Clinical-stage Houston cell therapy company closes $28.4M oversubscribed series A

cha-ching

March Biosciences' oversubscribed raise brought in $28.4 million of financing with Mission BioCapital and 4BIO Capital leading the pack of investors. Photo via Getty Images

An emerging biotech company in Houston has closed its series A with outsized success.

March Biosciences' oversubscribed raise brought in $28.4 million of financing with Mission BioCapital and 4BIO Capital leading the pack of investors. The company has now raised more than $51 million in total.

Last year, March Biosciences announced its strategic alliance with CTMC (Cell Therapy Manufacturing Center), a joint venture between MD Anderson Cancer Center and National Resilience. CEO Sarah Hein met her co-founder, Max Mamonkin, at the TMC Accelerator for Cancer Therapeutics. Along with fellow co-founder Malcolm Brenner, March Biosciences launched from the Center for Cell and Gene Therapy (Baylor College of Medicine, Houston Methodist Hospital and Texas Children’s Hospital). Its goal is to fight cancers that have been unresponsive to existing immunotherapies using its lead asset, MB-105.

An autologous CD5-targeted CAR-T cell therapy, MB-105 is currently in phase-1 trials in patients with refractory T-cell lymphoma and leukemia. The treatment is showing signs of being both safe and effective, meriting a phase-2 trial that will begin early next year. The funds raised from the series A will help to finance the Phase 2 clinical development of MB-105 to expand on the existing data with optimized manufacturing processes.

“This oversubscribed financing enables us to advance our first-in-class CAR-T therapy, MB-105, into a Phase 2 trial for T-cell lymphoma – an indication with an exceptionally poor prognosis and few treatment options,” says Hein. “With the support and confidence of our investors, we are not only advancing our lead program but also expanding our pipeline, underscoring our commitment to delivering best-in-class therapies to patients that can change the treatment paradigm for these challenging cancers.”

But that’s not the only exciting news that Hein and her associates have to report. March Biosciences has recently partnered with cell therapy venture studio, Volnay Therapeutics. Led by highly experienced cell therapy development veterans, the March Biosciences team will work to develop a scalable manufacturing process for MB-105 that will lead to commercialization. Volnay co-founder and CEO Stefan Wildt, who held key R&D leadership positions in cell and gene therapy units at Novartis and Takeda, has also joined the board of March Biosciences. The board of directors is also welcoming Cassidy Blundell of Mission BioCapital and Owen Smith of 4BIO Capital.

“The team at March Biosciences is leveraging powerful science and promising clinical data to tackle cancers with significant unmet need,” says Blundell, a partner at Mission BioCapital. “We're excited to support their journey and believe their focused approach with MB-105 could lead to significant breakthroughs in the CAR-T space.”

The Houston-born company, which is a finalist for the 2024 Houston Innovation Awards, continues to accelerate quickly, in part thanks to its home base. After all, existing local investors like TMC Venture Fund also participated in the new raise. As Hein said last year, “Working with partners here in Houston, we have all the pieces and the community rises to the occasion to support you.”

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Op-Ed: How tech can help keep health care workers safe

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Ask any healthcare worker, and they will have their own story of workplace violence. In the early years of my career, I narrowly missed encountering a gunman in the hospital ER solely because I forgot something and had to return upstairs. While tragedy was avoided in my case, too often, it is not. Such incidents are not isolated; in fact, they are becoming disturbingly common.

According to a report from National Nurses United, 81.6 percent of nurses said they experienced workplace violence in 2023.

As a physician, providing excellent patient care has always been my priority; however, any type of workplace violence disrupts quality care. When the supposedly safe spaces of healing and learning become targets, we must look at ways beyond hardening the exteriors to help prevent such violence within buildings.

For our healthcare systems, the answer may lie within our schools.

Since we lost our daughter and 16 of her classmates and staff at Marjory Stoneman Douglas High School in Parkland, Florida, six years ago, my wife and I have been advocating for enhanced school safety measures for classrooms across the nation.

Seven states have passed Alyssa's Law, named for our daughter, which requires the installation of wearable panic alarm technology in education settings. These alarms, which instantly link every classroom to emergency personnel while also providing mass communication to all staff, serve as a lifeline in times of crisis. These wearable panic alarms are not just outfitted for classrooms: they can be utilized in any workplace setting, including a healthcare system.

Despite their difference in purpose, healthcare facilities and schools share the unique properties of community spaces. Healthcare facilities are safe havens for those who need healing and rest within our community. No one should fear for their safety going to the doctor. Just as lawmakers have rethought and revised school safety requirements, they should do the same for healthcare facilities. Wearable safety technology has emerged as a formidable solution to this pressing issue.

Wearable, mobile duress badge technology is tailor-made for the unique challenges faced by healthcare workers. It is discrete, easy to use, and can be customizable for each healthcare campus. Some duress badge providers have technology that equips nurses, doctors and staff with badges that display their location and the ability to signal the level of emergency with a push of a button. They can use one badge for all campuses within a healthcare system, and they do not have to wait to get in touch with a hospital operator to “sound the alarm” or risk escalating a situation by lunging for a wall-mounted panic button.

Mobile panic alarms offer a nuanced and efficient response mechanism. Whether a minor incident or a life-threatening crisis, healthcare professionals can instantly summon help, ensuring a swifter and more coordinated response.

Texas was one of the first states to take on this alarming trend of workplace violence by passing SB240 last session, mandating facilities to establish a workplace violence prevention plan. Similar legislation is playing out in other states, becoming a nationwide movement.

I know healthcare facilities' budgets are tight these days with unprecedented rising costs of care and lower reimbursement rates. Still, through my personal journey in advocating for safety improvements in our educational institutions, I have learned one thing: you must invest in the future.

The adoption of wearable panic alarms is not just a security upgrade; it's a commitment to the well-being of those who dedicate their lives to provide healing and care. It's about protecting our community spaces. Like any other, the healthcare environment should be a sanctuary, free from the fear of violence. As Alyssa’s Law gains traction nationally, the spotlight now turns to healthcare facilities to embrace this critical technology.

Time, as we know too well, equals life. Swift action can be the difference between tragedy and survival. Investing in wearable panic alarm technology is an investment in our healthcare workforce's safety, resilience, and mental well-being. As we advocate for students to have a safe place to thrive, I am doing the same for healthcare places. The time has come to make our healthcare facilities safe.

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Dr. Ilan Alhadeff is the father of Alyssa Alhadeff, a victim of the February 14, 2018, school shooting at Marjory Stoneman Douglas High School, and co-founder of Make Our Schools Safe, a 501(c)(3) nonprofit organization dedicated to improving school safety.

NASA taps 4 participants for Mars habitat simulation mission in Houston

suiting up

Four individuals have been selected to go to Mars. Well, sort of.

Obaid Alsuwaidi, Kristen Magas, Tiffany Snyder, and Anderson Wilder were picked by NASA to live for 45 days in a 650-square-foot Mars simulation located at Johnson Space Center in Houston. The participants will enter the Human Exploration Research Analog, or HERA, on Friday, November 1, and will live and work like astronauts until Monday, December 16.

Jordan Hundley and Robert Wilson also were named as alternate crew members.

"Scientists use HERA studies to examine how crew members adapt to isolation, confinement, and remote conditions before NASA sends astronauts on deep space missions to the Moon, Mars, and beyond," reads NASA's announcement. "The studies provide data about human health and performance in an enclosed environment over time with crews facing different challenges and tasks."

In the experiment, the participants will complete research and operational duties, including raising shrimp, farming, and completing virtual reality-simulated walks on Mars. In addition to these tasks, the crew will experience communication delays similar to ones astronauts will face on future missions to Mars and beyond, which could be as long as 20 minutes each way.

Through NASA’s Human Research Program, the crew members will participate in 18 human health studies focused on physiological, behavioral, and psychological health during the mission.

Here's a little more about each of the crew members:

  • As captain engineer for the United Arab Emirates’ Ministry of Defense, Obaid Alsuwaidi, provides guidance in civil and marine engineering and addresses challenges facing the organization.
  • Kristen Magas, an educator and engineer currently teaching at Tri-County Regional Vocational Technical High School in Franklin, Massachusetts, mentors students involved in a NASA design and prototyping program.
  • With more than 20 years of information technology and cybersecurity experience, Tiffany Snyder is a supervisor for the Cybersecurity Mission Integration Office at NASA, helping to ensure agency missions are shielded against cybersecurity threats.
  • Currently researching team resiliency and human-machine interactions, Anderson Wilder is a Florida Institute of Technology graduate student working on his doctorate in Psychology and previously served as an executive officer and engineer for an analog mission at the Mars Desert Research Station in Utah.
  • Jordan Hundley (alternate) is a senior consultant at a professional services firm, offering federal agencies technical and programmatic support.
  • Robert Wilson (alternate) is a senior researcher and project manager at the Johns Hopkins University Applied Physics Laboratory in Laurel, Maryland.

Houston innovator drives EV adoption with unique approach to car leasing, smart tech

HOUSTON INNOVATORS PODCAST EPISODE 258

Switching from a gas-powered car to an electric one can be a big change, but a Houston-based company has made things a lot easier for its customers.

Octopus Electric Vehicles US, a spinout of United Kingdom-based retail energy provider Octopus Energy, matches its users with their perfect EV lease and sets them up with smart electricity technology for at-home charging.

"We do a couple of really unique things that are not only first of its kind but really innovative," Octopus EV's US Co-Lead Chris George says on the Houston Innovators Podcast, pointing out specifically Octopus Energy's Intelligent Octopus, a smart feature for customers that automates energy usage to lower cost.

"We launched an Intelligent Octopus for EVs service. Instead of operating in a very narrow window — overnight — it operates dynamically," he continues.


Pulling from the success of its British EV leasing business, Octopus EV helps Texans find their ideal car to lease from the available pre-owned EVs in the state. The process is hands on, George says, and he and his team are constantly working directly with customers to find them their right make, model, mileage, and more, then setting them up for free home charging with Octopus. All this for as low as $200 a month — perfect for both EV veterans and newbies alike.

"We serve a lot of people. What we're aiming to do is to drive adoption, and we're finding that for most people this is their first EV," George says, explaining that accessibility has been an issue for aspiring EV owners.

The company is rolling out a new process this week. In addition to providing its service in a match-making capacity, now Octopus EV will be showcasing EVs so that customers can browse, test drive, and really get to see what all they like before deciding on a car. George says this new process will be a bit of an experiment.

"We're gong to be showcasing inventory around Houston so customers can see the physical car, the lease price, test drive, and get the car you want," George says. "It's going to look and feel a little different from our current product, but it's going to serve customers just the same."

On the show, George, who previously led EV adoption-focused nonprofit Evolve Houston, shares a bit about the EV industry and what he's closely watching, including growth of charging stations, multifamily charging opportunities, battery technology for EVs and resilience, and perfecting messaging for new and returning customers.

"I'm always trying to think about where are the other things where we can unlock innovation, unlock ideas that help our industry and help Houstonians," George says.

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