A Houston-area company has created an easy-to-use health-check app for employees returning to work. Pexels

A Woodlands-based health services company recently announced a new app that can serve as a self-service pre-screening tool for COVID-19 to be used by employees to return to their workplace.

Axiom Medical created the CheckIn2Work app to make the transition into the workplace after the coronavirus crisis safer and easier, making it simple for businesses and offices to reopen after stay-at-home orders shut down workplaces during the height of the pandemic.

"Given the current challenges we have all experienced with COVID-19, we recognize the workplace will be forever changed," says Axiom Medical President and CEO Mark Robinson. "Our CheckIn2Work app simply adds another layer to protecting the health of team members, customers, and vendors from the risk of infectious disease in the workplace."

The app includes features such as a 24/7 self-service illness screening with the latest screening criteria approved by Chief Medical Officer Scott Cherry. The app also includes immediate access to U.S.-based Clearance Center for exposure/illness alerts, real-time reporting, and ongoing best practices to reduce the spread of the virus in the work environment.

When an app user is flagged as exposed to the virus, Axiom Medical's Rapid Response Contagious Respiratory Illness Assessment Clearance Center professionals can conduct secondary screening procedures via a phone call to confirm cases and eliminate false positives.

The app has 50,000 users already from Axiom's new and existing clients who have signed on to the platform. Some of their partners include BJ Services, Tyson Foods, ISS Facility Services, and Fort Bend Kia, Robinson says it creates safe and healthy facilities for both employees and customers.

"It enables our clients to be appropriately responsive to trying to screen out the infection in their workplace," says Robinson, "It also gives employees confidence that returning to work and exposing themselves to their coworkers is safe while providing customers who have contact with the employees with the confidence who they will be interacting with has been screened and cleared."

For the health services company, keeping employees safe has been the heart of their mission since it was founded more than two decades ago. Axiom Medical markets itself as an employer's outsourced "in house" medical department, managing a complete array of occupational health services such as scheduling exams, verifying results for accuracy, and maintaining records.

"Our focus is on the health of the worker in the workplace," says Robinson. "Both our traditional services and our new service all focus on keeping people as healthy as possible, returning them to work as quickly as possible after an injury or illness keeps them out of the workplace, and making sure they are tested for a variety of risks."

CheckIn2Work is now available on iOS and Android mobile devices including a web portal where employees can check in before work every day to check for symptoms of COVID-19. The app is adaptable with language settings in English and Spanish and allows for customizable questions to fit an organization's needs.

"I hope we can continue to take this seriously and take good precautions," says Robinson. "This is a really horrible disease, it isn't just about the people who die as a result, it's also about those who are permanently disabled because of it. Those weeks in a hospital are mirrored by more weeks in recovery before they can even think about working again."

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”