3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Megan Eddings of Accel Lifestyle, David Gow of the Center for Houston's Future, and Tim Latimer of Fervo Energy. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a Houston entrepreneur, a media businessman turned nonprofit leader, and growing geothermal energy company founder.

Megan Eddings, founder of Accel Lifestyle

Megan Eddings shares the full entrepreneurial journey — from founding to a pandemic pivot and an exit — on the Houston Innovators Podcast. Photo courtesy of Megan Eddings

After years of tolling over her athleisure wear startup, Megan Eddings knew what her company needed for it to be successful, and she knew she wasn't the right person to do it.

Accel Lifestyle, a clothing brand based on Edding's patented antimicrobial Prema fabric, launched late in 2019 just ahead of boutique fitness studio craze was significantly affected by the pandemic. After pivoting to face masks, including manufacturing tens of thousands for the United States Military, Eddings says she went into the next few years with Accel being back on track to design stink-resistant workout clothing.

But Eddings knew the company needed a huge marketing push to make a splash in the direct-to-consumer world.

"The core of who I am is not a social media person," she says on the Houston Innovators Podcast. "That isn't my skillset. If you sell a product, one of the only ways to become wildly successful is to have an incredible marketing strategy that you need a lot of money to build and create. That is not something that I liked.

"I was so passionate about inventing something, but in order to really scale to the next level, I would have had to take on quite a bit of investment money," she continues. Read more.

David Gow, president and CEO of the Center for Houston's Future

David Gow has been named president and CEO of the Center for Houston's Future. His role is effective September 3.Photo via CultureMap

A nonprofit organization dedicated to leading Houston into the future has named its next leader.

The Center for Houston’s Future named David Gow as president and CEO, succeeding Brett Perlman, who was announced in April to be remaining at the Center with a focus on the Center’s hydrogen initiative. Gow is the founder and chairman of Gow Media, InnovationMap's parent company. His role is effective September 3.

“I am excited to step into this opportunity with the Center and work with the team, the board and many other stakeholders to help shape Houston’s future,” Gow says in a news release. “The Center presents an exciting opportunity to cast a vision for our region and identify initiatives that will make an impact.”Read more.

Tim Latimer, co-founder and CEO of Fervo Energy

Tim Latimer's Fervo Energy went from a 5,158-square-foot space to a 23,782-square-foot office in downtown Houston. Photo courtesy of Fervo Energy

On the heels of landing more than $240 million in venture capital, Houston-based geothermal power provider Fervo Energy has more than quadrupled the size of its headquarters.

Fervo previously occupied 5,158 square feet at 114 Main St. in downtown Houston. The company recently left the Main Street space and leased 23,782 square feet at downtown Houston’s 910 Louisiana office tower. Houston-based commercial real estate company Hines owns and manages the 50-story former One Shell Plaza.

“We believe Houston is the center of the energy transition, and downtown Houston has long been its center of activity,” Tim Latimer, co-founder and CEO of Fervo Energy, says in a news release. “The availability of dining options, parks, and biking infrastructure continue to be great assets and a huge draw for our team. For these reasons and more, the only place for Fervo’s headquarters is downtown Houston.” Read more.

What can hospital systems do to combat climate change? A lot, according to a new report from the Center for Houston's Future. Photo via Getty Images

New report calls for Houston health care community to take action amid climate change

time for action

A new report underscores an “urgent need” for health care systems in the Houston area to combat climate change and avoid an environmental “code blue.”

“By adopting collaborative strategies and leveraging technological innovations, health care providers can play a pivotal role in safeguarding the health of Houston’s residents against the backdrop of an evolving climate landscape,” says the report, published by the Center for Houston’s Future.

Among the report’s recommendations are:

Advocate for policies that promote decarbonization.
Create eco-friendly spaces at hospitals and in low-income communities, among other places.
Recruit “champions” among health leaders and physicians to help battle climate change.
Establish academic programs to educate health care professionals and students about climate health and decarbonization.
Bolster research surrounding climate change.
Benchmark, track, and publish statistics about greenhouse gas emissions “to foster accountability and reduce environmental impacts of the health care sector.” The report notes that the U.S. health care sector emits 8.5 percent of the country’s greenhouse gases.

“By embracing collaborative strategies, acting with urgency and implementing sustainable practices, our region’s health care providers can play a pivotal role in creating a healthier, more resilient Houston,” says Brett Perlman, outgoing president and CEO of the Center for Houston’s Future. “If we work together, given all the collective wisdom, resources and innovation concentrated in our medical community, we can tackle the challenges that are confronting us.”

The report highlights the threat of climate-driven disasters in the Houston area, such as extreme heat, floods, and hurricanes. These events are likely to aggravate health issues like heatstroke, respiratory illnesses, cardiovascular diseases, and insect-borne diseases, says the report.

St. Luke’s Health, a nonprofit health care system with 16 hospitals in the Houston area and East Texas, provided funding for the report.

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This article originally ran on EnergyCapital.

These organizations are teaming up to advance development of a regional clean industrial hub. Photo by Katya Horner

Houston organizations announce new partner, plans for clean industrial hub

seeing green

Two Houston organizations that are on a mission to make Houston a leader in the energy transition have announced new plans for a hub focused on decarbonization.

The Houston Energy Transition Initiative and the Center for Houston’s Future have teamed up with the Mission Possible Partnership, with support from the Bezos Earth Fund, to lead the city of Houston through the accelerated development of a regional clean industrial hub geared at decarbonization of the industrial sector, including petrochemicals, cement plants, heavy transportation, and more.

The two-year project is focused on development and deployment of clean energy projects — such as "low-carbon hydrogen, carbon capture, use and storage, electrification of industrial processes, and the production and use of low carbon fuels," according to a press release.

“There is no geography in the world better positioned to support the transition to and integration of abundant, low-carbon energy solutions than Houston," says Jane Stricker, executive director and senior vice president of HETI, in the release. "As the Energy Transition Capital of the World, Houston is leveraging its energy leadership to accelerate global solutions for a low-carbon future. This partnership with MPP is a critical component in the region’s efforts to develop and deploy technologies, policies and strategies for broad decarbonization."

MPP, a nonprofit alliance of climate leaders launched in 2020 focused on energizing decarbonization, is supported by RMI, the Bezos Earth Fund, the Energy Transition Commission, World Economic Forum, and We Mean Business.

“The Center for Houston’s Future has been leading HETI’s clean hydrogen initiative with the goal of making Houston a global clean hydrogen leader," says Brett Perlman, CEO of the Center for Houston’s Future. "We’re now pleased to work with Mission Possible Project and leverage the MPP team’s deep subject matter expertise in clean hydrogen and experience in creating hydrogen ecosystems."

In October, HETI released a report calling for the region to aim for $150 billion in capital earmarked for the sector by 2040. The report indicated that about $15 billion in energy transition capital is flowing into the region each year and about $25 billion is flowing out of the region. Of the $25 billion, oil and gas players with headquarters or a significant presence in Houston account for more than 80 percent.

“Increased energy transition capital commitment from energy incumbents raises investor confidence in Houston’s potential for energy transition leadership,” reads the report.

The Center for Houston's Future had a report of its own that published earlier this year and makes the argument of how Houston-based assets can be leveraged to lead a global clean hydrogen innovation.

“It should come as no surprise that Houston, the energy capital of the world, is taking the lead in the emerging low emissions energy ecosystem,” says Bryan Fisher, director of hubs at MPP and managing director of RMI’s Climate-Aligned Industries, in the release. “MPP’s work with HETI and the Center for Houston’s Future will focus on a portfolio of solutions, including low carbon fuels, clean hydrogen, and CCUS to drive sustainability and equitable economic growth for the region.”

The Center for Houston's Future is a part of a collaboration that has established a hub for hydrogen innovation. Image via Getty Images

Houston organization leads collaboration to advance Gulf Coast clean hydrogen projects

H-town

A handful of organizations have joined forces to create a new hub for the advancement of clean hydrogen projects in Texas, Southwest Louisiana, and the surrounding Gulf Coast region.

The HyVelocity Hub announced last week that it is applying for U.S. Department of Energy Regional Clean Hydrogen Hub funding. GTI Energy, The Center for Houston’s Future, The University of Texas at Austin, Air Liquide, and Chevron are among the founding members of the HyVelocity Hub.

“The name ‘HyVelocity’ conveys the idea that we have a tremendous opportunity to accelerate the creation of a clean hydrogen market at the pace needed to meet aggressive decarbonization goals for communities in our nation and around the globe,” says Paula A. Gant, president and CEO of Illinois GTI Energy, in a news release. “We need hydrogen deployment at scale, and this hub will lay the foundation with complete end-to-end demonstrations of an integrated network, match supply and demand regionally or locally, and leverage existing infrastructure to deliver resilient, reliable, and sustainable clean energy.”

The Gulf Coast is already a leader in hydrogen production, per the release, and the region is home to a diverse array of energy resources, including hydrogen production facilities and pipelines, a large base of industrial energy consumers, and a skilled, technical workforce.

“We are pleased to be partnering with our colleagues at GTI Energy in creating HyVelocity Hub as the implementation platform for the shared vision of a Texas-sized global clean hydrogen ecosystem created by our collaborative stakeholder process," says Brett Perlman, CEO of The Center for Houston’s Future in the release. “The realization of this vision will be achieved faster with clean hydrogen hub funding under the Bipartisan Infrastructure Law.”

Earlier this year, the Center for Houston's Future released a report that outlined what it will take for Houston to establish itself as a hub for hydrogen innovation as well as the impact this industry can have on Houston's economy. The HyVelocity Hub will engage environmental and social justice organizations in the Gulf Coast region to grow the local economy and create jobs in disadvantaged communities, according to the release.

“Accelerating clean energy technologies is vital to addressing global climate challenges as well as local air quality, and Port Houston is excited to participate in advancing these efforts with the HyVelocity Hub,” says Rich Byrnes, chief infrastructure officer of Port Houston, in the release. “The Hub will benefit trucking and maritime sectors, and our communities tremendously with cleaner transportation, lower emissions, new jobs, and both social and environmental equity."

There's a lot of clean tech potential in hydrogen — and Houston might be the place to lead the way. Image via Getty Images

New report shows why now is the time for Houston to emerge as a hub for hydrogen innovation

clean energy

Houston, known for being the energy capital of the world, has potential to lead innovation within the hydrogen space, and a new report lays out how.

The report, which was released today by the Center for Houston’s Future, is titled "Houston as the epicenter of a global clean hydrogen hub." The information explains how Houston-based assets can be leveraged to lead a global clean hydrogen innovation.

“The Houston region has the talent, expertise and infrastructure needed to lead the global energy transition to a low-carbon world. Clean hydrogen, alongside carbon capture, use, and storage are among the key technology areas where Houston is set up to succeed and can be an example to other leading energy economies around the world,” says Bobby Tudor, chair of the Greater Houston Partnership’s Houston Energy Transition Initiative, in a news release.

Together, GHP's HETI and over 100 experts representing 70 companies and organizations produced the report, along with McKinsey and Company, which donated significant research and economic analyses. Here are some highlights from the study, according to the release:

Clean hydrogen production could grow 5 times over current hydrogen production by 2050.
The establishment of a clean hydrogen industry could create 180,000 jobs (direct, indirect and induced) statewide, while adding $100 billion to Texas' GDP growth.
Globally, a Houston-led clean hydrogen hub could abate 220 million tons (MT) tons of carbon emissions by 2050.

“This report gives additional weight to the already strong case that Houston is uniquely positioned to lead a transformational clean hydrogen hub with global impact,” says Houston Mayor Sylvester Turner. “We can also deliver economic growth, create jobs and cut emissions across Houston and the Gulf Coast, including in underserved communities.”

The Houston region already produces and consumes a third of the nation’s hydrogen, per the release, and has more than 50 percent of the country’s dedicated hydrogen pipelines. These assets can be utilized to accelerate a transition to clean hydrogen, and the report lays out how.

"Using this roadmap as a guide and with Houston’s energy sector at the lead, we are ready to create a new clean hydrogen economy that will help fight climate change as it creates jobs and economic growth,” says Center for Houston’s Future CEO Brett Perlman. “We are more than ready, able and willing to take on these goals, as our record of overwhelming success in energy innovation and new market development shows.”

Check out these conferences, pitch events, networking, and more happening in Houston in the month of April. Photo via Getty Images

10+ can't-miss Houston business and innovation events for April

where to be

After a very busy March, Houston innovators might need to prepare for another month of networking opportunities. Here's a rundown of what all to throw on your calendar for April.

This article will be updated as more business and tech events are announced.

April 5-6 — Energy CEO Summit

Industry leaders and members of the Houston business community will discuss the evolution of the energy sector, Houston's pivotal role, and the critical events driving the change.

Center for Houston's Future CEO Brett Perlman will moderate a panel on Electrical Grid Trends at 9:30 a.m. on Wednesday, April 6.

The event is Tuesday and Wednesday, April 5-6, online or at Asia Society Texas Center (1370 Southmore Blvd.). Click here to register.

April 6 — 2022 PVAMU Industry Innovation Collaboration Day

This event is designed to provide an interactive platform for academicians, researchers, students, industries, and government agencies an opportunity to meet and share recent innovations, developments, and technology trends. Collaboration between the university and various industries needs to be nourished to enhance innovation development for the benefit of society.

The event is Wednesday, April 6, from 8:30 am to 5 pm at Prairie View A&M University-MSC Ballroom (155 L.W Minor St.). Click here to register.

April 6 — Enventure "Inspire" Seminar Series - With Dr. Santosh A. Helekar, MD, PhD

The "Inspire" Seminar Series was developed by Enventure to help students learn about the reality of working in the biotech and biomedical fields. The series consists of a number of events starring guest speakers coming from different areas in the biotech and biomedical industries.

This particular event will star Dr. Santosh A. Helekar, M.D., Ph.D. Participants attending this event will learn about the story of Dr. Helekar and his experiences from transitioning from grad school & academia into an inventor & his experiences and current role. In addition, there will be a final Q&A where the audience will be able to ask direct questions to Dr. Helekar.

The online event is Wednesday, April 6, from 6 to 7:30 pm. Click here to register.

April 7 — Low-Carbon Hydrogen Accelerator Kickoff

Together with Greentown Labs and the Urban Future Lab, EPRI and Shell recognize the need to accelerate the development and commercialization of low-carbon technologies required to enable economy-wide decarbonization. As leaders in the utilities and energy industries, respectively, with domain expertise, R&D facilities, and access to global customers, EPRI and Shell are uniquely positioned to lead this transformation in partnership with startups innovating at the cutting edge of low-carbon hydrogen.

The hybrid event is Thursday, April 7, from 5:30 to 8 pm at Greentown Labs (4200 San Jacinto St.) and streaming online. Click here to register.

April 7-9 — 2022 Rice Business Plan Competition

The 2022 Rice Business Plan Competition will be hosted in Houston at the Jones Graduate School of Business. This year, 42 teams have been invited to compete in the 22nd Annual Competition. The finals will be streamed online —watch on Saturday, April 9 on our YouTube. If you're a member, please visit our membership page to register to attend in-person.

The competition is held Thursday through Saturday, April 7-9, at Rice University (6100 Main St.) and streamed online. Click here to register.

April 12 — Energy & Energy 2.0 Council

As the Energy Capital of the World, Houston is the headquarters and the intellectual capital for virtually every segment of the energy industry including exploration, production, transmission, marketing, supply, and technology. This Council explores how Houston's largest industry continues to lead in this critical sector while also advancing innovation that supports the transition to a more efficient and sustainable, low-carbon future that also accommodates global demand growth.

The event is Tuesday, April 12, from 11:30 am to 1 pm at Partnership Tower (701 Avenida de las Americas, Suite 900). Click here to register.

April 12 — Softeq Venture Studio Demo Day (Q1 2022 Cohort)

The Softeq Venture Studio invested $125,000 in cash and services in each of the nine early-stage startups to help them refine their business model, build their technology, and prepare them to scale. In this capstone event, founders have seven minutes each to present their pitch deck, demo their product, outline their ask, and answer questions. And we need you there to evaluate them for investment (or at least support them).

The event is Tuesday, April 12, from 5 to 7:30 pm at The Ion (4201 Main St.). Click here to register.

April 13 — Serving & Selling: Building your Brand, brought to you by Insperity

Find out how to solidify your brand, deliver exceptional service, and take your productivity to the next level, with Pete Hinojosa, CBPA.

The event is Wednesday, April 13, from 1:30 to 2:30 pm at The Cannon (1334 Brittmore Dr.). Click here to register.

April 14 — DivInc Happy Hour: Meet the Sports Tech Cohort

Meet DivInc's Sports Tech cohort at a happy hour hosted at The Ion on April 14. The companies accepted into the new cohort are slated to be announced on April 11.

The event is Thursday, April 14, at 5:30 pm at The Ion (4201 Main St.). Click here to register.

April 19 — State of Technology

The second annual Greater Houston Partnership event features business leaders discussing Houston's growth as a national leader in tech innovation and the many qualities the region possesses that support a robust tech ecosystem. Through a panel discussion, the event will also explore how Houston is uniquely enabling digital transformation across industries including energy, life sciences and healthcare, manufacturing, logistics, and aerospace.

The event is Tuesday, April 19, at 10 am to 1:30 pm at Hilton Americas (1600 Lamar St.). Click here to register.

April 20 — Spring 2022 D2K Showcase

Explore Rice University's D2K students’ end-of-semester projects covering a wide range of topics including computer vision, natural language processing, deep learning applications, web scraping, time series analysis, signal processing and more. Celebrate the impact they are making through data science and interact with Rice students and learn more about their projects in the poster session. Attendees can vote for their favorite project/team to compete for cash prizes.

The event is Wednesday, April 20, from 5 to 7 pm at Duncan Hall at Rice University (6100 Main St.). Click here to register.

April 20 — The H. Albert Napier Rice Launch Challenge Championships

Join Liu Idea Lab for Innovation and Entrepreneurship and support Rice University student startups at the H. Albert Napier Rice Launch Challenge Championships on Wednesday, April 20. Six student finalists will pitch their ventures for the chance to win a share of $75,000+ in equity-free funding. Attendance is open to Rice students, Rice alumni, friends of Rice, and the whole Houston entrepreneurial community. Seats are limited, so get your tickets while you still can.

The event is Wednesday, April 20, from 5:30 to 9 pm at The Anderson-Clarke Center’s Hudspeth Auditorium (6100 Main St.). Click here to register.

April 21 — Greentown Houston's First Anniversary

A year after opening the Houston's first-ever climatetech startup incubator, Greentown Houston is home to over 60 startup members and 20 corporate partners. Join the green tech hub for a celebration of entrepreneurship, collaboration, and innovation, which together with the engineering strength and talent of the region’s energy industry will power Houston’s climate leadership. The day of festivities will include celebratory remarks, lightning pitches from some of our outstanding startups, a member showcase, networking, and more.

The event is Thursday, April 21, from 1 to 7 pm, at Greentown Houston (4200 San Jacinto St.) or livestreaming online. Click here to register.

April 27 — Engage VC: Revolution

Revolution is a D.C.-based investment firm focused on investing in entrepreneurs building transformative companies outside of Silicon Valley. With $1.7 billion of capital commitments across portfolio companies including Houston-based Goodfair and relationships in 60+ startup communities, Revolution is dedicated to creating meaningful results for companies outside of the Bay Area. And they are coming to Houston. Join HX Venture Fund to hear Tige Savage, Co-Founder & Managing Partner at Revolution Ventures, David Hall, Managing Partner at Revolution's Rise of the Rest Seed Fund, and Martin Simoncic, President B2B at PROS discuss Revolution's perspective on venture investing, current and future trends, and how Houston fits in among other topics.

The event is Wednesday, April 27, at 8:30 to 10 am at The Ion (4201 Main St.). Click here to register.

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

2024 Google search volume for terms related to investing
Number of investors
Number of businesses receiving investments in 2024
Total amount of capital invested in businesses in 2024
Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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