Lab safety isn't always standard. Graphic by Miguel Tovar/University of Houston

Safety protocols are only as good as the Principal Investigators who enforce them and the students who adopt them. Operating a lab is no easy feat. It takes patience, consistency and teamwork. In an attempt to learn more about how PIs create a culture of safety, I reached to a few across our university campus to get some tips and tricks for creating effective safety procedures.

A PI’s guide to safety protocols

“My protocol is very clear, and students know the proper attire, but I had one student who arrived at the lab with shorts on. Apparently, he came from the gym … I guess he thought it was OK, but it’s definitely not,” said Mehmet Orman, assistant professor of Chemical and Biomolecular Engineering at the Cullen College of Engineering.

Orman’s research work aims to explore and analyze why some bacterial cells are stubborn to certain therapies. Currently, he uses E. Coli as a model organism to conduct his experiments. His research has the potential to uncover the best methods for combating drug resistant bacteria (aka “super bugs”) which is a seen by many researchers and health organizations as a global crisis.

With such important work, Orman must run a tight ship in his lab. When I spoke to him, he provided his best practices for lab safety.

1. Signage is key

Hazard communication is critical in the lab. “Signage is VERY important. we’ve had students leave Bunsen burners on, which is extremely hazardous. I have signs up everywhere reminding students to turn off the flame.”

2. Remind and repeat

The rule of thumb: you need to hear something 5-7 times for it to sink in. “My lab is new, and my students are young and still learning how to conduct themselves safely. I have to remind them of the protocol religiously, but I’d rather repeat something a million times than have an unfortunate incident occur.”

3. Tailor safety protocols to suit your lab

One size does not fit all when it comes to lab safety. “UH has wonderful, baseline safety protocol and resources for me to use, but every lab is different. I take the foundational information provided by the university and tailor it to fit the needs of my work.”

4. Take baby steps

Throwing students into the experimental deep end can be a big risk when it comes to safety. “Because I am a new researcher at UH and my students are new, I decided to take baby steps with my experiments. My work is about studying drug resistant bacteria, so I decided to begin my scientific exploration with E. coli, a less dangerous organism.” – No pseudomonas aeruginosa just yet.

5. Note to all students: Don’t be shy

“Over time, many of the students become friends. This becomes awkward if they witness their friend violating a safety rule. I encourage the students to speak up (even if it’s their friend), if they see something that threatens everyone’s safety. Everyone wins in the end.”

Safety is a part of the scientific process

Rachel Redfern, O.D., Ph.D., FAAO, is a UH faculty member and an active researcher. Her work focuses on ocular surface inflammation and the impact of contact lenses on normal and diseased eyes. With such sensitive work, safety in the lab is incredibly important to Redfern. She believes keeping her students safe begins at the top but depends on everyone in the lab.

“When students enter my lab, it’s my responsibility to create a safe space where they can perform experiments to answer their growing scientific questions,” said Redfern. “We work as a team to put safety first, but we’re all aware that everyone has different levels of lab safety experience – Every question (regarding safety) is a good one and the questions never asked are the dangerous ones.”

When asked how her students internalize a culture of safety, Redfern praised the education resources of the university.

“At UH, we have access to excellent training to promote a safe culture (shout out to Joe and the UH Environmental Health and Life Safety team!) and training is non-negotiable,” said Redfern. “Also, I often pair new students with seasoned students because setting a good example (among peers) is the best way to encourage students to follow safety practices during routine lab work.”

Eye on safety

When Redfern was a youngster in the lab, she learned that safety was critical to research.

“I was trained by scientists (and worked with peers) who view safety as an element of the scientific process,” said Redfern. “Fortunately, I haven’t been exposed to a ton of outrageous safety violations in my career; however, I have witnessed researchers smoking with latex gloves on and even eating in their dirty lab coats.”

At the end of the day, Redfern just wants to learn more about the complexities of the human eye and Orman wants to study super bugs and how to address a significant health issue. In order to do that, they must conduct experiments with the help of students in a safe environment. This takes team work, group and individual accountability, and everyone’s eye on safety.

When asked about his overall message to PIs and lab safety, Orman simply said, “We’re here for a purpose. We all must have each other’s back to stay safe and conduct meaningful research. It’s just how it is.”

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This article originally appeared on the University of Houston's The Big Idea. Ciandra Jackson, the author of this piece, is the communications manager for the UH Division of Research.

Lab collaboration can help maintain lab safety, these researchers found. Graphic by Miguel Tovar/University of Houston

University of Houston: Teamwork makes the dream work when it comes to lab safety

Houston voices

Getting along with colleagues and forming connections actually helps create a culture of lab safety.

For the most part, we all know how important it is to adhere to universal lab safety rules such as wearing closed-toe shoes or properly labeling all chemicals. Oftentimes, we forget about the human relations side of the safety equation. Cultivating positive working relationships with colleagues is as important (maybe even more so) as learning the “technical” safety rules of a lab. In this edition of the Big Bang, I will discuss the role of interpersonal relationship within the culture of safety.

During my exploration of this topic, I did not specifically find literature that directly links positive interpersonal relationships and lab safety. However, I spoke with a few UH scientists about this topic and I read articles about how to create a positive work environment in the lab in which a common theme arose – communication.

Moreover, the safest labs are operated by people who communicate well and have strong interpersonal relationships. Dr. Colin N. Haile, director of operations at the University of Houston Animal Behavior Core Facility agrees. He runs a complex lab where proper lab safety is vital to the care of the researchers and animals.

“Teamwork and healthy working relationships are extremely important to ensure our work is performed safely and of the best quality,” Dr. Haile said. “When colleagues respect and establish open communication, they are more compelled to help one another adhere to safety protocols.”

Getting along with others is easy, right?

Getting along with others is not easy. We all have diverse backgrounds, life experiences, points of view and expertise. Consequently, the occasional clash with a colleague is not always avoidable.

Frequent showdowns cause disruptions in team morale, productivity and could be a catalyst for an unsafe science lab. In addition to cultivating open communication, there are a few other ways to maintain positive relationships in the lab that contribute to a culture of safety.

Tips for developing and maintaining positive working relationships in your science lab

  • Communication is king & clarity and concision is queen – Communicate exactly what you want and need in a clear, concise manner, especially if there’s a safety issue to address. Also, try to give your email a break – talk to you colleagues face-to-face. This may avoid miscommunication and builds a personal rapport and camaraderie with your teammate.
  • Be nice and respect others – This one is obvious, but important to mention. Stronger bonds and trust is created when you are friendly to colleagues…Hey, you can even take things a step further and show an interest in a co-worker’s family or hobbies outside of the lab. Again, building personal rapport instills trust amongst the group which contributes to safer work environments
  • Keep an open mind and consider diverse points of view – As mentioned earlier, our world is colorful and diverse. That’s what makes humans unique and interesting. Everyone comes from different walks of life and bring unique points of view to their place of business. Preserving superior interpersonal relationships requires colleagues to listen, understand and exhibit compassion towards each other’s points of view. When people are heard, they feel appreciated and possess the motivation to help keep their work space functional and safe.

Strong team = Safer labs and maybe a few cool, new science discoveries

Of course, I’m not suggesting 24-hour Kumbaya in the lab, but the concept of getting along is certainly one that encourages lab safety. Strong teams discover the greatest breakthroughs and are safer in the lab because trust, open communication and respect are established. Well, that’s it for this edition of the Big Bang. Until next time…Be well and stay safe!

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This article originally appeared on the University of Houston's The Big Idea. Ciandra Jackson, the author of this piece, is the communications manager for the UH Division of Research.

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”

Chevron enters the lithium market with major Texas land acquisition

to market

Chevron U.S.A., a subsidiary of Houston-based energy company Chevron, has taken its first big step toward establishing a commercial-scale lithium business.

Chevron acquired leaseholds totaling about 125,000 acres in Northeast Texas and southwest Arkansas from TerraVolta Resources and East Texas Natural Resources. The acreage contains a high amount of lithium, which Chevron plans to extract from brines produced from the subsurface.

Lithium-ion batteries are used in an array of technologies, such as smartwatches, e-bikes, pacemakers, and batteries for electric vehicles, according to Chevron. The International Energy Agency estimates lithium demand could grow more than 400 percent by 2040.

“This acquisition represents a strategic investment to support energy manufacturing and expand U.S.-based critical mineral supplies,” Jeff Gustavson, president of Chevron New Energies, said in a news release. “Establishing domestic and resilient lithium supply chains is essential not only to maintaining U.S. energy leadership but also to meeting the growing demand from customers.”

Rania Yacoub, corporate business development manager at Chevron New Energies, said that amid heightening demand, lithium is “one of the world’s most sought-after natural resources.”

“Chevron is looking to help meet that demand and drive U.S. energy competitiveness by sourcing lithium domestically,” Yacoub said.

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This article originally appeared on EnergyCapital.