're not getting paid a full salary when you're starting out, it's important to keep in the budget especially when factoring VC money.

Keep your paperwork in order

This might be a no-brainer, but the panelists all echoed the need for properly organized paperwork, especially when it comes to contracts and letters of intent with clients, for general bookkeeping reasons but also for review of potential investors.

"I'm going to want to see that there's actually a binding contract there," Goldman says, adding that the legality and terms of those types of agreements are crucial for her role as an investor.

Belleville says that one way for founders to keep track is by making a detailed spreadsheet with all that's in the contracts — terms, renewal, and termination details, for example.

The panelists — and even some founders in the audience — recommended digital filing systems like Carta, or its free version called captable.io. DocSend was also recommended for sharing your pitch deck because it offers stats so you can see how much time was spent on each page. At the very least, founders should keep files backed up online in Google Docs or DropBox.

When it comes to issuing contacts, Fauss recommends working with a legal team to streamline that process. Ninety percent of contracts will stay the same between clients, she says, so put together a playbook to know which variables to use and when.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.