8 Houston companies earn spots among Fortune's most innovative for 2025

top honor

Health care companies dominated Fortune's America’s Most Innovative Companies report for 2025, with Houston’s top-rated company on the list falling into that sector. Photo via Getty Images

Eight Houston companies have been named to Fortune’s third annual list of America’s Most Innovative Companies, joining another 16 from the state of Texas.

The group of 300 companies nationwide was rated based on production innovation, process innovation, and innovation culture, according to Fortune. In partnership with Statista, the magazine considered IP portfolios, employee, expert and customer opinions; and many other factors.

While many of the top-rated companies fell into the tech sector, Fortune reports that health care companies made up the largest portion of the 2025 list. Sixty-three honorees fell into the health care category, including Houston’s top-rated company, Houston Methodist.

Here’s which Houston companies made the list and where they ranked:

  • No. 35 — Houston Methodist
  • No. 54. — ExxonMobil
  • No. 137 — NRG Energy
  • No. 158 — Hewlett-Packard Enterprise
  • No. 169 — BMC Software
  • No. 175 — Texas Children’s Hospital
  • No. 227 — Sysco
  • No. 268 — Chevron

“This award is a true credit to the culture we have created around innovation and the incredible work of Roberta Schwartz, our Chief Innovation Officer, and her team at the Center for Innovation,” Marc Boom, CEO of Houston Methodist, said in a LinkedIn post. “They have really set the tone for how we can use innovation and technology to continue to deliver the highest quality care for our patients.”

Dallas-Fort Worth claimed the largest number of Texas companies on the list, with 11 headquartered in the metroplex. Houston was home to the second-most with eight hailing from the Bayou City. Austin is home to only four of the companies on the list, however, companies from the Capital City ranked higher on average, with Oracle, Tesla and Dell Technologies claiming the top three spots for the state. Beloved Texas grocer H-E-B was the one company to represent San Antonio.

Here's how the other Texas companies fared:

  • No. 6 — Oracle
  • No. 11 — Tesla
  • No. 14 — Dell Technologies
  • No. 37 — AT&T
  • No. 59 — Texas Instruments
  • No. 89 — Charles Schwab
  • No. 91 — McKesson
  • No. 113 — Jacobs Solutions
  • No. 125 — Baylor, Scott & White Health
  • No. 165 — Frontier Communications
  • No. 201— H-E-B
  • No. 210 — CBRE Group
  • No. 219 — TTEC Holdings
  • No. 223 — GameStop
  • No. 251 — American Airlines Group
  • No. 271 — Caterpillar

California-based tech conglomerate Alphabet Inc. topped the list for the third year in a row, and California companies again represented the majority of companies on the list, according to Fortune. Alphabet, Microsoft, Apple, IBM and Salesforce made up the top five, of which three are headquartered in California.

The 2025 group had a median revenue of $22 billion over the last 12 months, according to Fortune. See the full report here.

From Your Site Articles
Ten Rice University energy innovators have been selected for the Chevron Energy Graduate Fellowship. Photo by of Jeff Fitlow/Rice University

Chevron names inaugural cohort of Houston energy innovators

research ready

Anew program from Rice University and Chevron has named its inaugural cohort.

Funded by Chevron, the Chevron Energy Graduate Fellowship will provide $10,000 each to 10 Rice graduate students for the current academic year, which supports research in energy-related fields.

The Rice Sustainability Institute (RSI) hosted the event to introduce the inaugural cohort of the Rice Chevron Energy Graduate Fellowship at the Ralph S. O’Connor Building for Engineering and Science. Director of the RSI and the W. Maurice Ewing Professor in Earth, Environmental and Planetary Sciences, Carrie Masiello presented each fellow with a certificate during the ceremony.

“This fellowship supports students working on a wide range of topics related to scalable innovations in energy production that will lead to the reduction of carbon dioxide emissions,” Masiello says in a news release. “It’s important that we recognize the importance of intellectual diversity to the kind of problem-solving we have to do as we accomplish the energy transition.”

The work of the students focuses on creating "real-world, scalable solutions to transform the energy landscape,” per the Rice release. Recipients of the fellowship will research solutions to energy challenges that include producing eco-friendly hydrogen alternatives to fossil fuels and recycling lithium-ion batteries.

Some of the fellows' work will focus on renewable fuels and carbon-capture technologies, biological systems to sequester carbon dioxide, and the potential of soil organic carbon sequestration on agricultural land if we remove the additionality constraint. Xi Chen, a doctoral student in materials science and nanoengineering, will use microwave-assisted techniques to recycle lithium-ion batteries sustainably.

Rice President Reginald DesRoches began the event by stressing the importance of collaboration. Ramamoorthy Ramesh, executive vice president for research at Rice, echoed that statement appearing via Zoom to applaud the efforts of doing what is right for the planet and having a partner in Chevron.

“I’m excited to support emerging leaders like you all in this room, who are focused on scalable, innovative solutions because the world needs them,” Chris Powers, vice president of carbon capture, utilization and storage and emerging at Chevron New Energies and a Rice alum, says at the event. “Innovation and collaboration across sectors and borders will be key to unlocking the full potential of lower carbon energies, and it’s groups like you, our newest Chevron Fellows, that can help move the needle when it comes to translating, or evolving, the energy landscape for the future.”

To see a full list of fellows, click here.

------

This article originally ran on EnergyCapital.

Houston-based energy companies have again held a sizable presence on the Fortune 500 ranking. Photo via Getty Images

Houston companies score big on annual Fortune 500 ranking

by the numbers

Fourteen businesses with global or regional headquarters in the Houston area appear on Fortune’s new list of the world’s 500 biggest companies.

Oil and gas company Saudi Aramco, whose headquarters for the Americas is in Houston, leads the Houston-area pack. With annual revenue of $494.9 billion, it lands at No. 4 on the Fortune Global 500. Ahead of Saudi Aramco are U.S. retailers Walmart and Amazon, and Chinese electric company State Grid.

To put Saudi Aramco’s annual revenue in perspective, the total is slightly above the gross domestic product for the Philippines.

For the third year in a row, Saudi Aramco stands out as the most profitable member of the Fortune Global 500. The company racked up $121 billion in profit last year.

Overall, Saudi Aramco and 32 other petroleum refiners — many of them with a significant presence in the Houston area — made the Fortune Global 500.

“The Global 500 is the ultimate scorecard for business success. The aggregate revenue of the Fortune Global 500 in 2023 reached $41 trillion, a record level. That sum represents more than a third of global GDP — a sign of how much economic power is concentrated in these companies,” Scott DeCarlo, Fortune’s vice president of research, says in a news release.

Here’s the rundown of Fortune Global 500 companies with global or regional headquarters in the Houston area, including the ranking and annual revenue for each:

  • Saudi Aramco, No. 4, $494.9 billion, Americas headquarters in Houston
  • ExxonMobil, No. 12, $344.6 billion, global headquarters in Spring
  • Shell, No. 13, $323.2 billion; U.S. headquarters in Houston
  • TotalEnergies, No. 23, $218.9 billion, U.S. headquarters in Houston
  • BP, No. 25, $213 billion, U.S. headquarters in Houston
  • Chevron, No. 29, $200.9 billion, global headquarters relocating to Houston in 2024
  • Phillips 66, No. 52, $149.9 billion, global headquarters in Houston
  • Engie, No. 130, $89.3 billion, North American headquarters in Houston
  • Sysco, No. 163, $76.3 billion, global headquarters in Houston
  • ConocoPhillips, No. 235, $58.6 billion, global headquarters in Houston
  • Enterprise Products Partners, No. 303, $49.7 billion, global headquarters in Houston
  • Plains GP Holdings, No. 311, $48.7 billion, global headquarters in Houston
  • LyondellBasell, No. 368, $41.1 billion, global headquarters in Houston
  • SLB (formerly Schlumberger), No. 479, $33.1 billion, global headquarters in Houston

Fortune uses revenue figures for budget years ending on or before March 31, 2024, to rank the world’s largest companies.

------

This article originally ran on EnergyCapital.

The HyVelocity Hub, representing the Gulf Coast region, will receive $1.2 billion to strengthen and further build out the region's hydrogen production. Photo via Getty Images

Houston-area selected among 7 regions for $7B federal hydrogen hub investment

hi, hydrogen

A Houston-area project got the green light as one of the seven regions to receive a part of the $7 billion in Bipartisan Infrastructure Law funding to advance domestic hydrogen production.

President Joe Biden and Energy Secretary Jennifer Granholm named the seven regions to receive funding in a White House statement today. The Gulf Coast's project, HyVelocity Hydrogen Hub, will receive up to $1.2 billion — the most any hub will receive, per the release.

“As I’ve stated repeatedly over the past years, we are uniquely positioned to lead a transformational clean hydrogen hub that will deliver economic growth and good jobs, including in historically underserved communities," Houston Mayor Sylvester Turner says in a news release. "HyVelocity will also help scale up national and world clean hydrogen economies, resulting in significant decarbonization gains. I’d also like to thank all the partners who came together to create HyVelocity Hub in a true spirit of public-private collaboration.”

Backed by industry partners AES Corporation, Air Liquide, Chevron, ExxonMobil, Mitsubishi Power Americas, Ørsted, and Sempra Infrastructure, the HyVelocity Hydrogen Hub will connect more than 1,000 miles of hydrogen pipelines, 48 hydrogen production facilities, and dozens of hydrogen end-use applications across Texas and Southwest Louisiana. The hub is planning for large-scale hydrogen production through both natural gas with carbon capture and renewables-powered electrolysis.

The project is spearheaded by GTI Energy and other organizing participants, including the University of Texas at Austin, The Center for Houston’s Future, Houston Advanced Research Center, and around 90 other supporting partners from academia, industry, government, and beyond.

“Prioritizing strong community engagement and demonstrating an innovation ecosystem, the HyVelocity Hub will improve local air quality and create equitable access to clean, reliable, affordable energy for communities across the Gulf Coast region,” says Paula A. Gant, president and CEO of GTI Energy, in a news release.

According to the White House's announcement, the hub will create 45,000 direct jobs — 35,000 in construction jobs and 10,000 permanent jobs. The other selected hubs — and the impact they are expected to have, include:

  • Tied with HyVelocity in terms of funding amount, the California Hydrogen Hub — Alliance for Renewable Clean Hydrogen Energy Systems (ARCHES) — will also receive up to $1.2 billion to create 220,000 direct jobs—130,000 in construction jobs and 90,000 permanent jobs. The project is expected to target decarbonizing public transportation, heavy duty trucking, and port operations.
  • The Midwest Alliance for Clean Hydrogen (MachH2), spanning Illinois, Indiana, and Michigan, will receive up to $1 billion. This region's efforts will be directed at optimizing hydrogen use in steel and glass production, power generation, refining, heavy-duty transportation, and sustainable aviation fuel. It's expected to create 13,600 direct jobs—12,100 in construction jobs and 1,500 permanent jobs.
  • Receiving up to $1 billion and targeting Washington, Oregon, and Montana, the Pacific Northwest Hydrogen Hub — named PNW H2— will produce clean hydrogen from renewable sources and will create over 10,000 direct jobs—8,050 in construction jobs and 350 permanent jobs.
  • The Appalachian Regional Clean Hydrogen Hub (ARCH2), which will be located in West Virginia, Ohio, and Pennsylvania, will tap into existing infrastructure to use low-cost natural gas to produce low-cost clean hydrogen and permanently and safely store the associated carbon emissions. The project, which will receive up to $925 million, will create 21,000 direct jobs—including more than 18,000 in construction and more than 3,000 permanent jobs.
  • Spanning Minnesota, North Dakota, and South Dakota, the Heartland Hydrogen Hub will receive up to $925 million and create around 3,880 direct jobs–3,067 in construction jobs and 703 permanent jobs — to decarbonize the agricultural sector’s production of fertilizer, decrease the regional cost of clean hydrogen, and advance hydrogen use in electric generation and for cold climate space heating.
  • Lastly, the Mid-Atlantic Clean Hydrogen Hub (MACH2), which will include Pennsylvania, Delaware, and New Jersey, hopes to repurposing historic oil infrastructure to develop renewable hydrogen production facilities from renewable and nuclear electricity. The hub, which will receive up to $750 million, anticipates creating 20,800 direct jobs—14,400 in construction jobs and 6,400 permanent jobs.

These seven clean hydrogen hubs are expected to catalyze more than $40 billion in private investment, per the White house, and bring the total public and private investment in hydrogen hubs to nearly $50 billion. Collectively, they aim to produce more than three million metric tons of clean hydrogen annually — which reaches nearly one third of the 2030 U.S. clean hydrogen production goal. Additionally, the hubs will eliminate 25 million metric tons of carbon dioxide emissions from end uses each year. That's roughly equivalent to annual emissions of over 5.5 million gasoline-powered cars.

“Unlocking the full potential of hydrogen—a versatile fuel that can be made from almost any energy resource in virtually every part of the country—is crucial to achieving President Biden’s goal of American industry powered by American clean energy, ensuring less volatility and more affordable clean energy options for American families and businesses,” U.S. Secretary of Energy Jennifer M. Granholm says in the release. “With this historic investment, the Biden-Harris Administration is laying the foundation for a new, American-led industry that will propel the global clean energy transition while creating high quality jobs and delivering healthier communities in every pocket of the nation.”

HyVelocity has been a vision amongst Houston energy leaders for over a year, announcing its bid for regional hydrogen hub funding last November. Another Houston-based clean energy project was recently named a semi-finalist for National Science Foundation funding.

“We are excited to get to work making HyVelocity come to life,” Brett Perlman, president and CEO of Center for Houston’s Future, says in the release. “We look forward to spurring economic growth and development, creating jobs, and reducing emissions in ways that will benefit local communities and the Gulf Coast region as a whole. HyVelocity will be a model for creating a clean hydrogen ecosystem in an inclusive and equitable manner.”

------

This article originally ran on EnergyCapital.

DivInc's newest accelerator based in Houston will support Web3 companies with a social impact. Photos courtesy of DivInc

Texas organization announces inaugural cohort of social enterprise startups with Web3 tech

Dedicated to DWeb

A Texas-based accelerator focused on helping BIPOC and female founders on their entrepreneurial journeys announced the inaugural class for its newest accelerator.

DivInc's DWeb for Social Impact Accelerator, a 12-week intensive hybrid program sponsored by Filecoin Foundation for the Decentralized Web, will mentor nine companies, all of whom integrate Web3 technologies into their impact entrepreneurship. Participating startups will have access to the Ion’s resources and receive a non-dilutive $10,000 grant to use during the course of the program.

Cherise Luter, marketing director at DivInc, says the Austin-based development program instead chose Houston to host this inaugural cohort because they have a secure partnership with the Ion and other premiere partners in the area, including Mercury, JP Morgan, and Bank of America.

“The team that we already have in place in Houston is so strong, we thought, this would be a great place to launch this concept and then from there determine if we want to launch it in Austin,” Luter says.

Amanda Moya, director of programs for DivInc, says this accelerator will truly be hybrid, enabling entrepreneurs from around the country to benefit from quality virtual mentorship and four weeks of in-person training.

“We want to really engulf them in the Houston innovation ecosystem, to let them know that this is also a landing pad if they are ever to move or travel around and come back to Houston,” Moya mentions.

One Houston-based startup, CultureLancer, will be participating in the program. A career-focused platform that matches students from HBCU with companies looking to hire in the fields of business development, data analysis, marketing, and operations, CultureLancer provides students with project-based learning opportunities.

Brianna Brazle, CultureLancer founder and therapist, says after discussing with friends and family members their struggles to get hired post-graduation she uncovered an underserved market of people in need of career guidance.

“That’s a problem that has been existing and then after doing more research I learned historically about 56%, year over year, of college graduates find themselves unemployed or underemployed,” Brazle explains. “My first solution to this problem was a hybrid marketplace.”

The rest of the inaugural cohort includes one to two entrepreneurs from the following companies:

  • Craftmerce, based in Dallas, is a B2B technology platform that brings African artisans and mainstream retail partners together through distributed production, enterprise management, and financing tools.
  • Instarails is working to simplify cross border payments through their API which provides the option to make instant global payments regardless of currency.
  • Looks for Lease, a Los Angeles based wardrobe rental company is combating the carbon emissions brought on by the fashion industry through their circular consumerism business model which operates on an AR platform.
  • Motherocity is an app that allows postpartum moms to track their mental and physical health through personal insights, experiential data, data science, and artificial intelligence, all the way through the first year after giving birth.
  • Salubata combines sustainable fashion and tech through their shoes made from old plastic bottles and integrating an NFT component that allows access to new shoe designs for customers.
  • Seed At The Table is a crowdfunding platform connecting marginalized founders with non-accredited investors, founded by a former Goldman Sachs investment manager.
  • Tribe is a mental health mobile app aiming to make mental healthcare affordable and accessible to black people through their directory of black therapists whose patients can directly book appointments within the app.
  • Subler, which was founded by a Los Angeles high school board member, is a digital marketplace that allows schools to rent out their unused spaces to local community groups.

The program will run from Sept. 18 until their demonstration day which is scheduled for Dec. 7 at the Ion.

DivInc, which runs several accelerators across Texas, originally partnered with the Ion in 2020. The organization introduced its new DWeb program earlier this year.

Last month, DivInc also introduced its inaugural cohort to another new diversity-focused accelerator. The 2023 Clean Energy Tech accelerator program sponsored by Chevron and Microsoft is currently ongoing.

The University of Houston has teamed up with Chevron for a new fellowship program, which just announced its first class. Photo courtesy of UH.edu

University of Houston reveals inaugural cohort of energy research fellows

powered by chevron

The University of Houston has named eight graduate students to its first-ever cohort of UH-Chevron Energy Graduate Fellows.

The PhD and doctoral students will each receive a one-year $12,000 fellowship, along with mentoring from experts at UH and Chevron.

“The UH-Chevron Energy Fellowship program is an exciting opportunity for our graduate students to research the many critical areas that impact the energy industry, our communities and our global competitiveness,” Ramanan Krishnamoorti UH's Vice President for Energy and Innovation says in a statement.

“Today’s students not only recognize the importance of energy, but they are actively driving the push for affordable, reliable, sustainable and secure energy and making choices that clearly indicate that they are meaningfully contributing to the change,” he continues.

Their work focuses on energy-related research in fields ranging from public policy to geophysics and math. The fellowship is funded by Chevron.

“We love that Chevron is sponsoring this group of fellows because it’s a fantastic way for us to get involved with the students who are working on some of the biggest problems we’ll face in society,” Chevron Technology Ventures President Jim Gable adds.

The 2023 UH-Chevron Energy Graduate Fellows are:

The PhD and doctoral students will each receive a one-year $12,000 fellowship, along with mentoring from experts at UH and Chevron. Photo via UH.edu

Kripa Adhikari, a Ph.D. student in the Department of Civil and Environmental Engineering in the Cullen College of Engineering. Her work focuses on thermal regulation in enhanced geothermal systems. She currently works under the mentorship of Professor Kalyana Babu Nakshatrala and previously worked as a civil engineer with the Nepal Reconstruction Authority.

Aparajita Datta, a researcher at UH Energy and a Ph.D. candidate in the Department of Political Science. Her work focuses on the federal Low-Income Home Energy Assistance Program (LIHEAP), a redistributive welfare policy designed to help households pay their energy bills. She holds a bachelor’s degree in computer science and engineering from the University of Petroleum and Energy Studies in India, and master’s degrees in energy management and public policy from UH. She also recently worked on a paper for UH about transportation emissions.

Chirag Goel, a Ph.D. student in materials science and engineering at UH. His work focuses on using High Temperature Superconductors (HTS) to optimize manufacturing processes, which he says can help achieve carbon-free economies by 2050. The work has uses in renewable energy generation, electric power transmission and advanced scientific applications.

Meghana Idamakanti, a third-year Ph.D. student in the William A. Brookshire Department of Chemical and Biomolecular Engineering. Her work focuses on using electrically heated steam methane for cleaner hydrogen production. She received her bachelor’s degree in chemical engineering from Jawaharlal Nehru Technological University in India in 2020 and previously worked as a process engineering intern at Glochem Industries in India.

Erin Picton, an environmental engineering Ph.D. student in the Shaffer Lab at UH. Her work focuses on ways to increase the sustainability of lithium processing and reducing wasted water and energy. “I love the idea of taking waste and turning it into value,” she said in a statement. She has previously worked in collaboration with MIT and Greentown Labs, as chief sustainability officer of a Houston-based desalination startup; and as a visiting graduate researcher at Argonne National Lab and at INSA in Lyon, France.

Mohamad Sarhan, a Ph.D. student and a teaching assistant in the Department of Petroleum Engineering. His work focuses on seasonal hydrogen storage and the stability of storage candidates during hydrogen cycling. He holds a bachelor’s degree and a master’s degree in petroleum engineering from Cairo University

Swapnil Sharma, a Ph.D. student in the William A. Brookshire Department of Chemical and Biomolecular Engineering. His work has been funded by the Department of Energy and focuses on thermal modeling of large-scale liquid hydrogen storage tanks. He works with Professor Vemuri Balakotaiah. He holds bachelor's and master’s degrees in chemical engineering from the Indian Institute of Technology (IIT). He also developed one of the world’s highest fiber-count optical fiber cables while working in India and founded CovRelief, which helped millions of Indians find resources about hospital beds, oxygen suppliers and more during the pandemic.

Larkin Spires, who's working on her doctoral research in the Department of Earth and Atmospheric Sciences in the College of Natural Sciences and Mathematics. Her work focuses on a semi-empirical Brown and Korringa model for fluid substitution and the ties between geophysics and mathematics. She works under Professor John Castagna and holds a bachelor’s degree in math from Louisiana State University and a master’s degree in geophysics from UH.

Earlier this month Evolve Houston also announced its first-ever cohort of 13 microgrant recipients, whose work aims to make EVs and charging infrastructure more accessible in some of the city's more underserved neighborhoods.

------

This article originally ran on EnergyCapital.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

Elon Musk's SpaceX site officially becomes the city of Starbase, Texas

Starbase, Texas

The South Texas home of Elon Musk’s SpaceX rocket company is now an official city with a galactic name: Starbase.

A vote Saturday, May 3, to formally organize Starbase as a city was approved by a lopsided margin among the small group of voters who live there and are mostly Musk’s employees at SpaceX. With all the votes in, the tally was 212 in favor to 6 against, according to results published online by the Cameron County Elections Department.

Musk celebrated in a post on his social platform, X, saying it is “now a real city!”

Starbase is the facility and launch site for the SpaceX rocket program that is under contract with the Department of Defense and NASA that hopes to send astronauts back to the moon and someday to Mars.

Musk first floated the idea of Starbase in 2021 and approval of the new city was all but certain. Of the 283 eligible voters in the area, most are believed to be Starbase workers.

The election victory was personal for Musk. The billionaire’s popularity has diminished since he became the chain-saw-wielding public face of President Donald Trump’s federal job and spending cuts, and profits at his Tesla car company have plummeted.

SpaceX has generally drawn widespread support from local officials for its jobs and investment in the area.

But the creation of an official company town has also drawn critics who worry it will expand Musk’s personal control over the area, with potential authority to close a popular beach and state park for launches.

Companion efforts to the city vote include bills in the state Legislature to shift that authority from the county to the new town’s mayor and city council.

All these measures come as SpaceX is asking federal authorities for permission to increase the number of South Texas launches from five to 25 a year.

The city at the southern tip of Texas near the Mexico border is only about 1.5 square miles (3.9 square kilometers), crisscrossed by a few roads and dappled with airstream trailers and modest midcentury homes.

SpaceX officials have said little about exactly why they want a company town and did not respond to emailed requests for comment.

“We need the ability to grow Starbase as a community,” Starbase General Manager Kathryn Lueders wrote to local officials in 2024 with the request to get the city issue on the ballot.

The letter said the company already manages roads and utilities, as well as “the provisions of schooling and medical care” for those living on the property.

SpaceX officials have told lawmakers that granting the city authority to close the beach would streamline launch operations. SpaceX rocket launches and engine tests, and even just moving certain equipment around the launch base, requires the closure of a local highway and access to Boca Chica State Park and Boca Chica Beach.

Critics say beach closure authority should stay with the county government, which represents a broader population that uses the beach and park. Cameron County Judge Eddie Trevino, Jr. has said the county has worked well with SpaceX and there is no need for change.

Another proposed bill would make it a Class B misdemeanor with up to 180 days in jail if someone doesn’t comply with an order to evacuate the beach.

The South Texas Environmental Justice Network, which has organized protests against the city vote and the beach access issue, held another demonstration Saturday that attracted dozens of people.

Josette Hinojosa, whose young daughter was building a sandcastle nearby, said she was taking part to try to ensure continued access to a beach her family has enjoyed for generations.

With SpaceX, Hinojosa said, “Some days it’s closed, and some days you get turned away."

Organizer Christopher Basaldú, a member of the Carrizo/Comecrudo Nation of Texas tribe, said his ancestors have long been in the area, where the Rio Grande meets the Gulf.

“It’s not just important,” he said, “it’s sacred.”

View All Listings
X

INNOVATIONMAP EMAILS ARE AWESOME