Houston First Corp. will sponsor the Aira technology at several venues across the city so that the blind and vision impaired can enjoy each area. Photo by Micahl Wycoff

A partnership between the Houston First Corporation and Aira, an app that helps blind and low-vision people gain independence by navigating tasks and public spaces, is now live at venues around the city.

Houston First will cover the costs of use for the app in its venues, including the George R. Brown Convention Center, Avenida Houston, Wortham Theater Center, and Jesse H. Jones Hall for the Performing Arts. The organization has plans to expand to the Miller Outdoor Theatre, said John Gonzalez, senior vice president of operations and general manager for Houston First.

"Technology is changing the experiences users have at our events," Gonzalez said. "We want to make our venues as accessible as possible."

California-based Aira's role in offering a vessel for facilities to be more accessible to low-vision and blind Houstonians is groundbreaking, said Vince Morvillo, an account executive with Aira who is blind.

"This technology is as important to a blind person as it is to a sighted person," Morvillo said. "You, as a person with sight, have the opportunity to look, to see things, to interact with people. When you're blind, you're not out and about; you don't have too many people to interact with. The ability to be able to go and do something when you choose to do so is really important."

The app essentially creates sight on demand. Users can use the Aira app on their smartphones and be connected to a trained operator, who will help them navigate the scene around them using video being fed to the app through their phone. The operators will then guide the user to their destination or even help them with everyday necessities like grocery shopping.

"The blind world needs this," Morvillo said. "This technology gets blind people out in the world. Businesses know how successful they are by how many people support them. I just don't understand why blind people are an untapped resource. Nobody's out there trying to get the blind shopper."

In addition to the blind population, Morvillo says that this will also help the aging population, who may often struggle with their vision later in life, and will increase accessibility options around the city.

Aira and Houston First's efforts to increase accessibility for patrons are now being recognized nationally. The National Federation of the Blind recently announced it would be bringing its annual convention to Houston in 2020.

"We are thrilled to host the group and are committed to providing a safe and enjoyable experience for all visitors," Houston First said in an email to InnovationMap. "It is our goal that Houston First venues provide an entertaining and immersive experience for all guests, and our partnership with Aira puts us one step closer to achieving that goal."

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.