These three health tech startups are moving on in TMCi's accelerator program. Photo courtesy of TMC

Thee Texas Medical Center named three companies to its accelerator program. The health tech startups will join the program and make key connections to grow their technology and business.

Texas Medical Center Innovation announced this year's cohort for the TMC Innovation Accelerator for HealthTech. The companies attended TMCi's boot camp earlier this year before being named to the cohort.

“It is always exciting to introduce a new group of talented entrepreneurs into our community,” says Tom Luby, director of TMC Innovation, in a news release. “Each with their own goals, and at their individual stage, we’ll work closely together to help them learn, grow and navigate this rich clinical landscape. We are honored to be the bridge between these innovators and the world’s largest medical city.”

The selected startups include Oxford, United Kingdom-based CardMedic, which joins the program by way of TMC's UK BioBridge, an international partnership established to bring cutting-edge health tech startups to the United States by way of Houston. The company's technology is a digital "One Stop Communication Shop" — an extensive library of pre-written scripts that help staff and patients communicate across any barrier, including language, deafness, cognitive impairment, or disability.

“The opportunity to connect with Texas Medical Center member institutions, understand their problem domain, and in what ways that may differ from the United Kingdom is invaluable. We are really excited about learning from the expert team of strategic advisors at the TMCi Accelerator about areas we needed to focus on to grow our company in the United States,” says Rachael Grimaldi, co-founder and CEO of CardMedic.

Chicago-based CareAdvisors, which helps hospitals and clinical social workers connect patients to the best resources and benefits to address social care needs, also joins the TMCi accelerator. The company's technology, the Social Care Automation tool, enables hospitals to generate revenue from preventive health programs and helps health plans reduce overutilization by putting the focus on preventive care.

Roboligent, based in Austin, designs and manufactures robotic and automated physical therapy exercises for patients with upper and lowers limb musculoskeletal issues. This robotic-assisted rehab help promotes recovery while increasing rehab centers’ operational efficiency.

“Introducing a new and innovative product, especially in the medical device field, is a thorough and collaborative effort,” says Bongsu Kim, founder and CEO of Roboligent, in a news release. “TMC’s HealthTech Accelerator is the perfect place to make connections with experts and stakeholders to help guide us in reaching our next milestone.”

Texas Medical Center Innovation announced the seven health tech startups that joined the 2022 accelerator bootcamp. Photo courtesy of TMC

7 health tech startups flock to Houston for TMC bootcamp

ready to accelerate

The Texas Medical Center's innovation arm welcomed seven companies to its 2022 health tech accelerator program bootcamp.

TMC Innovation Accelerator for HealthTech is aimed at supporting early-stage life science startups through fundraising, connecting with mentors and potential customers, and more.

“Healthtech startups who connect with our network will emerge more prepared to access their customers and grow into their markets," says Emily Reiser, associate director of TMC Innovation, in a news release. "Our advisors, members, and partners unlock insights for these entrepreneurs about how to more effectively build a strategic plan for improved market access and adoption. Bootcamp ignites these connections, providing immediate value to entrepreneurs and enabling our team to define a long term plan for continued collaboration."

If selected following the bootcamp, founders will spend six months at TMCi with strategic mentorship, clinical validation, and other customized milestone development from the organization.

“Bootcamp is an intensive period of discovery and mutual selection," says Devin Dunn, head of the Accelerator for HealthTech, in the release. "Founders get a chance better understand everything that TMCi brings to bear and our team has the opportunity to select those growing companies that will add significant value to our community.”

The bootcamp focused on several innovation areas — including surgical devices, access to care, robotics, and hospital efficiency. The participating companies include:

  • CardMedic, headquartered in Oxford, United Kingdom, aims to improve communication between staff and patients across any barrier-language, deafness, cognitive impairment or disability-with an A to Z library of pre-written scripts replicating common clinical conversations.
  • Chicago-baseed CareAdvisors is connecting health plans, hospitals, and community-based organizations to streamline high risk case management and quickly close the loop on care.
  • Endolumik, founded in Morgantown, West Virginia, has developed a fluorescence-guided device that uses near-infrared light to enhance visualization for safer, faster, and more consistent bariatric surgery.
  • Orcha, based in Daresbury, United Kingdom, rigorously reviews apps to help systems, clinicians, patients, or consumers find their way to the best health-related apps.
  • Austin-based Roboligent has created a rehabilitation robot, the Optimo Regen, that provides evidence-based therapeutic interventions for upper and lower limbs.
  • Boston-founded ScienceIO's platform transforms unstructured text into structured records in real-time. The company's core product is a HIPAA-compliant API for real-time text processing and analytics.
  • Semantic Health, founded in Toronto, Canada, uses artificial intelligence to complete secondary reviews of all coded and claims data to optimize revenue cycle management.
The application for future cohorts and more information about the program are available online. The 2022 cohort will join the ranks of TMCi's community of 305 life science startups and 221 TMC Innovation Accelerator companies and will receive access to the center's dozens of member organizations.

"Having a product that the market truly needs is critical but not enough," says Bongsu Kim, founder and CEO of Roboligent, in the release. "Especially for the medical device market, I realize that introducing a new product is a thorough and collaborative effort from a variety of stakeholders and experts. Without knowing the mechanism and the right connection, it seems almost impossible to get into the market. The TMC Innovation Accelerator is the perfect place to make it happen."

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Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”

Houston startup raises $6M to scale home-based healthcare platform

fresh funding

As healthcare systems race to expand care beyond hospitals and into the home, investors are placing bigger bets on the infrastructure needed to make that shift possible.

This month, Rosarium Health announced it has raised $6 million in seed funding led by Kalos Ventures, with participation from ResilienceVC, Rock Health Capital, Symphonic Capital, Black Tech Nations Ventures and others.

The investment will help the Houston-based startup continue to build its platform, which features a national network of 800-plus clinicians and 3,000-plus contractors to coordinate home accessibility upgrades and modifications for seniors and people living with disabilities.

For founder and CEO Cameron Carter, the company’s mission grew out of firsthand caregiving experiences.

“From my own personal caregiving experiences, I realized that the benefits exist on paper, but not in reality,” Carter said in a news release. “Families are being left to figure out the paperwork and installations all on their own, which shouldn’t be how this works.”

While Medicare Advantage and Medicaid plans have expanded coverage for home-based services and accessibility modifications, the logistics behind delivering those services often remain fragmented.

Rosarium’s platform coordinates the entire process, from clinical assessments and referrals to contractor management, documentation, reimbursement and installation.

“A clinician can document that a home isn’t safe and a plan can approve a benefit, but there’s no one that’s responsible for making sure the work actually gets done,” Carter says. “We built the missing piece.”

The company was founded in 2021 as Rose Health and was a 2023 participant in the Texas Medical Center’s Accelerator for HealthTech program. It has scaled quickly, building a network of more than 800 clinicians and 3,000 contractors across 34 states.

Rosarium is currently in-network for 1.2 million Medicare and Medicaid lives, with projected coverage expected to reach nearly 4 million by the end of the year, according to the release.

“We’re excited to back Cameron because he and the team at Rosarium are building the infrastructure healthcare needs right now to make the home a safe and comfortable place of care,” Kate Ballinger, investor at Kalos Ventures, added in the release.

As part of the recent investment, Ballinger will join Rosarium’s board of directors.

With eyes on the future, Rosarium plans to grow its partnerships with Medicaid and Medicare Advantage plans, including CalViva and Community Health Plan of Imperial Valley, strengthening its presence in California while expanding access to underserved communities.

Additionally, Carter predicts that home-based healthcare will be part of a broader transformation happening across the industry.

“There’s a growing recognition that health outcomes are shaped by what happens in the home,” he said in the release. “The future of healthcare isn’t just treating people after something goes wrong. It’s creating environments that help prevent those problems in the first place.”