Memorial Park, which is currently undergoing a master plan renovation, and other Houston parks can be a great opportunity for introducing urban conservation inside the city limits. Rendering courtesy of Nelson Byrd Woltz

The Houston toad is a species that was discovered in Harris County in the 1950s. It has a very distinct, loud call that reverberates at quite a high pitch. But the Houston toad's call hasn't been heard in the city of Houston for almost 50 years. The species is locally extinct and critically endangered elsewhere. In fact, it's the most endangered amphibian in North America, says Cassidy Brown Johnson, a Rice University lecturer and president of the Coastal Prairie Partnership.

"When we think about extinction, we think of the dodo bird or the woolly mammoth," Johnson says. "But extinction is happening right underneath our noses."

The Houston Zoo has a breeding facility for Houston toad, but other than that, it's extremely unlikely that the Houston toad will ever reside naturally in its namesake city.

"We have modified the environment so heavily, that it'd be a bit of a dicey thing to do [to reintroduce the species] because there are so few of them, it's better to focus on an environment where it's still OK for them," Johnson says. The largest population of the Houston toad is actually in Bastrop, however due to the Bastrop fires in 2011, the species is only just recently back to a good place even there.

Johnson is giving a free lecture in April at Rice regarding extinction, where she'll bring her Astros-named Houston toads, Springer and Julia Morales, as her teacher aids.

Changing tides in conservation
As cities like Houston continue to be developed, scientists and researchers are challenged with finding new ways to effect conservation. Johnson says within the industry, there's been a shift in thinking when it comes to preserving nature.

"There's a new burgeoning movement in conservation called urban conservation," she says. "For a long time, if you talked to the traditional conservationists, the idea of conservation is to protect big spaces — the national and state park systems are the perfect example."

But large parks are expensive and a huge undertaking. It's still the strongest form of conservation, but introducing conservation efforts in a city — perhaps in some of Houston's parks, like Memorial Park or Hermann Park — helps not only the species of animals involved, but also educates the local population and forms a connection with residents.

"That has a twofold kind of benefit," Johnson says. "It protects the greenspace so species to live with us, and then also it makes the connection to this place we try to protect."

Of course, this type of effort is new, and there's not a lot of data to show how this would affect the ecosystem and its species, from the migratory and genetic diversity standpoints. Despite the lack of data, Johnson says this type of effort needs to happen.

"We're going to continue to manipulate the world, and maybe if we started thinking about this now, that we can get to a point were we understand enough were we can make these some sort of functioning ecosystem," she says.

Part of the shift in thinking about these ecosystems has to do with new ways of tracking species and understanding their environments.

"Technology is helping us ask a lot of these questions," Johnson says. "Ecology is surprisingly complicated. There's so many variables. ... I think technology and our advance with computing is definitely going to help us understand it."

Using preservation to solve flooding
The educational component is also very important to conservation, and Johnson is making strides on campus with her class. Last year, her department and her class introduced a pocket prairie right on the Rice campus.

Before it was the fourth largest city in America, Houston was a prairie. That type of ecosystem — thick with prairie grass — is very absorbing when it comes to rain water.

"It's really surprising to people that the trees and all this lushness is actually all artificial," Johnson says. "We know that this ecosystem evolved with the cyclical flooding events that happened here."

This movement to bring back Houston's ancient ecosystem is a new focus on a few prairie conservationist groups — and even the Harris County Flood Control. This has been going on for a while, but recent flooding events have opened the eyes of people now looking for reliable solutions to flooding problems.

"After Hurricane Harvey, people started realizing that this might be one of the solutions we could actually investigate and see if it can help us," Johnson says. "A green space is going to absorb way more water than a parking lot."

Of course, there are other flood solutions being discussed — some even incorporating tech or even a tube system underground.

"Historically, there has been some budding of heads between the environment and technology, but I really think moving forward, those two fields have to work together. We need to use technology to save the environment," Johnson says. "I think Houston is one of the places where that conversation is starting to happen."

Missing the toads

Courtesy of Cassidy Brown Johnson

The Houston toad has been locally extinct since the 1970s.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.