This week's roundup of Houston innovators includes Megan Eddings of Accel Lifestyle, David Gow of the Center for Houston's Future, and Tim Latimer of Fervo Energy. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a Houston entrepreneur, a media businessman turned nonprofit leader, and growing geothermal energy company founder.

Megan Eddings, founder of Accel Lifestyle

Megan Eddings shares the full entrepreneurial journey — from founding to a pandemic pivot and an exit — on the Houston Innovators Podcast. Photo courtesy of Megan Eddings

After years of tolling over her athleisure wear startup, Megan Eddings knew what her company needed for it to be successful, and she knew she wasn't the right person to do it.

Accel Lifestyle, a clothing brand based on Edding's patented antimicrobial Prema fabric, launched late in 2019 just ahead of boutique fitness studio craze was significantly affected by the pandemic. After pivoting to face masks, including manufacturing tens of thousands for the United States Military, Eddings says she went into the next few years with Accel being back on track to design stink-resistant workout clothing.

But Eddings knew the company needed a huge marketing push to make a splash in the direct-to-consumer world.

"The core of who I am is not a social media person," she says on the Houston Innovators Podcast. "That isn't my skillset. If you sell a product, one of the only ways to become wildly successful is to have an incredible marketing strategy that you need a lot of money to build and create. That is not something that I liked.

"I was so passionate about inventing something, but in order to really scale to the next level, I would have had to take on quite a bit of investment money," she continues. Read more.

David Gow, president and CEO of the Center for Houston's Future

David Gow has been named president and CEO of the Center for Houston's Future. His role is effective September 3.Photo via CultureMap

A nonprofit organization dedicated to leading Houston into the future has named its next leader.

The Center for Houston’s Future named David Gow as president and CEO, succeeding Brett Perlman, who was announced in April to be remaining at the Center with a focus on the Center’s hydrogen initiative. Gow is the founder and chairman of Gow Media, InnovationMap's parent company. His role is effective September 3.

“I am excited to step into this opportunity with the Center and work with the team, the board and many other stakeholders to help shape Houston’s future,” Gow says in a news release. “The Center presents an exciting opportunity to cast a vision for our region and identify initiatives that will make an impact.”Read more.

Tim Latimer, co-founder and CEO of Fervo Energy

Tim Latimer's Fervo Energy went from a 5,158-square-foot space to a 23,782-square-foot office in downtown Houston. Photo courtesy of Fervo Energy

On the heels of landing more than $240 million in venture capital, Houston-based geothermal power provider Fervo Energy has more than quadrupled the size of its headquarters.

Fervo previously occupied 5,158 square feet at 114 Main St. in downtown Houston. The company recently left the Main Street space and leased 23,782 square feet at downtown Houston’s 910 Louisiana office tower. Houston-based commercial real estate company Hines owns and manages the 50-story former One Shell Plaza.

“We believe Houston is the center of the energy transition, and downtown Houston has long been its center of activity,” Tim Latimer, co-founder and CEO of Fervo Energy, says in a news release. “The availability of dining options, parks, and biking infrastructure continue to be great assets and a huge draw for our team. For these reasons and more, the only place for Fervo’s headquarters is downtown Houston.” Read more.

What can hospital systems do to combat climate change? A lot, according to a new report from the Center for Houston's Future. Photo via Getty Images

New report calls for Houston health care community to take action amid climate change

time for action

A new report underscores an “urgent need” for health care systems in the Houston area to combat climate change and avoid an environmental “code blue.”

“By adopting collaborative strategies and leveraging technological innovations, health care providers can play a pivotal role in safeguarding the health of Houston’s residents against the backdrop of an evolving climate landscape,” says the report, published by the Center for Houston’s Future.

Among the report’s recommendations are:

  • Advocate for policies that promote decarbonization.
  • Create eco-friendly spaces at hospitals and in low-income communities, among other places.
  • Recruit “champions” among health leaders and physicians to help battle climate change.
  • Establish academic programs to educate health care professionals and students about climate health and decarbonization.
  • Bolster research surrounding climate change.
  • Benchmark, track, and publish statistics about greenhouse gas emissions “to foster accountability and reduce environmental impacts of the health care sector.” The report notes that the U.S. health care sector emits 8.5 percent of the country’s greenhouse gases.

“By embracing collaborative strategies, acting with urgency and implementing sustainable practices, our region’s health care providers can play a pivotal role in creating a healthier, more resilient Houston,” says Brett Perlman, outgoing president and CEO of the Center for Houston’s Future. “If we work together, given all the collective wisdom, resources and innovation concentrated in our medical community, we can tackle the challenges that are confronting us.”

The report highlights the threat of climate-driven disasters in the Houston area, such as extreme heat, floods, and hurricanes. These events are likely to aggravate health issues like heatstroke, respiratory illnesses, cardiovascular diseases, and insect-borne diseases, says the report.

St. Luke’s Health, a nonprofit health care system with 16 hospitals in the Houston area and East Texas, provided funding for the report.

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This article originally ran on EnergyCapital.

These organizations are teaming up to advance development of a regional clean industrial hub. Photo by Katya Horner

Houston organizations announce new partner, plans for clean industrial hub

seeing green

Two Houston organizations that are on a mission to make Houston a leader in the energy transition have announced new plans for a hub focused on decarbonization.

The Houston Energy Transition Initiative and the Center for Houston’s Future have teamed up with the Mission Possible Partnership, with support from the Bezos Earth Fund, to lead the city of Houston through the accelerated development of a regional clean industrial hub geared at decarbonization of the industrial sector, including petrochemicals, cement plants, heavy transportation, and more.

The two-year project is focused on development and deployment of clean energy projects — such as "low-carbon hydrogen, carbon capture, use and storage, electrification of industrial processes, and the production and use of low carbon fuels," according to a press release.

“There is no geography in the world better positioned to support the transition to and integration of abundant, low-carbon energy solutions than Houston," says Jane Stricker, executive director and senior vice president of HETI, in the release. "As the Energy Transition Capital of the World, Houston is leveraging its energy leadership to accelerate global solutions for a low-carbon future. This partnership with MPP is a critical component in the region’s efforts to develop and deploy technologies, policies and strategies for broad decarbonization."

MPP, a nonprofit alliance of climate leaders launched in 2020 focused on energizing decarbonization, is supported by RMI, the Bezos Earth Fund, the Energy Transition Commission, World Economic Forum, and We Mean Business.

“The Center for Houston’s Future has been leading HETI’s clean hydrogen initiative with the goal of making Houston a global clean hydrogen leader," says Brett Perlman, CEO of the Center for Houston’s Future. "We’re now pleased to work with Mission Possible Project and leverage the MPP team’s deep subject matter expertise in clean hydrogen and experience in creating hydrogen ecosystems."

In October, HETI released a report calling for the region to aim for $150 billion in capital earmarked for the sector by 2040. The report indicated that about $15 billion in energy transition capital is flowing into the region each year and about $25 billion is flowing out of the region. Of the $25 billion, oil and gas players with headquarters or a significant presence in Houston account for more than 80 percent.

“Increased energy transition capital commitment from energy incumbents raises investor confidence in Houston’s potential for energy transition leadership,” reads the report.

The Center for Houston's Future had a report of its own that published earlier this year and makes the argument of how Houston-based assets can be leveraged to lead a global clean hydrogen innovation.

“It should come as no surprise that Houston, the energy capital of the world, is taking the lead in the emerging low emissions energy ecosystem,” says Bryan Fisher, director of hubs at MPP and managing director of RMI’s Climate-Aligned Industries, in the release. “MPP’s work with HETI and the Center for Houston’s Future will focus on a portfolio of solutions, including low carbon fuels, clean hydrogen, and CCUS to drive sustainability and equitable economic growth for the region.”

The Center for Houston's Future is a part of a collaboration that has established a hub for hydrogen innovation. Image via Getty Images

Houston organization leads collaboration to advance Gulf Coast clean hydrogen projects

H-town

A handful of organizations have joined forces to create a new hub for the advancement of clean hydrogen projects in Texas, Southwest Louisiana, and the surrounding Gulf Coast region.

The HyVelocity Hub announced last week that it is applying for U.S. Department of Energy Regional Clean Hydrogen Hub funding. GTI Energy, The Center for Houston’s Future, The University of Texas at Austin, Air Liquide, and Chevron are among the founding members of the HyVelocity Hub.

“The name ‘HyVelocity’ conveys the idea that we have a tremendous opportunity to accelerate the creation of a clean hydrogen market at the pace needed to meet aggressive decarbonization goals for communities in our nation and around the globe,” says Paula A. Gant, president and CEO of Illinois GTI Energy, in a news release. “We need hydrogen deployment at scale, and this hub will lay the foundation with complete end-to-end demonstrations of an integrated network, match supply and demand regionally or locally, and leverage existing infrastructure to deliver resilient, reliable, and sustainable clean energy.”

The Gulf Coast is already a leader in hydrogen production, per the release, and the region is home to a diverse array of energy resources, including hydrogen production facilities and pipelines, a large base of industrial energy consumers, and a skilled, technical workforce.

“We are pleased to be partnering with our colleagues at GTI Energy in creating HyVelocity Hub as the implementation platform for the shared vision of a Texas-sized global clean hydrogen ecosystem created by our collaborative stakeholder process," says Brett Perlman, CEO of The Center for Houston’s Future in the release. “The realization of this vision will be achieved faster with clean hydrogen hub funding under the Bipartisan Infrastructure Law.”

Earlier this year, the Center for Houston's Future released a report that outlined what it will take for Houston to establish itself as a hub for hydrogen innovation as well as the impact this industry can have on Houston's economy. The HyVelocity Hub will engage environmental and social justice organizations in the Gulf Coast region to grow the local economy and create jobs in disadvantaged communities, according to the release.

“Accelerating clean energy technologies is vital to addressing global climate challenges as well as local air quality, and Port Houston is excited to participate in advancing these efforts with the HyVelocity Hub,” says Rich Byrnes, chief infrastructure officer of Port Houston, in the release. “The Hub will benefit trucking and maritime sectors, and our communities tremendously with cleaner transportation, lower emissions, new jobs, and both social and environmental equity."

There's a lot of clean tech potential in hydrogen — and Houston might be the place to lead the way. Image via Getty Images

New report shows why now is the time for Houston to emerge as a hub for hydrogen innovation

clean energy

Houston, known for being the energy capital of the world, has potential to lead innovation within the hydrogen space, and a new report lays out how.

The report, which was released today by the Center for Houston’s Future, is titled "Houston as the epicenter of a global clean hydrogen hub." The information explains how Houston-based assets can be leveraged to lead a global clean hydrogen innovation.

“The Houston region has the talent, expertise and infrastructure needed to lead the global energy transition to a low-carbon world. Clean hydrogen, alongside carbon capture, use, and storage are among the key technology areas where Houston is set up to succeed and can be an example to other leading energy economies around the world,” says Bobby Tudor, chair of the Greater Houston Partnership’s Houston Energy Transition Initiative, in a news release.

Together, GHP's HETI and over 100 experts representing 70 companies and organizations produced the report, along with McKinsey and Company, which donated significant research and economic analyses. Here are some highlights from the study, according to the release:

  • Clean hydrogen production could grow 5 times over current hydrogen production by 2050.
  • The establishment of a clean hydrogen industry could create 180,000 jobs (direct, indirect and induced) statewide, while adding $100 billion to Texas' GDP growth.
  • Globally, a Houston-led clean hydrogen hub could abate 220 million tons (MT) tons of carbon emissions by 2050.

“This report gives additional weight to the already strong case that Houston is uniquely positioned to lead a transformational clean hydrogen hub with global impact,” says Houston Mayor Sylvester Turner. “We can also deliver economic growth, create jobs and cut emissions across Houston and the Gulf Coast, including in underserved communities.”

The Houston region already produces and consumes a third of the nation’s hydrogen, per the release, and has more than 50 percent of the country’s dedicated hydrogen pipelines. These assets can be utilized to accelerate a transition to clean hydrogen, and the report lays out how.

"Using this roadmap as a guide and with Houston’s energy sector at the lead, we are ready to create a new clean hydrogen economy that will help fight climate change as it creates jobs and economic growth,” says Center for Houston’s Future CEO Brett Perlman. “We are more than ready, able and willing to take on these goals, as our record of overwhelming success in energy innovation and new market development shows.”

Check out these conferences, pitch events, networking, and more happening in Houston in the month of April. Photo via Getty Images

10+ can't-miss Houston business and innovation events for April

where to be

After a very busy March, Houston innovators might need to prepare for another month of networking opportunities. Here's a rundown of what all to throw on your calendar for April.

This article will be updated as more business and tech events are announced.

April 5-6 — Energy CEO Summit

Industry leaders and members of the Houston business community will discuss the evolution of the energy sector, Houston's pivotal role, and the critical events driving the change.

Center for Houston's Future CEO Brett Perlman will moderate a panel on Electrical Grid Trends at 9:30 a.m. on Wednesday, April 6.

The event is Tuesday and Wednesday, April 5-6, online or at Asia Society Texas Center (1370 Southmore Blvd.). Click here to register.

April 6 — 2022 PVAMU Industry Innovation Collaboration Day

This event is designed to provide an interactive platform for academicians, researchers, students, industries, and government agencies an opportunity to meet and share recent innovations, developments, and technology trends. Collaboration between the university and various industries needs to be nourished to enhance innovation development for the benefit of society.

The event is Wednesday, April 6, from 8:30 am to 5 pm at Prairie View A&M University-MSC Ballroom (155 L.W Minor St.). Click here to register.

April 6 — Enventure "Inspire" Seminar Series - With Dr. Santosh A. Helekar, MD, PhD

The "Inspire" Seminar Series was developed by Enventure to help students learn about the reality of working in the biotech and biomedical fields. The series consists of a number of events starring guest speakers coming from different areas in the biotech and biomedical industries.

This particular event will star Dr. Santosh A. Helekar, M.D., Ph.D. Participants attending this event will learn about the story of Dr. Helekar and his experiences from transitioning from grad school & academia into an inventor & his experiences and current role. In addition, there will be a final Q&A where the audience will be able to ask direct questions to Dr. Helekar.

The online event is Wednesday, April 6, from 6 to 7:30 pm. Click here to register.

April 7 — Low-Carbon Hydrogen Accelerator Kickoff

Together with Greentown Labs and the Urban Future Lab, EPRI and Shell recognize the need to accelerate the development and commercialization of low-carbon technologies required to enable economy-wide decarbonization. As leaders in the utilities and energy industries, respectively, with domain expertise, R&D facilities, and access to global customers, EPRI and Shell are uniquely positioned to lead this transformation in partnership with startups innovating at the cutting edge of low-carbon hydrogen.

The hybrid event is Thursday, April 7, from 5:30 to 8 pm at Greentown Labs (4200 San Jacinto St.) and streaming online. Click here to register.

April 7-9 — 2022 Rice Business Plan Competition

The 2022 Rice Business Plan Competition will be hosted in Houston at the Jones Graduate School of Business. This year, 42 teams have been invited to compete in the 22nd Annual Competition. The finals will be streamed online —watch on Saturday, April 9 on our YouTube. If you're a member, please visit our membership page to register to attend in-person.

The competition is held Thursday through Saturday, April 7-9, at Rice University (6100 Main St.) and streamed online. Click here to register.

April 12 — Energy & Energy 2.0 Council

As the Energy Capital of the World, Houston is the headquarters and the intellectual capital for virtually every segment of the energy industry including exploration, production, transmission, marketing, supply, and technology. This Council explores how Houston's largest industry continues to lead in this critical sector while also advancing innovation that supports the transition to a more efficient and sustainable, low-carbon future that also accommodates global demand growth.

The event is Tuesday, April 12, from 11:30 am to 1 pm at Partnership Tower (701 Avenida de las Americas, Suite 900). Click here to register.

April 12 — Softeq Venture Studio Demo Day (Q1 2022 Cohort)

The Softeq Venture Studio invested $125,000 in cash and services in each of the nine early-stage startups to help them refine their business model, build their technology, and prepare them to scale. In this capstone event, founders have seven minutes each to present their pitch deck, demo their product, outline their ask, and answer questions. And we need you there to evaluate them for investment (or at least support them).

The event is Tuesday, April 12, from 5 to 7:30 pm at The Ion (4201 Main St.). Click here to register.

April 13 — Serving & Selling: Building your Brand, brought to you by Insperity

Find out how to solidify your brand, deliver exceptional service, and take your productivity to the next level, with Pete Hinojosa, CBPA.

The event is Wednesday, April 13, from 1:30 to 2:30 pm at The Cannon (1334 Brittmore Dr.). Click here to register.

April 14 — DivInc Happy Hour: Meet the Sports Tech Cohort

Meet DivInc's Sports Tech cohort at a happy hour hosted at The Ion on April 14. The companies accepted into the new cohort are slated to be announced on April 11.

The event is Thursday, April 14, at 5:30 pm at The Ion (4201 Main St.). Click here to register.

April 19 — State of Technology

The second annual Greater Houston Partnership event features business leaders discussing Houston's growth as a national leader in tech innovation and the many qualities the region possesses that support a robust tech ecosystem. Through a panel discussion, the event will also explore how Houston is uniquely enabling digital transformation across industries including energy, life sciences and healthcare, manufacturing, logistics, and aerospace.

The event is Tuesday, April 19, at 10 am to 1:30 pm at Hilton Americas (1600 Lamar St.). Click here to register.

April 20 — Spring 2022 D2K Showcase

Explore Rice University's D2K students’ end-of-semester projects covering a wide range of topics including computer vision, natural language processing, deep learning applications, web scraping, time series analysis, signal processing and more. Celebrate the impact they are making through data science and interact with Rice students and learn more about their projects in the poster session. Attendees can vote for their favorite project/team to compete for cash prizes.

The event is Wednesday, April 20, from 5 to 7 pm at Duncan Hall at Rice University (6100 Main St.). Click here to register.

April 20 — The H. Albert Napier Rice Launch Challenge Championships

Join Liu Idea Lab for Innovation and Entrepreneurship and support Rice University student startups at the H. Albert Napier Rice Launch Challenge Championships on Wednesday, April 20. Six student finalists will pitch their ventures for the chance to win a share of $75,000+ in equity-free funding. Attendance is open to Rice students, Rice alumni, friends of Rice, and the whole Houston entrepreneurial community. Seats are limited, so get your tickets while you still can.

The event is Wednesday, April 20, from 5:30 to 9 pm at The Anderson-Clarke Center’s Hudspeth Auditorium (6100 Main St.). Click here to register.

April 21 — Greentown Houston's First Anniversary

A year after opening the Houston's first-ever climatetech startup incubator, Greentown Houston is home to over 60 startup members and 20 corporate partners. Join the green tech hub for a celebration of entrepreneurship, collaboration, and innovation, which together with the engineering strength and talent of the region’s energy industry will power Houston’s climate leadership. The day of festivities will include celebratory remarks, lightning pitches from some of our outstanding startups, a member showcase, networking, and more.

The event is Thursday, April 21, from 1 to 7 pm, at Greentown Houston (4200 San Jacinto St.) or livestreaming online. Click here to register.

April 27 — Engage VC: Revolution

Revolution is a D.C.-based investment firm focused on investing in entrepreneurs building transformative companies outside of Silicon Valley. With $1.7 billion of capital commitments across portfolio companies including Houston-based Goodfair and relationships in 60+ startup communities, Revolution is dedicated to creating meaningful results for companies outside of the Bay Area. And they are coming to Houston. Join HX Venture Fund to hear Tige Savage, Co-Founder & Managing Partner at Revolution Ventures, David Hall, Managing Partner at Revolution's Rise of the Rest Seed Fund, and Martin Simoncic, President B2B at PROS discuss Revolution's perspective on venture investing, current and future trends, and how Houston fits in among other topics.

The event is Wednesday, April 27, at 8:30 to 10 am at The Ion (4201 Main St.). Click here to register.


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Houston leaders form coalition to boost Texas power grid with new tech

a better grid

A Houston-based coalition that launched this month aims to educate Texas officials about technology designed to shore up the state’s power grid.

The public-private Texas Reliability Coalition says it will promote utility-scale microgrid technology geared toward strengthening the resilience and reliability of the Texas power grid, particularly during extreme weather.

A utility-operated microgrid is a group of interconnected power loads and distributed energy sources that can operate in tandem with or apart from regular power grids, such as the grid run by the Electric Reliability Council of Texas (ERCOT). Legislation passed in 2023 enables the use of utility-scale microgrid technology in Texas’ deregulated energy market, according to the coalition.

John Elder, executive director of the coalition, says that with the legal framework now in place, the Public Utility Commission of Texas and ERCOT need to create rules to establish the Texas marketplace for microgrid technology. The goal, he says, is to “take the Texas grid from good to great” by installing microgrid technology, improving the infrastructure, and strengthening the system — all targeted toward meeting power needs during extreme weather and amid growing demand.

Houston-based CenterPoint Energy will test the utility-scale microgrid technology being promoted by the coalition. In a January 31 filing with the Public Utility Commission, CenterPoint says microgrid technology will be featured in a $36.5 million pilot program that’ll set up an estimated three to five microgrids in the company’s service area. The pilot program is slated to last from 2026 to 2028.

In the public affairs arena, five Houston executives are leading the new reliability commission’s microgrid initiative.

Elder, one of the coalition’s founding members, is president and CEO of Houston-based Acclaim Energy. Other founders include Ember Real Estate Investment & Development, Park Eight Development, and PowerSecure. Ember and Park Eight are based in Houston. Durham, North Carolina-based PowerSecure, which produces microgrid technology, is a subsidiary of energy provider Southern Co.

Aside from Elder, members of the coalition’s board are:

  • Stewart Black, board secretary of the coalition and vice president of Acclaim Energy’s midstream division
  • Todd Burrer, president of municipal utility districts at Inframark
  • Harry Masterson, managing principal of Ember
  • Martin Narendorf, former vice president at CenterPoint Energy

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This article originally appeared on our sister site, EnergyCapital.

This Houston neighbor is the fastest growing wealthy suburb in America

By The Numbers

The Houston-area city of Fulshear is booming like nowhere else: It's now the No. 1 fast-growing affluent suburb in the country.

Fulshear's No. 1 status was unveiled in a new GoBankingRates' study that ranked the "30 Fastest Growing Wealthy Suburbs in America" for 2025. The report examined population changes from 2018 to 2023 among cities and towns in major U.S. metro areas with populations between 25,000 and 100,000 residents. Median household income, average home value, and a "livability score" were also calculated for each locale.

Fulshear, located 34 miles west of downtown Houston, experienced the most dramatic population increase out of all 30 cities in the report. Though the suburb only has an estimated population of 42,616 residents, that number has skyrocketed 237 percent during the five-year period.

A Fulshear resident's median income is $178,398 annually, and the average value of a home in the city comes out to $521,157, the report additionally found.

Fulshear was the second fastest growing city in America in 2023. The city's growth is further reflected by the number of new apartments that were built in the area in 2024.

Texas is tops
Texas cities took the top three fastest growing U.S. suburbs for 2025, with Dallas-area cities of Celina (No. 2) and Prosper (No. 3) experiencing wildly different (yet still sky high) population changes. Celina's population ballooned 190 percent to 43,317 residents, while Prosper's grew 81 percent to an estimated 41,660 people.

Other Texas cities that earned spots in the report include Flower Mound (No. 19), Southlake (No. 27), University Park (No. 28) and Colleyville (No. 29), all in the Dallas-Fort Worth area.

"The old adage that everything is bigger in Texas is true, considering the number of Lone Star State suburbs that are quickly growing in population and overall wealth," the report's author wrote.

The top 10 fastest growing wealthy suburbs in America are:

  • No. 1 – Fulshear, Texas
  • No. 2 – Celina, Texas
  • No. 3 – Prosper, Texas
  • No. 4 – Erie, Colorado
  • No. 5 – Clarksburg, Maryland
  • No. 6 – Zionsville, Indiana
  • No. 7 – Redmond, Washington
  • No. 8 – Dublin, California
  • No. 9 – Parkland, Florida
  • No. 10 – Eastvale, California
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This story originally appeared on our sister site CultureMap.com.

Rice research breakthrough paves the way for advanced disease therapies

study up

Bioengineers at Rice University have developed a “new construction kit” for building custom sense-and-respond circuits in human cells, representing a major breakthrough in the field of synthetic biology, which could "revolutionize" autoimmune disease and cancer therapeutics.

In a study published in the journal Science, the team focused on phosphorylation, a cellular process in the body in which a phosphate group is added to a protein, signaling a response. In multicellular organisms, phosphorylation-based signaling can involve a multistage, or a cascading-like effect. Rice’s team set out to show that each cycle in a cascade can be treated as an elementary unit, meaning that they can be reassembled in new configurations to form entirely novel pathways linking cellular inputs and outputs.

Previous research on using phosphorylation-based signaling for therapeutic purposes has focused on re-engineering pathways.

“This opens up the signaling circuit design space dramatically,” Caleb Bashor, assistant professor of bioengineering and biosciences and corresponding author on the study, said in a news release. “It turns out, phosphorylation cycles are not just interconnected but interconnectable … Our design strategy enabled us to engineer synthetic phosphorylation circuits that are not only highly tunable but that can also function in parallel with cells’ own processes without impacting their viability or growth rate.”

Bashor is the deputy director for the Rice Synthetic Biology Institute, which launched last year.

The Rice lab's sense-and-respond cellular circuit design is also innovative because phosphorylation occurs rapidly. Thus, the new circuits could potentially be programmed to respond to physiological events in minutes, compared to other methods, which take hours to activate.

Rice’s team successfully tested the circuits for sensitivity and their ability to respond to external signals, such as inflammatory issues. The researchers then used the framework to engineer a cellular circuit that can detect certain factors, control autoimmune flare-ups and reduce immunotherapy-associated toxicity.

“This work brings us a whole lot closer to being able to build ‘smart cells’ that can detect signs of disease and immediately release customizable treatments in response,” Xiaoyu Yang, a graduate student in the Systems, Synthetic and Physical Biology Ph.D. program at Rice who is the lead author on the study, said in a news release.

Ajo-Franklin, a professor of biosciences, bioengineering, chemical and biomolecular engineering and a Cancer Prevention and Research Institute of Texas Scholar, added “the Bashor lab’s work vaults us forward to a new frontier — controlling mammalian cells’ immediate response to change.”