The city tapped key partners for the initiative, including a Houston startup. Photo courtesy

City officials and business leaders in Houston are recruiting employers to collectively offer at least 12,000 paid jobs and internships this summer for local 16- to 24-year-olds.

Organizers on March 8 kicked off this year’s Hire Houston Youth initiative. It encourages employers in the public, private, and philanthropic sectors to bring aboard youth for summertime jobs and internships.

One of the program's partner is Ampersand, a Houston-based startup and tech platform that has designed a career-readiness curriculum for this age group. In partnership with the City of Houston, Ampersand customized a portion of its curriculum to upskill and prepare young Houstonians for the workforce across 35 lessons, five modules, and four hours of content — all of which provide essential job skills ranging from email best practices to mental health management in the workplace.

Employers can sign up for Hire Houston Youth online. The deadline for youth to apply for jobs or internships through this program has been extended from March 11 to April 8.

“Employment plays a pivotal role in reducing gender, ethnic, racial, and other social inequalities,” Mayor Sylvester Turner says in a news release. “Therefore, providing meaningful employment experiences for our youth is in the best interest of all, including young people, their communities, and Houston as a whole.”

In 2021, as the city coped with the height of the COVID-19 pandemic, Hire Houston Youth offered more than 9,500 opportunities. This year, Turner hopes the program can produce at least 12,000 jobs and internships, and as many as 15,000.

The National League of Cities recently awarded a $150,000 grant to Hire Houston Youth. In addition to the grant, Houston will receive assistance from National League of Cities staff and other experts to advance the city’s efforts to expand STEM career opportunities for marginalized young people.

The unemployment rate for 16- to 24-year-olds in the U.S. ranks as the highest among all age groups. In the pre-pandemic year of 2019, the national unemployment rate for the 16 to 24 age group stood at 8.4 percent. No other age group had an unemployment rate above 4.1 percent in 2019.

The jobless rate for people of color and lower-income people in this age group has historically been higher than the overall rate for that age group.

The pandemic exacerbated unemployment woes for 16- to 24-year-olds in the Houston area around the country. Data compiled by the Schultz Family Foundation and Mathematica shows that during the peak of the pandemic, youth unemployment rates in the Houston area ranged between a low of 12.6 percent from July to December 2020 and a high of 16.1 percent from January to June 2021.

The Measure of America project estimates that more than 4.1 million Americans in the 16-24 group are neither working nor attending school. In Harris County, 13.4 percent of 16- to 24-year-olds in Harris County met that definition in 2017, according to the Federal Reserve Bank of Dallas.

“The years 16-24 are crucial for the development of human capital — through activities such as education and workforce preparation that pay dividends in the form of higher wages, lower unemployment, and other benefits later in life. Yet even before the pandemic, many young people were disconnected from school and work and the economic opportunities that follow,” the Federal Reserve Bank of Dallas says in a 2021 report.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.