Exclusive: Canadian energy software company plans to grow local team and open Houston office

new to Hou

A Canadian software company is expanding its presence in Houston to meet the needs of its clients. Photo via Getty Images

One of the biggest obstacles heavy industry tech startups face — especially in oil and gas — is getting that first big customer, says Vicki Knott, co-founder and CEO of Crux OCM.

"Our biggest challenge is nobody wants to be first in energy," she tells InnovationMap.

But Crux OCM, based in Calgary, overcame that challenge and currently counts Houston-based Phillips 66 among its clients. The two companies announced a pilot program for Crux OCM's pipeBOT technology earlier this year.

Crux OCM's technology focuses on automating the control room operations — something that, like most automation software, increases revenue and reduces errors. The company, which was founded in 2017, also allows its clients consistency and reliability with its software.

"Even though the pumps and the equipment are automated, control room operators are still executing procedures, checklist, and rules of thumb on their own via screens," Knott says. "If you think of pilots and planes have autopilot software, why don't our control room operators? That's really the problem we set out to tackle."

Vicki Knott is co-founder and CEO of Crux OCM. Photo courtesy

Automation is certainly a growing opportunity for energy companies — especially in light of the pandemic that forced remote work and less on-site personnel across industries. Knott says just over a year ago, Crux OCM saw increased interest.

"We had a couple customers who had their capital budget cut when the pandemic hit and when oil went negative, and we had a couple customers who said they were doubling down on software like this," Knott explains.

The company has raised $3 million in venture funding, backed by Root Ventures, Angular Ventures, and Golden Ventures. Knott says another funding round is on the horizon as is growth for its Houston presence.

Crux OCM currently has three full-time Houston employees and is looking to grow that team in the next six months. Specifically, the local team will focus on sales, as well as product development, as the company's head of sales and senior product manager are both based here. As the local clientbase grows, Knott says they will also need to hire deployment engineers as well.

A new office to support this growing team is also in the works. Knott says she's looking for space in North Houston, and, depending on how comfortable people are returning to offices and meetings, it could open as early as later this year.

Calgary and Houston have a lot in common, Knott says, and she sees a very natural connection to the two regions. Knott plans to work six months of the year in Houston with the local office.

"A lot of the companies that head offices in Houston, they have head offices in Calgary," she says. "If a startup in Houston is getting traction, I think there's a natural movement to start in the Calgary market and vice versa."

Catch up on space news — from new partnerships at Rice University and the latest snub for the Space City. Photo via NASA.gov

Space City News: Houston passed over for military HQ, Rice forms new partnerships

aerospace updates

It's been a busy few days for space news, and in Houston — the Space City — it's all relevant to the continued conversation of technology and innovation.

With so much going on — from Houston being passed over for the Space Command's headquarters and Rice receiving $1.4 million in federal funds for a new hub — here's what you may have missed in space news.

The Ion awarded $1.4M to launch Aerospace Innovation Hub

The Ion will be home to the Aerospace Innovation Hub, thanks to a federal grant. Courtesy of Rice University

Through a partnership with NASA's Johnson Space Center and DivInc, The Ion has been awarded $1.4 million in federal funding to create its Aerospace Innovation Hub. The ASCI-Hub will support and develop regional minority business enterprises addressing aerospace-related challenges.

"Landing this award is another win for the region that leverages the unique strengths of the crewed space program at NASA JSC," says Jan E. Odegard, interim executive director of the Ion, says in a news release. "As Houston was critical to landing men on the moon in the late-'60s, the Ion's Aerospace Innovation Hub will be key not only to advancing the future of spaceflight, including the mission to Mars in the future, but also to tackling challenges facing our everyday lives here on Earth."

The hub will provide NASA's expertise and resources across robotics, medicine, health support systems, additive manufacturing, and more — as well as community events, education and training, and an accelerator program.

"We're eager to partner with the MDBA, Rice University and the Ion to help develop and grow minority entrepreneurs and accelerate innovative and tech-forward solutions in Houston," says Vanessa Wyche, deputy director of the JSC, in the release. "This partnership builds toward NASA's goals to enhance scientific and technological knowledge to benefit all of humankind and catalyze economic growth, as we propel commercialization of space and extend our presence in the solar system."

Opening in 2021, the Ion announced $1.5 million in grant funds in September. Those funds are going toward accelerators, which will collaborate with the Aerospace Innovation Hub.

"While we have taken many small — and valuable — steps over the past few years, this is one giant leap forward for our efforts to promote sustainable inclusion in Houston's entrepreneurial and technological ecosystem," says Christine Galib, senior director of programs at the Ion, in the release.

The Air Force announces 6 potential sites for Space Force base — and Houston misses the mark

Houston will not be considered for the Space Command HQ — but Texas isn't completely out of the running. U.S. Air Force Graphic by Rosario "Charo" Gutierrez

The United States Department of the Air Force announced the six candidate locations for the U.S. Space Command Headquarters — and Houston didn't make the cut.

The six locations include:

Kirtland Air Force Base in New Mexico
Offutt AFB in Nebraska
Patrick AFB in Florida
Peterson AFB in Colorado (where temporary operations are located)
Port San Antonio in Texas
Redstone Army Airfield in Alabama

The Air Force evaluated self-nominated cities from across 24 states based on factors related to mission, infrastructure capacity, community support, and costs to the Department of Defense, according to a press release. U.S. Space Command Headquarters location announcement is expected in early 2021.

"We are disappointed that Houston is not among the finalist locations for the U.S. Space Command," Susan Davenport, chief economic development officer for the Greater Houston Partnership, says in a statement to the Houston Chronicle. "We believe we put together a strong case for why Houston should be chosen. We will continue to work with the U.S. Air Force and other branches of the military on future opportunities and we will remain vigilant in our pursuit of aerospace industry opportunities for this region."

Rice Space Institute to collaborate with Canada

The Rice Space Institute has a new partner is Canada. Photo courtesy of NASA

Rice University's Rice Space Institute has signed a memorandum of understanding with the Consulate General of Canada in Dallas to collaborate on space science and technology.

The parties made the collaboration official at a virtual event on November 20. RSI Director David Alexander OBE, a Rice professor of physics and astronomy, says the partnership is key to the continued commercialization of space exploration.

"What's different about this agreement is that with the rapid growth of commercial space worldwide and the strength of the aerospace industry in Houston, it presents a new pathway for potential interactions between Canadian science and industry and commercial entities not just in the Houston region but around the world," he says in a news release. "It's a nice, complementary aspect to our connection with NASA."

The United States has collaborated with Canada on space exploration for decades, and Canada's government is committed to advancing space technology.

"This MOU with the Rice Space Institute comes at an exciting time in human space exploration," says Rachel McCormick, the Consul General of Canada in Dallas and Canada's official representative in the U.S. South Central region, in the release. "In 2019, the Government of Canada announced an investment of $1.9 billion over 24 years for the next generation of smart, AI-powered space robotics for the U.S.-led Lunar Gateway program.

"We are also providing $150 million over five years for the Lunar Exploration Accelerator Program," she continues. "LEAP will fund the development and demonstration of lunar science and technologies in fields that include AI, robotics and health."

Validere, a Canada-based energy logistics company, is expanding in Houston. Courtesy of Validere

Canadian startup fresh off $7 million seed funding raise picks Houston for U.S. expansion

Energy Tech

Houston's established reputation as the energy capital of the world combined with burgeoning tech scene has made the city attractive for a growing oil and gas company with roots in Canada.

Validere is an oil and gas company focused on using real-time data and both artificial and human intelligence insights to improve its clients' quality, trading, and logistics. The company's technology enhances the ability of oil and gas traders to make informed decisions, which currently are made based off unreliable product quality data. Annually, $2 trillion of product moves around the oil and gas industry, and Validere uses the Internet of Things to improve the current standard of decision making.

"It's like if you'd go to the grocery store to buy milk not knowing if it's 1 percent, 2 percent, or cream," co-founder Nouman Ahmad says about how companies are currently making oil and gas trading decisions.

In October, Validere concluded its seed funding round with $7 million. Among Validere supporters are several Silicon Valley power players, such as Sallyport Investments, Y Combinator, Real Ventures, Moment Ventures, and ZhenFund. The funds, in part, will help the company expand into the United States market.

"The goal in 2019 is to be at the same stage — in terms of customer success — in the U.S. market as we were at the end of 2018 in the Canadian market," Ahmad says.

The company has seen great success in Canada, and some of its existing clients have business in the Houston area already, Ahmad says.

With the increased focus on Houston comes a growing office. Currently, Ahmad leads the efforts in town with one other staffer, however, operations won't be a skeleton crew for too much longer. Ahmad says he is "aggressively hiring" in the Bayou City, which will be a key office for them as they grow across the country.

"As we think about the long-term future of the business, Houston is one of the most important markets for us going forward," Ahmad says.

Houston has been a welcoming community to the Canadian transplant, who says he spends most of his time here now. Both the startup and tech scenes in Houston have been valuable resources to the company — as has the energy industry's potential clients.

"Houston market is very receptive and ready for innovative companies that are solving problems for them," Ahmad says.

The company was founded in 2015 at Harvard by entrepreneurs who saw the potential for better transparency in the oil and gas industry. Validere's other co-founder and CTO, Ian Burgess, first had the idea for the technology after an accident happened in Canada; a train carrying crude oil derailed and blew up a small town killing 45 people.

"The industry largely bases important operational decisions on poor quality data," Burgess says in a release. "Our platform not only informs product quality reliably and in real time, but it also uses AI to help oil and gas companies optimize product movement."

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

$1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
$922 million for the University of Houston System
$167 million for Texas Southern University
$10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
Created the Lake Houston Dredging and Maintenance District
Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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