Ope Amosu, a Rice University MBA grad, practiced a lot of lean startup techniques when starting his restaurant business, ChòpnBlọk. Photo via Instagram

It was one of those toasty, 95-degree evenings in late September in Houston, and we were clinking our craft cocktails to a full house at ChòpnBlọk's latest pop up concept – the fifth restaurant takeover in his series. I don't know what was hotter… outside, the vibe, or the spice in the ata rodo (scotch bonnet) maple syrup our plantain pancakes were lathered in. But one thing is for sure, as he prepares to open a brick and mortar location in 2020, Ope Amosu, a Rice University MBA graduate and the founder of ChòpnBlọk, is proving himself to be a mean, lean (startup) machine.

After getting his MBA from Rice Business in 2014, he began traveling extensively for work and was frustrated with his inability to easily access authentic West African cuisine in Houston and beyond. He was able to conveniently experience other cultures through successful restaurant concepts, but not his own. So in order to see if he had what it take to bring high quality, convenient West African inspired cuisine to Texas, he did what every MBA graduate dreams of: he rolled up his sleeves and secured a part-time job working the line at Chipotle.

Chipotle taught Ope the art of restaurant operations, and he made money learning it. Pulling together his lessons learned, he began building out his business plan. He identified a large West African population in Houston that was being under-served and was confident in his ability to address this market gap with his fast-casual concept. From his time working with various engineering groups, he knew that he needed to test his idea early so he could fail early and fail fast without breaking the bank.

This led to the inception of ChòpnBlọk. Ope knew acquiring a food truck would be too timely and too expensive, so he went a more creative, cost–effective route. He began hosting private dinners where his guests experienced a multi-course dining program rich with West African flavor.

Those full and happy guests unknowingly were participating in a fun focus group. He leveraged these dinners to collect data from each diner. What did they recommend he charge per meal? Did they like what they were eating? What was their current dining out behaviors? After hosting over ten smaller private dinners, he had collected valuable pieces of information that would inform his business plan including:

  1. He had market data from over 200 diners.
  2. He proved that there was an appetite for West African cuisine in Houston. His fears that the common stigmas about African culture would hinder his growth seemed unfounded.
  3. He quickly optimized operational efficiency in feeding his guests.

Having validated customer demand, honed in on customer preferences, and demonstrated that the market opportunity he believed existed could be captured, all without taking on investors, it was time to take the next step. ChòpnBlọk began efforts to scale, finding a way to re-engage customers who were hungry for more.

This is how the pop-up experiences came to life. With his restaurant takeovers, Ope is able to serve well over 100 paying customers per dinner and gain all the operational know-how that goes along with such an affair. In a risk-free environment, he gets to test various creative concepts and fine-tune logistics…all with almost zero overhead and very minimal risk.

You can probably guess what is next. It should come as no surprise that ChòpnBlọk has been approached by funders and developers to launch a brick and mortar location for 2020. With hundreds of paying customers, a net promoter score staying high at 9/10, and an entrepreneur's tenacity like his, I have a feeling ChòpnBlọk will be coming for Chipotle in just a matter of time.

Want to learn more? Visit their website and follow them on Instagram.

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Caitlin Bolanos is the senior associate director at the Liu Idea Lab for Innovation & Entrepreneurship.

This article originally appeared on Liu Idea Lab for Innovation & Entrepreneurship's blog.

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Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.

New accelerator for AI startups to launch at Houston's Ion this spring

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform.

The AI Native Dual-Use Sports, Health & Wellness Accelerator, scheduled to formally launch in March, will back early-stage startups developing AI for the sports, health and wellness markets. Accelerator participants will gain access to a host of opportunities with:

  • Mentors
  • Advisers
  • Pro sports teams and leagues
  • University athletics programs
  • Health care systems
  • Corporate partners
  • VC firms
  • Pilot projects
  • University-based entrepreneurship and business initiatives

Accelerator participants will focus on sports tech verticals inlcuding performance and health, fan experience and media platforms, data and analytics, and infrastructure.

“Houston is quickly becoming one of the most important innovation hubs at the intersection of sports, health, and AI,” Ashley DeWalt, co-founder and managing partner of The Collectiv and founder of The Collectiv Foundation, said in a news release.

“By launching this platform with Rice University in the Ion District,” he added, “we are building a category-defining acceleration engine that gives founders access to world-class research, global sports properties, hospital systems, and venture capital. This is about turning sports-validated technology into globally scalable companies at a moment when the world’s attention is converging on Houston ahead of the 2026 World Cup.”

The Collectiv accelerator will draw on expertise from organizations such as the Rice-Houston Methodist Center for Human Performance, Rice Brain Institute, Rice Gateway Project and the Texas Medical Center.

“The combination of Rice University’s research leadership, Houston’s unmatched health ecosystem, and The Collectiv’s operator-driven investment platform creates a powerful acceleration engine,” Blair Garrou, co-founder and managing partner of the Mercury Fund VC firm and a senior adviser for The Collectiv, added in the release.

Additional details on programming, partners and application timelines are expected to be announced in the coming weeks.

4 Houston-area schools excel with best online degree programs in U.S.

Top of the Class

Four Houston-area universities have earned well-deserved recognition in U.S. News & World Report's just-released rankings of the Best Online Programs for 2026.

The annual rankings offer insight into the best American universities for students seeking a flexible and affordable way to attain a higher education. In the 2026 edition, U.S. News analyzed nearly 1,850 online programs for bachelor's degrees and seven master's degree disciplines: MBA, business (non-MBA), criminal justice, education, engineering, information technology, and nursing.

Many of these local schools are also high achievers in U.S. News' separate rankings of the best grad schools.

Rice University tied with Texas A&M University in College Station for the No. 3 best online master's in information technology program in the U.S., and its online MBA program ranked No. 21 nationally.

The online master's in nursing program at The University of Texas Medical Branch in Galveston was the highest performing master's nursing degree in Texas, and it ranked No. 19 nationally.

Three different programs at The University of Houston were ranked among the top 100 nationwide:
  • No. 18 – Best online master's in education
  • No. 59 – Best online master's in business (non-MBA)
  • No. 89 – Best online bachelor's program
The University of Houston's Clear Lake campus ranked No. 65 nationally for its online master's in education program.

"Online education continues to be a vital path for professionals, parents, and service members seeking to advance their careers and broaden their knowledge with necessary flexibility," said U.S. News education managing editor LaMont Jones in a press release. "The 2026 Best Online Programs rankings are an essential tool for prospective students, providing rigorous, independent analysis to help them choose a high-quality program that aligns with their personal and professional goals."

A little farther outside Houston, two more universities – Sam Houston State University in Huntsville and Texas A&M University in College Station – stood out for their online degree programs.

Sam Houston State University

  • No. 5 – Best online master's in criminal justice
  • No. 30 – Best online master's in information technology
  • No. 36 – Best online master's in education
  • No. 77 – Best online bachelor's program
  • No. 96 – Best online master's in business (non-MBA)
Texas A&M University
  • No. 3 – Best online master's in information technology (tied with Rice)
  • No. 3 – Best online master's in business (non-MBA)
  • No. 8 – Best online master's in education
  • No. 9 – Best online master's in engineering
  • No. 11 – Best online bachelor's program
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This article originally appeared on CultureMap.com.