3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Nick Skytland of NASA, Neal Dikeman of Energy Transition Ventures, and Bill McKeon of TMC. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from space tech to health care innovation — recently making headlines in Houston innovation.

Nick Skytland, chief technologist at NASA Johnson Space Center

Nick Skytland, chief technologist at NASA Johnson Space Center, joins the Houston Innovators Podcast. Photo via LinkedIn

For most people, it might be pretty hard to envision a future where astronauts are living on the moon or even Mars in the next few decades, but Nick Skytland, chief technologist at NASA Johnson Space Center, says he sees that future pretty clearly.

Since its inception in 1958, NASA has achieved many milestones, from the from putting the first man in orbit to having astronauts live in space for over 20 years consecutively. But it's a new era for NASA — and its commercial partners.

"What has changed in the past decade or so is that space flight is no longer just a government focus," Skytland says on the Houston Innovators Podcast. "We have an entire space industry that's growing and starting to thrive in the United States, and that's an important part of our strategy going forward." Read more.

Neal Dikeman, partner at Energy Transition Ventures

Houston-based energy tech investor Neal Dikeman writes his observations on Houston's venture capital and startup community's growth — in stark comparison of Silicon Valley's recent evolution. Photo via LinkedIn

In his guest column for InnovationMap, Neal Dikeman, a Houston-based energy transition investor, shares how Houston's innovation ecosystem differs from Silicon Valley these days. While deemed a newer ecosystem, there appears to be a growing amount of activity in and around the Ion, where Dikeman works out of. Meanwhile, Silicon Valley is pretty quiet.

"Founders are learning that Houston’s venture investment and tech scene has an actual home these days, and is open for business," he writes in the column. Read more.

Bill McKeon, CEO of the Texas Medical Center

Mayor Sylvester Turner, TMC CEO Bill McKeon, Governor Greg Abbott, and others gave their remarks at the TMC3 Collaborative Building opening. Photo via tmc.edu

For nearly a decade, thee Texas Medical Center and its partners have been working on the plans for Helix Park, a 37-acre campus expansion of TMC. As of this week, the first building has opened its doors to the public.

The TMC3 Collaborative Building officially opened today to a crowd of media, public officials, and health care executives. The institutional agnostic, 250,000-square-foot building will anchor Helix Park and house research initiatives from the four founding partners: Texas Medical Center, The University of Texas MD Anderson Cancer Center, Texas A&M University Health Science Center, and The University of Texas Health Science Center at Houston.

“Today, we lay the cornerstone of a new campus fully dedicated to streamlining the commercialization of life-changing innovations in medicine and technologies,” William McKeon, president and CEO of TMC, says at the event. “We are incredibly excited to both welcome our founding institutions and industry partners to the Collaborative Building and to invite the community to experience the Helix Park campus and its beautiful parks with a series of special events in the months ahead." Read more.

The Dynamic One building in TMC Helix Park is expected to deliver later this year. Rendering via TMC.edu

Rising TMC development names Houston health care institution as anchor tenant

coming soon

TMC Helix Park, formerly known as TMC3, has announced its first anchor tenant.

The Texas Medical Center and Beacon Capital Partners announced that Baylor College of Medicine will be the anchor tenant of the Dynamic One building at TMC Helix Park. The facility is will be the first to deliver of the four TMC Helix Park industry buildings. The Topped off in December, the Dynamic One building is being developed by Beacon in collaboration with Zoë Life Science and is scheduled to open before the end of the year.

“Beacon is excited that Dynamic One will be our first entry into the fast-growing Houston Life Science market,” says Fred Seigel, president and CEO of Beacon, in a news release. “This state-of-the-art environment is designed to enable and encourage collaboration and will greatly accelerate the innovative lifesaving discoveries that emerge when industry and academic research work side-by-side.”

Baylor College of Medicine will lease 114,000 square-feet of lab and office space in the 355,000-square-foot building. BCM's goal is to house lab space for novel diagnostics and therapeutics — and provide space to house startups.

The organization is expanding its presence in Houston after decades of residing in the region.

“Baylor College of Medicine moved to Houston in 1943 and was the first institution built in the Texas Medical Center," says Dr. Paul Klotman, president and CEO and executive dean of Baylor, in the release. "Our researchers and scientists will have the opportunity to access the uniquely concentrated research environment being developed at TMC Helix Park, facilitating the continuing advancement of innovation and compassionate care."

TMC Helix Park, which includes more than 5 million-square-feet of space across 37-acres, also expects to deliver its research facility, the TMC3 Collaborative Building, later this year.

“Baylor College of Medicine is a major force in life sciences discovery and commercialization at TMC," says Bill McKeon, president and CEO of TMC, in the release. "Their move to TMC Helix Park will serve as a catalyst for enhanced collaboration with TMC’s other esteemed Institutions, as well as with industry leaders from around the world."

BCM is the first anchor tenant announced for TMC Helix Park. Rendering via TMC.edu

TMC gave an update on TMC3 — now called TMC Helix Park — and introduced a new bioport project. Courtesy of Elkus Manfredi Architects

TMC unveils details of new bioport, Helix Park at annual Greater Houston Partnership event

coming soon

Within the next five to 10 years, the Texas Medical Center you know today will be double the size. That's what Bill McKeon, president and CEO of the TMC, said at yesterday's State of the Texas Medical Center event hosted by the Greater Houston Partnership.

The biggest project contributing to the TMC's growth is TMC3, a campus expansion that will bring 37 acres and 5 million square feet of space to the TMC, is now known as Helix Park. The name is a nod to the shape of the park and walkway design at the center of the campus. The TMC3 Collaborative Building — the first multi-institutional research facility in TMC’s history — will be the first of the project to deliver and is currently under construction and slated for completion in 2023.

However, the big news of the event was the TMC BioPort, the organization's upcoming biomanufacturing and medical supplies distribution engine. This new campus will span several hundred acres just down the road from TMC and will drive the much-needed repatriation of critical medical supplies and new cell and gene therapies, per a news release.

"During COVID, we saw the weakness of our supply chain," McKeon says at the event. "There is a huge effort by this country as a part of national security to make sure drug and vaccine production is moved back into the United States."

The new campus will also have an on-site upskill training center and create over 100,000 new job opportunities.

“Houston is advancing its position as the leading destination for life science discovery,” McKeon says in the release. “Through our holistic, expansive vision, we are building every vital component necessary to advance the largest life science ecosystem in the world.”

As explained at the event, the growing TMC is anchored by four districts: the TMC Medical Campus and the TMC Innovation Factory, which are already fully open and operating for years now, and the upcoming TMC Helix Park and TMC BioPort, which are both underway.


Bill McKeon gave the address at the State of the Texas Medical Center.

TMC3's Collaborative Building has topped out. Image courtesy of Texas Medical Center

First TMC3 Collaborative Building tops out, plans to open next year

medical milestone

Construction of Houston’s 250,000-square-foot TMC3 Collaborative Building has reached a milestone.

Founders of the research facility recently celebrated completion of the uppermost part of the building, known as “topping out.” Construction started in January 2021.

The building is part of the first phase of the TMC3 campus, a 37-acre life science property designed to capitalize on the intersection of medicine and commercialization. Founders of the campus are Texas Medical Center, the University of Texas MD Anderson Cancer Center, Texas A&M University Health Science Center, and the University of Texas Health Science Center at Houston.

The TMC3 Collaborative Building, set to open in 2023, will promote innovation and collaboration among the founding institutions, as well as with academic, healthcare, and industry partners. A key feature is a 43,000-square-foot research lab that’ll be shared by MD Anderson, Texas A&M Health, and UT Health Houston.

“The topping out of the TMC3 Collaborative Building marks an integral milestone in the future of life science research and innovation and reflects an unprecedented commitment to collaboration among the four founding institutions,” William McKeon, president and CEO of Texas Medical Center, says in a news release. “The lifesaving research and technologies that will come out of this building will truly revolutionize healthcare.”

In addition to the research lab, the building will include:

  • 85,000 square feet of lab and office space for industry partners.
  • 14,200 square feet for Texas Medical Center’s strategic initiatives, the Braidwell investment firm, the TMC Venture Fund, and national venture and equity fund partners.
  • A 7,000-square-foot atrium for lectures, programs, and informal events.

“Houston already has a place on the world stage as a leader in clinical care and life sciences. With the launch of the TMC3 Collaborative Building and larger TMC3 campus, we showcase why our city leads in the areas of innovation and technology,” Houston Mayor Sylvester Turner says. “In the process, we will create opportunities to bring new partners and industry to our city and generate new jobs for the residents of the Greater Houston community.”

For the first time, Accenture hosted its HealthTech Innovation Challenge finals at the Texas Medical Center's Innovation Institute. Photo courtesy of Accenture

2 startups win big at Accenture's ​Houston-based health tech competition

winner, winner

Two health tech companies walked away from Accenture's HealthTech Innovation Challenge with awards. Regionals took place in Boston and San Francisco, and Houston was selected to host the finals last week.

New York-based Capital Rx was selected as the 2020 Innovation Champion of the Accenture HealthTech Innovation Challenge, and Minneapolis-based Carrot Health was given the second-place award for Top Innovator. The program, which was first launched in 2016, aims to pair startups with health organizations to drive innovative solutions to real challenges in health care.

"The submissions we received this year demonstrate the momentum of discovery and digital innovation in healthcare," says Brian Kalis, managing director of digital health and innovation at Accenture, in a news release. "Healthcare organizations continue to advance their digital transformation agendas — enhancing access, affordability, quality and experience to drive innovation that improves the lives of consumers and clinicians. We look forward to working with these companies and others to continue to help advance solutions that address the industry's toughest challenges."

Capital Rx, a pharmacy benefit manager, won for its product, the Clearinghouse ModelSM, which connects pharmacies and employers for a more efficient and transparent way to coordinate prescriptions.

"Receiving the designation as Innovation Champion is a validation of our mission to change the way drugs are priced and administered, and it represents the broad support across the country to transform the antiquated and opaque pricing model for prescription drugs," says AJ Loiacono, CEO of Capital Rx, in the release.

Carrot Health, which took second place, has created algorithms to use consumer data analytics to predict and determine health issues. Its MarketView platform weighs in factors including social, economic, behavior, and environmental information.
 
"It's been a great opportunity to be with Accenture and a broad spectrum of health care players," says Kurt Waltenbaugh, CEO and founder of Carrot Health, in the release. "Being recognized as the Top Innovator will help us expand our footprint toward our goal to change health and serve every person in the U.S."

A total of 11 finalists pitched in Houston at TMCx on Feb, 6. The other finalists included: San Francisco-based Cleo, Boston-based DynamiCare Health, San Francisco-based InsightRX, United Kingdom-based Lantum, Washington, D.C.-based Mira, Denver-based Orderly Health, New York City-based Paloma Health, St. Louis-based TCARE, and Seattle-based Xealth.

It was the first time the challenge was hosted at the Texas Medical Center, and William F. McKeon, TMC president and CEO, took the stage at the event to share the medical city's vision for the future.

"The opportunity to host the HealthTech Innovation Challenge in Houston for the first time re-enforces our city's prominent and ever-expanding designation as a major hub for healthcare innovation nationwide," McKeon says in the release. "As Texas Medical Center heads into a new era of collaborative healthcare research on our forthcoming TMC3 campus, we look forward to maintaining a fruitful long-term partnership with Accenture."

The Texas Medical Center's CEO, Bill McKeon, ran down a list of exciting updates and innovations from the organization's member institutions at the annual State of the TMC. Photo via tmc.edu

From robots to immunotherapy, TMC talks innovation at its annual address

check up

In the Greater Houston Partnership's annual State of the Texas Medical Center address, TMC CEO Bill McKeon shared a status update of sorts for all the goings on at the largest medical center in the world.

McKeon ran down the list of member institutions to briefly touch base on each organization's innovations and growth. In the address, which took place at the Marriott Marquis on October 31, McKeon discussed exciting construction projects, new accelerator programs, and more. Here are some of the highlights from the presentation.

TMC3 and beyond

The TMC spans 1,400 acres and 50 million square feet of development — and growing. The largest medical city in the world will increase its size by 10 percent in the next two to three years, McKeon says. Here are some updates on each of the ongoing construction projects.

  • TMC3 is underway. The 37-acre research campus is expected to be completed in 2022.
  • CHI St. Luke's McNair Campus is expected to break ground on a new building before the end of the year.
  • Memorial Hermann's Sarofim Building is expected to open in 2020 with 18 stories, 26 new operating rooms, and 144 beds
  • Rice University has moved its synthetic biology program to BioScience Research Collaborative in the TMC.
  • Texas A&M University's EnMed program, which graduates students with a master's in engineering and a MD in four year, has launched. The university's med center building is underway at 1020 Holcombe, and is expected to be completed next May.
  • The University of Houston's new medical school us up and running, and the inaugural class's tuition was completely funded by an anonymous donor.
  • UTHealth's psychiatric hospital is expected to be the largest academic psychiatry hospital in country. The building is under construction and will be completed in 2021.

Building biobridges

In order to grow the TMC's global presence and bring the best innovations from around the world to Houston, McKeon says the organization has expanded its BioBridge partnerships.

The first partnership was with Australia in 2016, before the organization teamed up with the United Kingdom for the second one. Recently, the TMC has entered into its third BioBridge partnership with Denmark.

The partnerships are intended to encourage collaboration, particularly with TMCx. Now, TMCx startups break down from being a third of the companies from around the world, a third from other states in the U.S., and a third being from Texas.

"There's no greater collection of minds, patients, resources to really think about the next innovations in health care," Mckeon says.

Accelerating accelerators

TMCx is celebrating its fifth year and has worked with over 170 companies through its digital health and medical device accelerator programs.

"We're evolving to start to work more closely with our member institutions to understand their specific needs and how we can match novel technologies through them," says Lance Black, associate director of TMCx.

The TMC Innovation Institute supports 12 programs, and three have been introduced just this year.

  • TMCxi: A 40,000-square-foot space to support industry partners, investors, and other service providers that provides subject matter expertise and other resources for entrepreneurs.
  • TMCalpha: Programming for TMC doctors and staff who may have an idea for a new technology or startup.
  • TMC | ACT: An accelerator program for advancing cancer therapeutics and technologies.

Investing in robotics

Earlier this year, TMC announced plans to open a special robotics lab space with ABB Robotics. The space officially opened last month.

"Many of the things we do in our labs require pinpoint accuracy," McKeon says. "Many of the things we do now here are done by humans, but in the future, we have one of the most sophisticated robotics companies in the world thinking about how we can transform our labs."

The lab is just the beginning of ABB's connection to TMC and its member institutions.

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Houston hardtech accelerator names 8 scientists to 2025 cohort

ready, set, activate

National hardtech-focused organization Activate has named its 2025 cohort of scientists, which includes new members to Activate Houston.

The Houston hub was introduced last year, and joins others in Boston, New York, and Berkley, California—where Activate is headquartered. The organization also offers a virtual and remote cohort, known as Activate Anywhere. Collectively, the 2025 Activate Fellowship consists of 47 scientists and engineers from nine U.S. states.

This year's cohort comprises subject matter experts across various fields, including quantum, robotics, biology, agriculture, energy and direct air capture.

Activate aims to support scientists at "the outset of their entrepreneurial journey." It partners with U.S.-based funders and research institutions to support its fellows in developing high-impact technology. The fellows receive a living stipend, connections from Activate's robust network of mentors and access to a curriculum specific to the program for two years.

“Science entrepreneurship is the origin story of tomorrow’s industries,” Cyrus Wadia, CEO of Activate, said in an announcement. “The U.S. has long been a world center for science leadership and technological advancement. When it comes to solving the world’s biggest challenges, hard-tech innovation is how we unlock the best solutions. From infrastructure to energy to agriculture, these Activate Fellows are the bold thinkers who are building the next generation of science-focused companies to lead us into the future.”

The Houston fellows selected for the 2025 class include:

  • Jonathan Bessette, founder and CEO of KIRA, which uses its adaptive electrodialysis system to treat diverse water sources and reduce CO2 emissions
  • Victoria Coll Araoz, co-founder and chief science officer of Florida-based SEMION, an agricultural technology company developing pest control strategies by restoring crops' natural defenses
  • Eugene Chung, co-founder and CEO of Lift Biolabs, a biomanufacturing company developing low-cost, nanobubble-based purification reagents. Chung is completing his Ph.D. in bioengineering at Rice University.
  • Isaac Ju, co-founder of EarthFlow AI, which has developed an AI-powered platform for subsurface modeling, enabling the rapid scaling of carbon storage, geothermal energy and lithium extraction
  • Junho Lee, principal geotechnical engineer of Houston-based Deep Anchor Solutions, a startup developing innovative anchoring systems for floating renewables and offshore infrastructure
  • Sotiria (Iria) Mostrou, principal inventor at Houston-based Biosimo Chemicals, a chemical engineering startup that develops and operates processes to produce bio-based platform chemicals
  • Becca Segel, CEO and founder of Pittsburgh-based FlowCellutions, which prevents power outages for critical infrastructure such as hospitals, data centers and the grid through predictive battery diagnostics
  • Joshua Yang, CEO and co‑founder of Cambridge, Massachusetts-based Brightlight Photonics, which develops chip-scale titanium: sapphire lasers to bring cost-effective, lab-grade performance to quantum technologies, diagnostics and advanced manufacturing

The program, led locally by Houston Managing Director Jeremy Pitts, has supported 296 Activate fellows since the organization was founded in 2015. Members have gone on to raise roughly $4 billion in follow-on funding, according to Activate's website.

Activate officially named its Houston office in the Ion last year.

Charlie Childs, co-founder and CEO of Intero Biosystems, which won both the top-place finish and the largest total investment at this year's Rice Business Plan Competition, was named to the Activate Anywhere cohort. Read more about the Boston, New York, Berkley and Activate Anywhere cohorts here.

Houston team’s discovery brings solid-state batteries closer to EV use

A Better Battery

A team of researchers from the University of Houston, Rice University and Brown University has uncovered new findings that could extend battery life and potentially change the electric vehicle landscape.

The team, led by Yan Yao, the Hugh Roy and Lillie Cranz Cullen Distinguished Professor of Electrical and Computer Engineering at UH, recently published its findings in the journal Nature Communications.

The work deployed a powerful, high-resolution imaging technique known as operando scanning electron microscopy to better understand why solid-state batteries break down and what could be done to slow the process.

“This research solves a long-standing mystery about why solid-state batteries sometimes fail,” Yao, corresponding author of the study, said in a news release. “This discovery allows solid-state batteries to operate under lower pressure, which can reduce the need for bulky external casing and improve overall safety.”

A solid-state battery replaces liquid electrolytes found in conventional lithium-ion cells with a solid separator, according to Car and Driver. They also boast faster recharging capabilities, better safety and higher energy density.

However, when it comes to EVs, solid-state batteries are not ideal since they require high external stack pressure to stay intact while operating.

Yao’s team learned that tiny empty spaces, or voids, form within the solid-state batteries and merge into a large gap, which causes them to fail. The team found that adding small amounts of alloying elements, like magnesium, can help close the voids and help the battery continue to function. The team captured it in real-time with high-resolution videos that showed what happens inside a battery while it’s working under a scanning electron microscope.

“By carefully adjusting the battery’s chemistry, we can significantly lower the pressure needed to keep it stable,” Lihong Zhao, the first author of this work, a former postdoctoral researcher in Yao’s lab and now an assistant professor of electrical and computer engineering at UH, said in the release. “This breakthrough brings solid-state batteries much closer to being ready for real-world EV applications.”

The team says it plans to build on the alloy concept and explore other metals that could improve battery performance in the future.

“It’s about making future energy storage more reliable for everyone,” Zhao added.

The research was supported by the U.S. Department of Energy’s Battery 500 Consortium under the Vehicle Technologies Program. Other contributors were Min Feng from Brown; Chaoshan Wu, Liqun Guo, Zhaoyang Chen, Samprash Risal and Zheng Fan from UH; and Qing Ai and Jun Lou from Rice.

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This article originally appeared on EnergyCaptialHTX.com.

Rice biotech accelerator appoints 2 leading researchers to team

Launch Pad

The Rice Biotech Launch Pad, which is focused on expediting the translation of Rice University’s health and medical technology discoveries into cures, has named Amanda Nash and Kelsey L. Swingle to its leadership team.

Both are assistant professors in Rice’s Department of Bioengineering and will bring “valuable perspective” to the Houston-based accelerator, according to Rice. 

“Their deep understanding of both the scientific rigor required for successful innovation and the commercial strategies necessary to bring these technologies to market will be invaluable as we continue to build our portfolio of lifesaving medical technologies,” Omid Veiseh, faculty director of the Launch Pad, said in a news release.

Amanda Nash

Nash leads a research program focused on developing cell communication technologies to treat cancer, autoimmune diseases and aging. She previously trained as a management consultant at McKinsey & Co., where she specialized in business development, portfolio strategy and operational excellence for pharmaceutical and medtech companies. She earned her doctorate in bioengineering from Rice and helped develop implantable cytokine factories for the treatment of ovarian cancer. She holds a bachelor’s degree in biomedical engineering from the University of Houston.

“Returning to Rice represents a full-circle moment in my career, from conducting my doctoral research here to gaining strategic insights at McKinsey and now bringing that combined perspective back to advance Houston’s biotech ecosystem,” Nash said in the release. “The Launch Pad represents exactly the kind of translational bridge our industry needs. I look forward to helping researchers navigate the complex path from discovery to commercialization.”

Kelsey L. Swingle

Swingle’s research focuses on engineering lipid-based nanoparticle technologies for drug delivery to reproductive tissues, which includes the placenta. She completed her doctorate in bioengineering at the University of Pennsylvania, where she developed novel mRNA lipid nanoparticles for the treatment of preeclampsia. She received her bachelor’s degree in biomedical engineering from Case Western Reserve University and is a National Science Foundation Graduate Research Fellow.

“What draws me to the Rice Biotech Launch Pad is its commitment to addressing the most pressing unmet medical needs,” Swingle added in the release. “My research in women’s health has shown me how innovation at the intersection of biomaterials and medicine can tackle challenges that have been overlooked for far too long. I am thrilled to join a team that shares this vision of designing cutting-edge technologies to create meaningful impact for underserved patient populations.”

The Rice Biotech Launch Pad opened in 2023. It held the official launch and lab opening of RBL LLC, a biotech venture creation studio in May. Read more here.

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