The hub plans to build on the existing partnership with UH and Baylor, as well as other clinical and research groups within the Texas Medical Center. Photo via Getty Images

The University of Houston and Baylor College of Medicine have been awarded a sizable grant to create a regional research hub.

The National Center for Advancing Translational Research awarded the $44.2 million Clinical and Translational Science Award Program grant to the two schools, which will work to create a regional hub called the Consortium for Translational and Precision Health. CTPH will “serve as a support for infrastructure, services, community engagement and workforce development to advance research and drive innovation in clinical translational science,” per a UH news release.

The hub plans to build on the existing partnership with UH and Baylor, as well as other clinical and research groups within the Texas Medical Center. CTPH aims to connect regional investigators with community healthcare organizations and government agencies that contribute to clinical research, healthcare, and policy. The new hub plans to provide funding for projects in pilot, and support ongoing research to help “accelerate the pace of research from discovery to population level impact,” according to the release. Over 60 leading medical institutions receive CTSA Program funding.

“Research is the engine empowering health care’s life-changing advancements,” UH President Renu Khator says in a news release. “This innovative hub will be a catalyst for groundbreaking discoveries and treatments that improve people’s quality of life. That’s what drives us at UH and we’re ecstatic to cofound a regional hub for change alongside Baylor.”

Leading the program will be Dr. Christopher Amos, professor and director of the Institute for Clinical and Translational Research (ICTR) at BCM; Dr. Fasiha Kanwal, professor of medicine and chief of the section of gastroenterology and hepatology at BCM; and Dr. Bettina M. Beech, clinical professor of population health and the chief population health officer at UH.

The CTPH will also work with Tilman J. Fertitta Family College of Medicine, Andy & Barbara Gessner College of Nursing, College of Pharmacy, College of Optometry, C. T. Bauer College of Business, Cullen College of Engineering, College of Natural Sciences and Mathematics, College of Education, College of Liberal Arts and Social Sciences, and the Honors College — all UH colleges.

“We are deeply committed to advancing innovation in clinical and translational science, and this award is a significant step forward in our mission to improve population health outcomes,” Beech says in a news release. “This is a testament to the unwavering dedication and collaborative spirit of everyone involved. It truly was a team effort.”

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”