BBVA, which recently went through a rebranding process, selected two Houston startups for its accelerator program. Photo via bbva.com

Two socially minded entrepreneurs in Houston are getting a big boost from a bank-sponsored accelerator program.

The pair of entrepreneurs — leaders of socially focused ventures Eight Million Stories and Small Places LLC — are among 19 social entrepreneurs from across the U.S. chosen to join the BBVA Momentum accelerator program.

This year, BBVA Momentum features five months of online and in-person education lasting from June to November. Headspring Executive Development by Financial Times runs the online component, while the University of Texas at Austin's McCombs School of Business manages the in-person training. Each social entrepreneur is paired with a mentor from banking giant BBVA to provide one-on-one support throughout the program.

At the end of the program, BBVA awards prizes to ventures that have been identified as being highly sustainable and creating the most social impact. Last year's top venture took home $75,000 in equity funding.

Eight Million Stories

One of the two Houston-based startups that was selected for the program is Eight Million Stories, which was founded by Marvin Pierre. The organization helps formerly incarcerated youth (16 to 18 years old) through a free, voluntary four-month program designed to help them:

  • Build strong relationships in their communities.
  • Gain access to an array of social services.
  • Develop life and job skills.
  • Continue their education.
  • Secure meaningful employment.

Pierre says his program "seeks to upend the school-to-prison pipeline by supporting previously incarcerated young people in successfully transitioning back into their communities, and by curbing unnecessary referrals from schools to the juvenile justice system."

Pierre hopes to eventually roll out Eight Million Stories across the country.

"We believe that there are a lot of commonalities in terms of why kids end up in the juvenile justice system, whether it's broken homes or lack of support in the school system or other factors," Pierre says. "If you interview every kid in the system, you'll find there's a common thread. That's what we're trying to undo. If we attack those commonalities, then we can aggressively work to dismantle the school-to-prison pipeline."

Small Places

Finca Tres Robles/Instagram

Today, the main focus of Small Places, co-founded by Daniel Garcia-Prats, is Finca Tres Robles (Spanish for Three Oaks Farm), Houston's only private farm inside the 610 Loop. The farm grows fruits, vegetables, and herbs that are sold to consumers directly by the farm and at local farmers markets.

"Agriculture is fundamentally about people, not plants," Finca Tres Robles says on its website. "While food is central to the work we do, the farm has the capabilities to impact other important areas of health. As an organization, our focus is on developing farms and agricultural spaces that can provide critical health-related services to communities that are need of basic infrastructure to support health."

Among the farm's projects is the Pre-K Produce Program. Finca Tres Robles estimates that thanks to the program, anywhere from $250,000 to $1.25 million in healthcare costs will be saved over the lifetime of the preschoolers.

Small Places also helps run the community farm at the Harris Health System's Lyndon B. Johnson Hospital and operates Houston's 3 Oaks Farms, which focuses on production of the moringa tree, the source of a nutrient-packed superfood.

In a nutshell, Small Places offers:

  • Farm development, management, and consulting services.
  • Education.
  • Community outreach.
  • Job training.

Small Places says it concentrates on "placemaking and community health, helping community- and health-related nonprofits, municipalities that have food security/access issues and progressive commercial developers that want to establish a culture of health in their neighborhoods."

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”