Cadence is investing in Girlstart, an Texas-based nonprofit empowering women in STEM. Photo by Amber Heckler

This week, the worlds of the Lone Star State's tech scene, women in STEM, and Formula 1 collided.

At a private event on Wednesday, October 19, hosted by computational software company Cadence Design Systems, Senior VP of Global HR Tina Jones spoke highly about the pride she felt about Cadence’s company culture and their goals for leaving the world better than they found it in regards to sustainability and giving back to the community. Last week, Cadence was ranked 19th in the 2022 World’s Best Workplaces list.

One of the ways Cadence is giving back to the community is through their Giving Foundation. The foundation is investing in organizations like Girlstart, an Austin-based nonprofit whose mission is to empower young girls’ interest in STEM through educational programs and camps.

“We are determined to make a difference in access to STEM education for those who have been traditionally underrepresented,” Jones said.

Jones announced Cadence would make a $25,000 donation to Girlstart to help further the organization’s mission and to invest in the future women they want to hire. The organization has locations all around Texas, including Dallas, Houston, San Antonio and the Rio Grande Valley, as well as locations in other states like California, Illinois, Washington, and Massachusetts.

“We want to start at Kindergarten and take them through 12th grade and give girls confidence in STEM,” Jones said, “Girlstart is doing that here in Austin, and we’re super proud to be associated with them.”

Girlstart Executive Director Shane Woods was present to accept the donation. During her speech, Woods discussed the importance of broadening young women’s understanding of what STEM is and nurturing a positive mentality so they can stay inspired in their careers.

Part of Woods’ work is to make sure girls know about the different fields that “need STEM eyes” such as biomedical engineering, environmental sustainability, and social justice.

The rest of the event centered around Cadence’s partnership with F1 team McLaren Racing, with three primary team members in attendance – CEO Zak Brown, Team Principal Andreas Seidl, and driver Daniel Ricciardo.

Ricciardo has never been shy about his love for the capital of Texas. He said he was naive about the city when F1 first arrived in 2012, but now it’s one of his favorite places. Circuit of the Americas is one of his favorite challenging tracks, noting the “high speed snake section” at turns three through eight that remind him of similar turns Maggotts and Becketts at Silverstone.

“A circuit that really pushes the car to the limits is fun,” he said, “That’s what I love about Austin.”

McLaren’s partnership with Cadence is significant for more than their expertise with computational fluid dynamics. Both companies share similar goals in regards to environmental sustainability and equality. In 2021, McLaren became the first F1 team to release an annual sustainability report, showing they are on track to achieve carbon net zero by 2040. In that same year, they announced Emma Gilmour would be the team’s first female racing driver, racing in Extreme E alongside Tanner Foust.

When asked about what they predict the next 10 years of Formula 1 will look like, Brown and Ricciardo agreed they hoped to see F1 still thriving and at the pinnacle of motorsport, while also giving recognition to the rise of other motorsports. Brown said he would like to see the introduction of rotational races in other countries.

“We have a lot of countries that want races. We’re at a maximum schedule of 24…I would love to see us in 30 countries, but 24 times a year. You might land on 18 permanent races and then have 10 that rotate every two years or something like that,” Brown said. “I think there’s room to grow the sport globally."

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This article originally ran on CultureMap.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."