These are Houston's 4 best high schools in 2021, says recent report

REPORT CARD

Here's what Houston schools have been lauded for training the city's future leaders. Photo by skynesher/Getty Images

t's report card time, and four Houston high schools have made the grade, earning top 100 spots in this year's prestigious U.S. News & World Report rankings of the Best U.S. High Schools. One even merited a special distinction.

Houston's Carnegie Vanguard High School ranked highest on the list at No. 42. The school is ranked fifth within Texas. The Advanced Placement coursework participation rate there is 100 percent; total minority enrollment is 77 percent, and 31 percent of students are economically disadvantaged.

Following close behind is the prestigious DeBakey High School for Health Professions at No. 46 overall. The renowned medical prep school boasts an AP participation rate of 98 percent, total minority enrollment is 88 percent, and 44 percent of students are economically disadvantaged.

Farther down the list is Challenge Early College High School, at No. 89 overall. The AP participation rate here is 100 percent, total minority enrollment is 92 percent, and 76 percent of students are economically disadvantaged.

At No. 97 overall is Young Women's College Prep Academy. The AP participation rate here is 100 percent. The total minority enrollment is 97 percent, and nearly all students — some 96 percent — are economically disadvantaged.

The 2021 edition is U.S. News' most comprehensive survey yet, with the consumer advice outlet evaluating more than 17,800 public high schools on how well they serve all of their students, regardless of economic or ethnic background.

To determine rankings, they focus on six factors: college readiness, reading and math proficiency, reading and math performance, underserved student performance, college curriculum breadth, and graduation rates. College readiness specifically measures participation and performance on Advanced Placement and International Baccalaureate exams.

Notably, the data used in this edition is from the 2018-2019 academic school year, so it was not affected by the COVID-19 pandemic.

"Families can use the Best High Schools rankings to see how schools compare at the national, state and local level on factors like graduation rates and college readiness," said Anita Narayan, managing editor of Education at U.S. News, in a statement. "The rankings also provide insight into academic performance among underserved groups showing how well schools are supporting these students."

Eight more Texas schools also appear on the national top 100 list:

  • No. 13, School for the Talented and Gifted, Dallas
  • No. 15, Irma Lerma Rangel Young Women's Leadership School, Dallas
  • No. 39, The Science and Engineering Magnet School, Dallas
  • No. 41, Liberal Arts and Science Academy, Austin
  • No. 42, Carnegie Vanguard High School, Houston
  • No. 46, DeBakey High School for Health Professions, Houston
  • No. 59, Judge Barefoot Sanders Law Magnet, Dallas
  • No. 68, IDEA Frontier College Preparatory, Brownsville
  • No. 89, Challenge Early College High School, Houston
  • No. 96, Health Careers High School, San Antonio
  • No. 97, Young Women's College Prep Academy, Houston
  • No. 98, Ann Richards School for Young Women Leaders, Austin

Just over the top 100 threshold is Grand Prairie Fine Arts Academy, coming in at No. 101.

Texas had 1,524 schools ranked this year, of which 42 placed in the top 5 percent, 79 in the top 10 percent, and 157 in the top 25 percent nationally.

Statewide, the top 10 highest ranking schools were:

  1. The School for the Talented and Gifted (TAG), Dallas
  2. Irma Lerma Rangel Young Women's Leadership School, Dallas
  3. Science and Engineering Magnet School (SEM), Dallas
  4. Liberal Arts and Science Academy (LASA), Austin
  5. Carnegie Vanguard High School, Houston
  6. DeBakey High School for Health Professions, Houston
  7. Judge Barefoot Sanders Law Magnet, Dallas
  8. IDEA Frontier College Preparatory, Brownsville
  9. Challenge Early College High School, Houston
  10. Health Careers High School, San Antonio

So, which school throughout the country ranks as this year's valedictorian? Thomas Jefferson High School for Science and Technology in Alexandria, Virginia was deemed the best in the country, as well as among magnet schools. Read the full report and search for schools here.

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This article originally ran on CultureMap.

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Houston digital health platform Koda lands strategic investment

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Houston-based advance care planning platform Koda Health has added another investor to the lineup.

The company secured a strategic investment for an undisclosed amount from UPMC Enterprises, the commercialization arm of the University of Pittsburgh Medical Center. The funding is part of Koda's oversubscribed series A funding round that closed in October, according to a release.

"UPMC Enterprises’ investment is a meaningful signal, not just to Koda, but to the broader market," Dr. Desh Mohan, chief medical officer and co-founder of Koda Health, said in the news release. "It validates that health systems are ready to invest in infrastructure that makes advance care planning work the way it should: proactively, at scale, and with the human support that these conversations require. Having UPMC Enterprises as a strategic investor puts us in a unique position to prove what's possible."

Koda has raised $14 million to date, according to a representative from the company. Its series A round was led by Evidenced, with participation from Mudita Venture Partners, Techstars and the Texas Medical Center last year. At the time, the company said the funding would allow it to scale operations and expand engineering, clinical strategy and customer success. The company described the round as a "pivotal moment," as it had secured investments from influential leaders in the healthcare and venture capital space.

Koda Health, which was born out of the TMC's Biodesign Fellowship in 2020, saw major growth last year, as well, and now supports more than 1 million patients nationwide through partnerships with Cigna Healthcare, Privia Health, Guidehealth, Sentara, UPMC and Memorial Hermann Health System.

The company integrated its end-of-life care planning platform with Dallas-based Guidehealth in April 2025 and with Epic Systems in July 2025. It also won the 2025 Houston Innovation Award in the Health Tech Business category. Read more here.

UH med school gets $2M gift and more top Houston innovation news

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Editor's note: The top Houston innovation news of the month is full of fresh funding, with two Texas medical schools receiving major gifts — one of historic proportions. Below are the five most-read InnovationMap headlines from April 16-30, 2026.

UH med school granted $2M gift to offer student scholarships

A new scholarship endowment aims to support students in the University of Houston’s recently established medical school. The University of Houston’s Tilman J. Fertitta Family College of Medicine received a planned estate gift commitment estimated at $2.1 million to establish the Bob Diehl and Teresa Evans Diehl Scholarship Endowment. The scholarship will assist full-time medical students who demonstrate financial need and meet academic standards. Continue reading.

How Houston innovators played a role in the historic Artemis II splashdown

Research from Rice University played a critical role in the safe return of U.S. astronauts aboard NASA’s Artemis II mission this month. Rice mechanical engineer Tayfun E. Tezduyar and longtime collaborator Kenji Takizawa developed a key computational parachute fluid-structure interaction (FSI) analysis system that proved vital in NASA’s Orion capsule’s descent into the Pacific Ocean. The FSI system, originally developed in 2013 alongside NASA Johnson Space Center, was critical in Orion’s three-parachute design, which slowed the capsule as it returned to Earth, according to Rice. Continue reading.

Baylor scientist lands $2M grant to explore links between viruses and Alzheimer’s

A Baylor College of Medicine scientist will begin exploring the possible link between Alzheimer’s disease and viral infections thanks to a $2 million grant awarded in March. Dr. Ryan S. Dhindsa hypothesizes that Alzheimer’s may have some link to previous viral infections contracted by the patient. To study this intriguing possibility, the American Brain Foundation has gifted him the Cure One, Cure Many award in neuroinflammation. Continue reading.

New UT Austin med center, anchored by MD Anderson, gets historic gift

A donation announced April 21 breaks a major record at the University of Texas at Austin. Michael and Susan Dell are now UT Austin's first supporters to give $1 billion. In response, the university will create the UT Dell Campus for Advanced Research and the UT Dell Medical Center to "advance human health," per a press release. Continue reading.

Houston VC funding surged nearly 50% in Q1 2026, report says

Houston saw a jump in VC funding in Q1 2026, fueled by several major investments in clean energy startups. Image via Getty Images

First-quarter venture capital funding for Houston-area startups climbed nearly 50 percent compared to the same time last year, according to the PitchBook-NVCA Venture Monitor. In Q1 2026, Houston-area startups raised $532.3 million, a 49 percent jump from $320.2 million in Q1 2025, according to the PitchBook-NVCA Venture Monitor. However, the Q1 total fell 23 percent from the $671.05 million raised in Q4 2025. Continue reading.

New 'living pharmacy' biotech company launches out of Rice venture studio

fighting cancer

Rice University’s biotech venture studio RBL LLC has launched a new “living pharmacy” company, Duracyte, designed to make cancer treatment easier on patients.

Backed by an up to $45 million Advanced Research Projects Agency for Health (ARPA-H) award, Duracyte aims to commercialize implantable biohybrid pharmacy devices that are designed to produce therapeutic proteins inside the human body around the clock, replacing the need for regular injections and infusions for some cancer patients.

The company’s main platform is its Hybrid Advanced Molecular Manufacturing Regulator (HAMMR), a rechargeable, implantable device that can sense biological signals, monitor tumor environments and adjust therapeutic output in real time. HAMMR has wireless communication capabilities, which allow patients and clinicians to remotely monitor results through an app every five minutes and make changes to treatment plans without a hosptial visit. Additionally, the device can generate its own oxygen supply, which is key for the therapeutic cells’ survival.

“Biologic medicines such as monoclonal antibodies, cytokines and metabolic regulators already account for a significant share of modern therapeutics, but the way we deliver them today often requires frequent injections or infusions that can be demanding for patients and lead to inconsistent drug levels,” Daniel Anderson, MIT professor and co-founder of Duracyte, said in a news release. “Our vision is to enable a continuous, stable therapy by producing these medicines directly inside the body, which could improve treatment consistency, reduce side effects and ultimately transform how biologic therapies are delivered across many diseases.”

Duracyte’s first clinical trial is slated to begin by the end of 2026 and will focus on recurrent ovarian cancer. The Phase I study will build upon existing work on encapsulated cytokine pharmacy technology, and the company hopes that within a few years this treatment can reach clinical application.

The development of Duracyte is supported by ARPA-H's Targeted Hybrid Oncotherapeutic Regulation (THOR) project, which supports a multidisciplinary research consortium co-led by Omid Veiseh, a professor of bioengineering at Rice. The consortium also includes others at Rice, The University of Texas MD Anderson Cancer Center, Stanford University, Carnegie Mellon University, Northwestern University and the University of Houston, plus industry collaborators like Chicago-based CellTrans.

“What we are building is the culmination of years of progress in cell engineering, biomaterials and implantable device technology,” Veiseh added in the release. “By combining these advances with real-time sensing and adaptive drug delivery, we are working with the support of RBL to create a true ‘living pharmacy’ that can deliver continuous, precisely controlled biologic therapies and fundamentally change how these treatments reach patients.”

RBL launched in 2024 and is based out of Houston’s Texas Medical Center Helix Park. Duracyte is the third company launched by RBL, including Sentinel BioTherapeutics, a clinical-stage immunotherapy company developing localized cytokine therapies for solid tumors, and SteerBio, a regenerative medicine company targeting lymphedema.

“Duracyte exemplifies the kind of breakthrough that Houston’s ecosystem is built to produce,” Paul Wotton, managing partner of RBL LLC and co-founder of Duracyte, added in the release. “With world-class clinical infrastructure, exceptional engineering talent and initiatives like the Texas Biotech Task Force driving alignment across industry, investment and talent, this region is uniquely positioned to move the most ambitious ideas in medicine from concept to patient, faster than anywhere else.”

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