Baylor, Rice win $500,000 to launch humanities-driven health AI center

ethical AI

A new center being developed by Baylor College of Medicine and Rice University aims to develop ethically responsible and trustworthy AI for health care. Photo via Getty Images.

Baylor College of Medicine and Rice University have been awarded a $500,000 grant from the National Endowment for the Humanities (NEH) to create the Center for Humanities-based Health AI Innovation (CHHAIN).

The new center and three-year initiative aims to create ethically responsible and trustworthy AI for health care that uses history and patient narratives to shape the technology, according to a release. It represents a collaboration between the Center for Medical Ethics and Health Policy at Baylor and the Medical Humanities Research Institute at Rice. Ultimately, the researchers aim to establish a national model for integrating the humanities into the design and implementation of health AI.

Vasiliki Rahimzadeh, assistant professor at Baylor in the Center for Medical Ethics and Health Policy, and Kirsten Ostherr, director of the Medical Humanities Research Institute at Rice, will serve as co-directors of the new center, which will be housed within the Center for Medical Ethics.

The team will also engage in strategic collaborations with Kirstin Matthews, Rice’s Baker Institute for Public Policy and its fellow in science and technology policy, as well as Dr. Quianta Moore, executive director of the Meadows Mental Health Policy Institute. An interdisciplinary team of medical humanities and bioethics scholars from Baylor, Rice, and partners in the Houston area will complete the group.

“CHHAIN represents a bold new model for integrating the humanities into health innovation,” Ostherr said in a news release. “It will create a collaborative space where humanities scholars, patients, developers and clinicians can come together to explore the human dimensions of health AI—trust, narrative and lived experience. These are essential perspectives that are too often missing from technology development, and CHHAIN is designed to change that."

CHHAIN’s work will revolve around three key points:

Defining trustworthy AI through patient voices
Translating humanities insights into clinical AI settings
Public engagement and policy translation

“For AI to truly improve health outcomes, it must be designed with patient trust and wellbeing at its core,” Rahimzadeh said in the news release. “CHHAIN will provide a dedicated space to explore critical bioethics questions, such as how we ensure AI respects patient autonomy, addresses the needs of underserved communities and integrates meaningfully into clinical care. Our goal is to translate these insights into real-world health settings where AI is already shaping patient experiences."

CHHAIN's research mission was also developed thanks to pilot funding from the Margaret M. and Albert B. Alkek Department of Medicine at Baylor and a grant from Rice's Provost's TMC Collaborator Fund.

Texas A&M, the University of North Texas and the University of Texas at El Paso were also home to some of the 97 projects that received a portion of the $34.79 million in fundning from the NEH. See the full list here.

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A new study declares that Houston boasts the talent pool, tax advantages, and business-friendly environment to lead in energy transitions. Photo via Getty Images

Houston is uniquely ready for the energy transition, Rice University research finds

seeing green

These days, the term "green energy" has quickly evolved from a potential new resource avenue to political lighting rod — especially in Houston. But now, a new report suggests that the nation's oil and gas leader could be primed to be a green leader.

Houston's "energy capital of the world" status is here to stay — no matter the type of energy — says a new report from Rice University's Baker Institute for Public Policy. The study declares that Houston boasts the talent pool, tax advantages, and business-friendly environment to lead in energy transitions.

"With the Port of Houston consistently ranked the nation's largest for waterborne tonnage, foreign imports and vessel transits, Houston has earned its stripes as a global epicenter for logistics and complex supply chain operations," Rice's Ken Medlock notes.

"Managing supply chains, handling materials and deep expertise in chemistry and engineering are all skill sets that drive the oil and gas industry, and they form the basis of Houston's comparative advantage. All are transferable, and will remain important for the development and delivery of all energy services."

The Bayou City is actually "well-positioned" to pioneer the continuing evolution of the global energy system, the study continues.

Public perception aside, Texas is already prepared for the green energy transition, Medlock continues, offering up these stats:

Texas already has more wind capacity than any other state (more than 26 percent of the entire U.S.), and the Lone Star State is home to almost 10 percent of the nation's installed solar capacity and 10 percent of the nation's installed battery capacity

Texas currently accounts for 20 percent of the nation's total non-hydro renewable power capacity, despite only accounting for only 11 percent of the nation's total installed generation capacity.

"This means Texas is ranked No. 1 in wind capacity, No. 2 in battery capacity and No. 3 in solar capacity among every state in the U.S., which puts Texas at the top of all states in terms of installed green power technology capacity," says Medlock.

Brainy Rice University institute named No. 1 think tank in the world

top dog

Furthering its reputation as a world-class educational and intellectual hallmark, Rice University has ascended to the top of yet another ranking.
The school's Baker Institute for Public Policy has been named the No. 1 think tank in the world, according to the 2020 Global Go To Think Tank Index Report published January 28. This is a leap from No. 2 overall last year.

Additionally, its Center for Energy Studies (CES) was again named the top energy and resource policy think tank and was recognized as a Center of Excellence for being ranked No. 1 for three consecutive years, per a press release.

Rice's Baker Institute is also ranked No. 15 out of 110 of the top think tanks in the U.S. overall. It is also listed among the best think tanks globally in the category "Best Quality Assurance and Integrity Policies and Procedures."

Also on the prestigious list are the London School of Economics and Political Science (No. 2) and Institute of Development Studies at the University of Sussex, U.K. (No. 3).

Meanwhile, CES is followed in the regular rankings by the Oxford Institute for Energy Studies, U.K., and the Institute of Energy Economics, Japan.

Founded in 1993, the Baker Institute houses fellows and scholars who conduct research on domestic and foreign policy issues. Core fields of study include energy, the Middle East, Mexico, health policy, public finance, private entrepreneurship and economic growth, international economics, presidential elections, science and technology, China, space policy, and drug policy, according to the school.

CES was founded in October 2012 and provides policymakers, corporate leaders, and the public with quality, data-driven analysis of issues that influence energy markets, per Rice. The Baker Institute Energy Forum is considered an integral part of CES by the university.

"The rise of the Baker Institute and our Center for Energy Studies to the very top rankings in this year's Global Go To Think Tank Index is the culmination of what we created over a quarter of a century ago and of our adherence to excellence in data-driven, nonpartisan research and policy recommendations on public policy issues that reach decision-makers in the private and public sectors," said Baker Institute director Edward Djerejian, in a statement. "I commend all our fellows, scholars and staff, as well as our Board of Advisors and Roundtable members, for this outstanding achievement."

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This article originally ran on CultureMap.

Rice's Baker Institute could change the fortunes of rural Texans. Photo via rice.edu

Houston program in the running for prestigious $10 million prize

Rice to the rescue

Rice University is once again in the spotlight for innovation, this time for its work in potentially assisting rural communities across the Lone Star State. And this idea could score the university a $10 million prize.

A new project proposed by the Rice's Baker Institute for Public Policy is among five finalists for the coveted Lone Star Prize, the school announced. The Baker Institute project proposal, titled "Texas Dirt: The Key to Environment, Economy and Resilience," aims to transform the state's environment "through implementation of a soil carbon storage market while growing new economic opportunities for rural Texans" according to a press release.

Atmospheric accumulation of carbon dioxide (CO2) contributes to climate change, which disproportionately affects poor and marginalized populations, according to the Baker Institute team.

"Rural communities have long been disadvantaged relative to the urban and industrial centers that are focal points for economic activity and CO2 emissions," the team wrote in a project description. "A soil carbon market is a Texan approach that addresses both of these issues as part of a long-term solution." The team aims to "implement a Texas soil carbon storage market that utilizes photosynthesis to abate atmospheric CO2 by storing it as organic matter in soils of prairies, farms, ranches and grasslands of Texas."

Beyond an economic boost, say the team, benefits the Texas water supply, regional flood resilience, and the restoration of local ecosystems.

As for the prestigious prize, the Texas-based, statewide competition was launched in early 2020 by Lyda Hill Philanthropies and Lever for Change to improve the lives of Texans and their communities, per a statement.

Project members include attorney Jim Blackburn, a professor in the practice of environmental law at Rice and co-director of the university's Severe Storm Prediction, Education and Evacuation from Disasters Center (SSPEED); Caroline Masiello, a professor of Earth, Environmental and Planetary Sciences at Rice; and Kenneth Medlock, the James A. Baker III and Susan G. Baker Fellow in Energy and Resource Economics and senior director of the Baker Institute's Center for Energy Studies.

Other statewide finalists include Austin's JUST Community, which invests in low-income, female entrepreneurs to create more resilient communities in the U.S.; Dallas-based Meadows Mental Health Policy Institute, which will will improve quality of life and mental health access; the Dallas location of Merit America, which will will build new pathways to upwardly mobile careers for low-wage Texans without bachelor's degrees; and Austin's Texas Water Trade, which aims to deliver clean water to households most in need.

More than 172 proposals were submitted for the Lone Star Prize. A final grant recipient will be announced in late spring 2021.

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This article originally ran on CultureMap.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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