Here's what Houston schools have been lauded for training the city's future leaders. Photo by skynesher/Getty Images

t's report card time, and four Houston high schools have made the grade, earning top 100 spots in this year's prestigious U.S. News & World Reportrankings of the Best U.S. High Schools. One even merited a special distinction.

Houston's Carnegie Vanguard High School ranked highest on the list at No. 42. The school is ranked fifth within Texas. The Advanced Placement coursework participation rate there is 100 percent; total minority enrollment is 77 percent, and 31 percent of students are economically disadvantaged.

Following close behind is the prestigious DeBakey High School for Health Professions at No. 46 overall. The renowned medical prep school boasts an AP participation rate of 98 percent, total minority enrollment is 88 percent, and 44 percent of students are economically disadvantaged.

Farther down the list is Challenge Early College High School, at No. 89 overall. The AP participation rate here is 100 percent, total minority enrollment is 92 percent, and 76 percent of students are economically disadvantaged.

At No. 97 overall is Young Women's College Prep Academy. The AP participation rate here is 100 percent. The total minority enrollment is 97 percent, and nearly all students — some 96 percent — are economically disadvantaged.

The 2021 edition is U.S. News' most comprehensive survey yet, with the consumer advice outlet evaluating more than 17,800 public high schools on how well they serve all of their students, regardless of economic or ethnic background.

To determine rankings, they focus on six factors: college readiness, reading and math proficiency, reading and math performance, underserved student performance, college curriculum breadth, and graduation rates. College readiness specifically measures participation and performance on Advanced Placement and International Baccalaureate exams.

Notably, the data used in this edition is from the 2018-2019 academic school year, so it was not affected by the COVID-19 pandemic.

"Families can use the Best High Schools rankings to see how schools compare at the national, state and local level on factors like graduation rates and college readiness," said Anita Narayan, managing editor of Education at U.S. News, in a statement. "The rankings also provide insight into academic performance among underserved groups showing how well schools are supporting these students."

Eight more Texas schools also appear on the national top 100 list:

  • No. 13, School for the Talented and Gifted, Dallas
  • No. 15, Irma Lerma Rangel Young Women's Leadership School, Dallas
  • No. 39, The Science and Engineering Magnet School, Dallas
  • No. 41, Liberal Arts and Science Academy, Austin
  • No. 42, Carnegie Vanguard High School, Houston
  • No. 46, DeBakey High School for Health Professions, Houston
  • No. 59, Judge Barefoot Sanders Law Magnet, Dallas
  • No. 68, IDEA Frontier College Preparatory, Brownsville
  • No. 89, Challenge Early College High School, Houston
  • No. 96, Health Careers High School, San Antonio
  • No. 97, Young Women's College Prep Academy, Houston
  • No. 98, Ann Richards School for Young Women Leaders, Austin

Just over the top 100 threshold is Grand Prairie Fine Arts Academy, coming in at No. 101.

Texas had 1,524 schools ranked this year, of which 42 placed in the top 5 percent, 79 in the top 10 percent, and 157 in the top 25 percent nationally.

Statewide, the top 10 highest ranking schools were:

  1. The School for the Talented and Gifted (TAG), Dallas
  2. Irma Lerma Rangel Young Women's Leadership School, Dallas
  3. Science and Engineering Magnet School (SEM), Dallas
  4. Liberal Arts and Science Academy (LASA), Austin
  5. Carnegie Vanguard High School, Houston
  6. DeBakey High School for Health Professions, Houston
  7. Judge Barefoot Sanders Law Magnet, Dallas
  8. IDEA Frontier College Preparatory, Brownsville
  9. Challenge Early College High School, Houston
  10. Health Careers High School, San Antonio

So, which school throughout the country ranks as this year's valedictorian? Thomas Jefferson High School for Science and Technology in Alexandria, Virginia was deemed the best in the country, as well as among magnet schools. Read the full report and search for schools here.

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This article originally ran on CultureMap.

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”