3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Tim Crain of Intuitive Machines, Chelsea Williams of Northwestern Mutual, and Nicolaus Radford of Nauticus Robotics. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from space tech to robotics — recently making headlines in Houston innovation.

Tim Crain, co-founder and CTO of Intuitive Machines

Tim Crain joins the Houston Innovators Podcast. Photo via intuitivemachines.com

It might surprise many to learn that publicly traded, NASA-backed Intuitive Machines, which has emerged as a commercial leader within lunar access technology development, had several pivots before finding its niche within space innovation.

In fact, as Co-Founder and CTO Tim Crain explains on this week's episode of the Houston Innovators Podcast, the company was founded as a space-focused think tank. Crain, along with his co-founders CEO Steve Altemus and Chairman Kamal Ghaffarian, came together in 2013 to start Intuitive Machines, which recently moved into a $40 million headquarters in the Houston Spaceport.

"At the time, our thought was, 'let's take the best of human space flight engineering processes, disciplines, and know how, and look at how we might commercially deploy that for biomedical, energy, big data, and aerospace,'" Crain says on the show. "We wanted to look at how we use great engineering for some of the hard problems outside of NASA's aerospace sphere." Read more.

Chelsea Williams, financial adviser at Northwestern Mutual

Houston-based financial adviser Chelsea Williams helps clients overcome their unique generational financial uncertainties by equipping them with tips and resources to get them on the path to financial wellness. Photo courtesy

In a guest column for InnovationMap, Chelsea Williams, financial adviser at Northwestern Mutual, shared tips on overcoming financial uncertainty across different generations.

"While the types of financial stressors might vary across generations and cities, the most important step to managing financial uncertainty is initiating a conversation with an adviser," she writes in her column. "Just like going to the doctor regularly, routine financial check-ups are incredibly important to catch financial headaches early on and stay ahead of long-term financial health." Read more.

Nicolaus Radford, founder and CEO of Nauticus Robotics

Houston-based Nauticus Robotics founder, Nicolaus Radford, celebrated an acquisition for his company. Image via LinkedIn

A Houston company that harnesses the power of robotics hardware and programing for underwater use has made an acquisition.

Nauticus Robotics Inc. (NASDAQ: KITT) announced it has acquired 3D at Depth Inc., a Colorado-based company with a subsea light detection and range, LiDAR, technology for inspection and data services. The deal closed for approximately $34 million in stock, before certain purchase price adjustments and the assumption of debt, per the news release.

“The future of subsea services lies in autonomy, data gathering, and analytics,” Nicolaus Radford, Nauticus’ founder and CEO, says in the release. “LiDAR has long since been core to terrestrial autonomy and by adding 3D’s capabilities to the Nauticus Fleet, we enhance autonomous vehicles in the offshore market. This acquisition increases the value of Nauticus’ fleet services and positions the Company to capitalize on data acquisition and analytics for subsea operations.” Read more.

Houstonians in particular expressed more stress than other communities in terms of household finances and physical and mental health. Photo via Getty Images

Houston expert on tips on overcoming financial uncertainty across different generations

guest column

Whether you’re a millennial or baby boomer, financial uncertainty is not limited by age, with new data from Northwestern Mutual’s 2023 Planning & Progress Study revealing that most Americans are losing sleep at night because of it. Houstonians in particular expressed more stress than other communities in terms of household finances and physical and mental health, according to a recent survey.

While the types of financial stressors might vary across generations and cities, the most important step to managing financial uncertainty is initiating a conversation with an adviser. Just like going to the doctor regularly, routine financial check-ups are incredibly important to catch financial headaches early on and stay ahead of long-term financial health.

As a Houston-based financial adviser, I help my clients overcome their unique generational financial uncertainties by equipping them with tips and resources to get them on the path to financial wellness.

Understanding where financial uncertainty comes from generationally

  • Gen Z: Studies have shown that even while Gen Z is the most confident that they’ll be prepared for retirement when the time comes, they still struggle with feelings of uncertainty on how to achieve their specific financial goals. In my experience, I have found that uncertainty among this age group often stems from a lack of financial literacy surrounding their finances. A recent financial literacy study revealed that Gen Z respondents averaged the lowest at 43 percent in answering finance-related questions correctly.
  • Millennials: Millennials equally suffer from feelings of anxiety about money, with 54 percent of millennial respondents in the P&P study indicating that financial anxiety causes them to feel depressed compared to just 20 percent of baby boomers. Millennials have lived through a pandemic, The Great Recession and slow economic growth, making their mental health and financial wellness a top priority.
  • Gen X: Even while financial uncertainty typically starts to recede later in life at this age, Gen X is facing a turning point as they get closer and closer to retirement. Studies have shown that most Americans believe they will need about $1.27 million to retire comfortably and yet, I see many individuals only recognizing the importance of retirement planning between the ages of 40 and 50. With Gen X holding about six times more debt than their parents did at that age, it’s important for this age group to consider some proactive debt and retirement strategies.
  • Baby boomers: This group has the lowest amount of financial uncertainty, but that doesn’t mean it is nonexistent. I hear a lot of baby boomers state that they wish they had started investing sooner or they wish they had conversations about their finances sooner. As such, this group is typically the most concerned about managing their existing assets and living comfortably for the rest of their lives.

Overcoming financial uncertainty

  • Increase financial literacy: Both millennials and Gen Z grew up in the digital age and expect their financial experiences to be reflective of that. For employers with Gen Z employees, working with a Northwestern Mutual financial adviser on resources to increase financial literacy can be a helpful first step. This could include on-demand webinars, digital toolkits and interactive online portals to access and view their finances.
  • Ensure every dollar has a job: Across all generations, it’s important to ensure no dollar is wasted. In other words, understanding how much of your income should be allocated toward expenses, retirement, savings, etc. is crucial. I typically recommend a budgeting rule that no more than half of an individual’s income goes toward expenses.
  • Initiate financial planning discussions early on: While it may seem daunting, results from the P&P study show that an average of 76 percent of individuals who work with a financial adviser have an overall boost to confidence. With Gen Z often heavily relying on family members for money management, it is important that family members from older generations encourage them to start saving or to consult with a financial adviser at a young age.
  • Take proactive steps toward your finances: No matter what age you are, there are always active steps you can be taking with your finances. Consider increasing the contribution amount to your 401(k) savings plan or working with a financial adviser to diversify your existing investments – or talk to your financial adviser about refinancing opportunities or debt strategies that tackle higher interest loans you may have.
     

Whether you’re in your 20s or your 50s, financial advisers are uniquely prepared to help you at any stage of your life – and overcome whatever uncertainties you may be facing.


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Chelsea Williams is a financial adviser at Northwestern Mutual. She's based in Houston and has clients across the country.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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