Academics have learned quickly that investigations based on data from online research agencies can have problems. Here are those problems and alternatives, according to Rice University researchers. Photo via Getty Images

Academics are learning quickly that investigations based on data from online research agencies have their drawbacks. Thousands of such studies are released every year – and if the data is compromised, so too are the studies themselves.

So it’s natural for researchers, and the managers who rely on their findings, to be concerned about potential problems with the samples they’re studying. Among them: participants who aren’t in the lab and researchers who can’t see who is taking their survey, what they are doing while answering questions or even if they are who they claim to be online. In the wake of a 2018 media piece about Amazon’s Mechanical Turks Service, “Bots on Amazon’s MTurk Are Ruining Psychology Studies,” one psychology professor even mused, “I wonder if this is the end of MTurk research?” (It wasn’t).

To tackle this problem, Rice Business professor Mikki Hebl joined colleagues Carlos Moreno and Christy Nittrouer of Rice University along with several other colleagues to highlight the value of other research methods. Four alternatives – field experiments, archival data, observations and big data – represent smart alternatives to overreliance on online surveys. These methods also have the advantage of challenging academics to venture outside of their laboratories and examine real people and real data in the real world.

Field experiments have been around for decades. But their value is hard to overestimate. Unlike online studies, field experiments enhance the role of context, especially in settings that are largely uncontrolled. It’s hard to fake a field experiment in order to create positive results since each one costs a considerable time and money.

And field experiments can yield real-life results with remarkable implications for society at large. Consider one experiment among 56 middle schools in New Jersey, which found that spreading anti-conflict norms was hugely successful in reducing the need for disciplinary action. Such studies have an impact well beyond what could be achieved with a simple online survey.

The best way to get started with a good field experiment, Hebl and her colleagues wrote, is for researchers to think about natural field settings to which they have access, either personally or by leveraging their networks. Then, researchers should think about starting with the variables critical for any given setting and which they would most like to manipulate to observe the outcome. When choosing variables, it’s helpful to start by thinking about what variable might have conditions leading to the greatest degree of behavior change if introduced into the setting.

Archival data is another excellent way to work around the limitations of online surveys, the researchers argue. These data get around some of the critical drawbacks of field research, including problems around how findings apply in a more general way. Archival data, especially in the form of state or national level data sets, provide information and insight into a large, diverse set of samples that are more representative of the general population than online studies.

Archival data can also help answer questions that are either longitudinal or multilevel in nature, which can be particularly tricky or even impossible to capture with data collected by any single research team. As people spend increasing amounts of time on social media, the internet also serves as a source of newer forms of archival data that can lend unique insights into individuals’ thoughts, attitudes, and behaviors over time.

With every passing year, technology becomes increasingly robust and adept at collecting massive amounts of data on an endless variety of human behavior. For the scientists who research social and personality psychology, the term “big data” refers not only to very large sets of data but also to the tools and techniques that are used to analyze it. The three defining properties of Big Data in this context include the speed of data processing and collection, the vast amount of data being analyzed and the sheer variety of data available.

By using big data, social scientists can generate research based on various conditions, as well as collect data in natural settings. Big data also offers the opportunity to consolidate information from huge and highly diverse stores of data. This technology has many applications, including psychological assessments and improving security in airports and other transportation hubs. In future research, Hebl and her team noted, researchers will likely leverage big data and its applications to detect our unconscious emotions.

Big data, archival information and field studies can all be used in conjunction with each other to maximize the fidelity of research. But researchers shouldn’t forget even more old-fashioned techniques, including the oldest: keen observation. With observation, there are often very few, if any, manipulations and the goal is simply to systematically record the way people behave.

Researchers – and the managers who make decisions based on their findings – should consider the advantages of old-style, often underused methodologies, Hebl and her colleagues argue. Moving beyond the college laboratory and digital data survey-collection platforms and into the real world offers some unparalleled advantages to science. For the managers whose stock prices may hinge on this science, it’s worth knowing – and understanding – how your all-important data was gathered.

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This article originally ran on Rice Business Wisdom and is based on research from Mikki Hebl, the Martha and Henry Malcolm Lovett Professor of psychology at Rice University, and Carlos Moreno and Christy Nittrouer, who are graduate students at Rice University. Additional researchers include Ho Kwan Cheung, Eden B. King, and Hannah Markellis of George Mason University.

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Rice University lands $18M to revolutionize lymphatic disease detection

fresh funding

An arm of the U.S. Department of Health and Human Services has awarded $18 million to scientists at Rice University for research that has the potential to revolutionize how lymphatic diseases are detected and help increase survivability.

The lymphatic system is the network of vessels all over the body that help eliminate waste, absorb fat and maintain fluid balance. Diseases in this system are often difficult to detect early due to the small size of the vessels and the invasiveness of biopsy testing. Though survival rates of lymph disease have skyrocketed in the United States over the last five years, it still claims around 200,000 people in the country annually.

Early detection of complex lymphatic anomalies (CLAs) and lymphedema is essential in increasing successful treatment rates. That’s where Rice University’s SynthX Center, directed by Han Xiao and Lei Li, an assistant professor of electrical and computer engineering, comes in.

Aided by researchers from Texas Children’s Hospital, Baylor College of Medicine, the University of Texas at Dallas and the University of Texas Southwestern Medical Center, the center is pioneering two technologies: the Visual Imaging System for Tracing and Analyzing Lymphatics with Photoacoustics (VISTA-LYMPH) and Digital Plasmonic Nanobubble Detection for Protein (DIAMOND-P).

Simply put, VISTA-LYMPH uses photoacoustic tomography (PAT), a combination of light and sound, to more accurately map the tiny vessels of the lymphatic system. The process is more effective than diagnostic tools that use only light or sound, independent of one another. The research award is through the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics and pHenotyping Technologies (LIGHT) program, part of the U.S. HHS, which saw the potential of VISTA-LYMPH in animal tests that produced finely detailed diagnostic maps.

“Thanks to ARPA-H’s award, we will build the most advanced PAT system to image the body’s lymphatic network with unprecedented resolution and speed, enabling earlier and more accurate diagnosis,” Li said in a news release.

Meanwhile, DIAMOND-P could replace the older, less exact immunoassay. It uses laser-heated vapors of plasmonic nanoparticles to detect viruses without having to separate or amplify, and at room temperature, greatly simplifying the process. This is an important part of greater diagnosis because even with VISTA-LYMPH’s greater imaging accuracy, many lymphatic diseases still do not appear. Detecting biological markers is still necessary.

According to Rice, the efforts will help address lymphatic disorders, including Gorham-Stout disease, kaposiform lymphangiomatosis and generalized lymphatic anomaly. They also could help manage conditions associated with lymphatic dysfunction, including cancer metastasis, cardiovascular disease and neurodegeneration.

“By validating VISTA-LYMPH and DIAMOND-P in both preclinical and clinical settings, the team aims to establish a comprehensive diagnostic pipeline for lymphatic diseases and potentially beyond,” Xiao added in the release.

The ARPA-H award funds the project for up to five years.

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.