Houston's startups and small businesses have a ways to go to truly survive the pandemic, and they should move forward with these things in mind. Emilija Manevska/Getty Images

The effect of COVID-19 on Houston's economy has been unprecedented. While evidence on this impact is only beginning to emerge, it is clear that the economic damage has been particularly severe for startups and small and growing businesses in emerging markets.

Given the importance of startups and small businesses to economic growth and job creation, the survival of these businesses must be a critical part of the global recovery. For example, there are many companies that have seen this pandemic as an opportunity and started providing COVID-19-related services.

Startups are facing financial challenges on multiple fronts

According to a study from Houston Exponential's:

  • Thirty percent of startups reported a loss of revenue due to client uncertainty or delayed contracts. With almost 85 percent of startups identifying as B2B or B2C, many companies are seeing previously guaranteed revenues shrink as enterprise clients cut costs.
  • Twenty-one percent of startups reported paying talent as their biggest talent/hiring challenge. The main concern isn't with finding qualified candidates, it's being able to pay for them. Founders stated that the talent exists, but they can't afford them, or candidates aren't willing to accept a lower salary for equity.
  • Nineteen percent of startups reported a 10 to 20 percent decrease in fundraising valuations. This statistic only includes startups that were raising before and during COVID-19. And 71 percent reported no change in valuations.
  • Fourteen percent of startups reported moving to remote work as their biggest operational challenge. This includes both internal challenges as well as working with clients and prospective customers remotely.

How startups have been using funding amid COVID-19

Post $1 million in funding, the hiring focus shifts to product development.

  • Companies that have raised less than $1 million are looking to drive growth, find sources of revenue and improve their top-line metrics through biz dev, marketing, and sales.
  • Companies that have raised more than $1 million are focusing more on building out and improving their product by hiring engineers and product managers

Note: The median seed round for Houston startups over the past 3 years was $1.9 million and the median angel deal was $610,000, according to Pitchbook.

Tips for surviving the pandemic

The Small Business Continuity Checklist is a diagnostic tool to navigate times of disruption, covering two key areas of management — financial and strategic.

Financial Management Tasks

  • Address future cash shortages, for example, what expenses could be reduced, such as travel and marketing, which operations can be temporarily paused.
  • Consider steps to increase cash coming into the business such as focusing more on product lines/ services that continue to sell well.
  • Explore what grants, subsidies, or loans are available and the eligibility requirements. For example, The Cannon's CERT Program. Here's a list of resources for Houston startups and SMBs.
  • Recycle, re-purpose, or dispose of old or slow-moving stock or inventory. Explore the possibility of sales under special conditions, in order to reduce the projected losses on inventories. Review purchasing policies to prevent overspending on stock/inventory.

Strategic Management Tasks

  • Since user retention is crucial for your future growth, you can provide free subscriptions, contactless delivery, and waive fees to address a larger user base and enhance customer experience. For example, many online learning sites are providing free access to their live and video classes. Similarly, in the healthcare and fitness space, companies can provide for free virtual classes and shift to providing online consultations. Cure.Fit, fitness startup has provided free access to their live classes for 90 days. All hyperlocal delivery companies have rolled out 'contactless delivery' to minimize any contact between the customer and the delivery executive. They have also urged customers to adopt 'digital payments' to again minimize any human contact.
  • Nowadays, most startups and SMBs rely on different kinds of software, web apps, and/or mobile apps. Furthermore, many businesses are dependent on such digital platforms. If you are developing any digital solution then you should consider outsourcing some part of development/design work to app development in Houston to reduce the cost. You can find more local options from sites like Clutch or Upcity.
  • Ensure productivity while working remotely. While fostering collaboration has long been a defined way of working in most modern businesses, proximity is a variable that has always been taken for granted. Don't just limit to video conferencing, also invest in project management tools, time tracking tools, communication tools etc.
  • Build trust, support staff, and understand emotional concerns and the importance of personal well being.

Startups are the engines of progress. Small businesses are the backbone of America. Stay safe. Stay healthy. And keep persevering. No matter how severe and disruptive this crisis is, one thing is for sure, the war on this pandemic will be won.

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Colin Simpson is project manager at BlueKite Apps, which recently started its software development services in Houston.

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Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.

New accelerator for AI startups to launch at Houston's Ion this spring

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform.

The AI Native Dual-Use Sports, Health & Wellness Accelerator, scheduled to formally launch in March, will back early-stage startups developing AI for the sports, health and wellness markets. Accelerator participants will gain access to a host of opportunities with:

  • Mentors
  • Advisers
  • Pro sports teams and leagues
  • University athletics programs
  • Health care systems
  • Corporate partners
  • VC firms
  • Pilot projects
  • University-based entrepreneurship and business initiatives

Accelerator participants will focus on sports tech verticals inlcuding performance and health, fan experience and media platforms, data and analytics, and infrastructure.

“Houston is quickly becoming one of the most important innovation hubs at the intersection of sports, health, and AI,” Ashley DeWalt, co-founder and managing partner of The Collectiv and founder of The Collectiv Foundation, said in a news release.

“By launching this platform with Rice University in the Ion District,” he added, “we are building a category-defining acceleration engine that gives founders access to world-class research, global sports properties, hospital systems, and venture capital. This is about turning sports-validated technology into globally scalable companies at a moment when the world’s attention is converging on Houston ahead of the 2026 World Cup.”

The Collectiv accelerator will draw on expertise from organizations such as the Rice-Houston Methodist Center for Human Performance, Rice Brain Institute, Rice Gateway Project and the Texas Medical Center.

“The combination of Rice University’s research leadership, Houston’s unmatched health ecosystem, and The Collectiv’s operator-driven investment platform creates a powerful acceleration engine,” Blair Garrou, co-founder and managing partner of the Mercury Fund VC firm and a senior adviser for The Collectiv, added in the release.

Additional details on programming, partners and application timelines are expected to be announced in the coming weeks.

4 Houston-area schools excel with best online degree programs in U.S.

Top of the Class

Four Houston-area universities have earned well-deserved recognition in U.S. News & World Report's just-released rankings of the Best Online Programs for 2026.

The annual rankings offer insight into the best American universities for students seeking a flexible and affordable way to attain a higher education. In the 2026 edition, U.S. News analyzed nearly 1,850 online programs for bachelor's degrees and seven master's degree disciplines: MBA, business (non-MBA), criminal justice, education, engineering, information technology, and nursing.

Many of these local schools are also high achievers in U.S. News' separate rankings of the best grad schools.

Rice University tied with Texas A&M University in College Station for the No. 3 best online master's in information technology program in the U.S., and its online MBA program ranked No. 21 nationally.

The online master's in nursing program at The University of Texas Medical Branch in Galveston was the highest performing master's nursing degree in Texas, and it ranked No. 19 nationally.

Three different programs at The University of Houston were ranked among the top 100 nationwide:
  • No. 18 – Best online master's in education
  • No. 59 – Best online master's in business (non-MBA)
  • No. 89 – Best online bachelor's program
The University of Houston's Clear Lake campus ranked No. 65 nationally for its online master's in education program.

"Online education continues to be a vital path for professionals, parents, and service members seeking to advance their careers and broaden their knowledge with necessary flexibility," said U.S. News education managing editor LaMont Jones in a press release. "The 2026 Best Online Programs rankings are an essential tool for prospective students, providing rigorous, independent analysis to help them choose a high-quality program that aligns with their personal and professional goals."

A little farther outside Houston, two more universities – Sam Houston State University in Huntsville and Texas A&M University in College Station – stood out for their online degree programs.

Sam Houston State University

  • No. 5 – Best online master's in criminal justice
  • No. 30 – Best online master's in information technology
  • No. 36 – Best online master's in education
  • No. 77 – Best online bachelor's program
  • No. 96 – Best online master's in business (non-MBA)
Texas A&M University
  • No. 3 – Best online master's in information technology (tied with Rice)
  • No. 3 – Best online master's in business (non-MBA)
  • No. 8 – Best online master's in education
  • No. 9 – Best online master's in engineering
  • No. 11 – Best online bachelor's program
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This article originally appeared on CultureMap.com.