Paying a per-employee fee, companies can give their team access to a one-stop-shop approach to medical care with Crossover. Courtesy of Crossover

Information technology provider HP Inc. and other major employers in the Houston area are exploring a new way to offer medical care to their employees.

A California company called Crossover Health just opened a 5,300-square-foot medical clinic in Spring. The clinic — Crossover Health's first in the Houston area — enables several self-insured employers to share one provider of primary healthcare services for their employees in an effort to cut costs and promote convenience.

Aside from primary medical care, offerings at the Spring clinic include physical therapy, and chiropractic, acupuncture, and fitness services. Each employer pays a monthly per-employee fee for access to Crossover Health.

At the Spring center, Crossover Health seeks to act on its "belief that healthcare should be convenient, simple to navigate, affordable, and personalized."

The Spring location, at 28420 Hardy Toll Road, features four rooms for primary care, and two each for physical therapy, acupuncture, and health coaching. At the outset, the clinic employs 13 people, but more hires are planned as Crossover Health adds clients there.

Palo Alto, California-based HP is the only client of the Spring clinic that Crossover Health is permitted to identify. In February, HP moved about 2,400 employees into its new two-building, 12-acre campus at Springwoods Village, a master-planned community just west of the Crossover Health clinic. Later this year, San Jose, California-based Hewlett Packard Enterprise Co., a sister company of HP, is scheduled to kick off construction of a new campus at Springwoods Village.

Neighboring employers include ExxonMobil, Southwestern Energy, and the American Bureau of Shipping.

For employers, Crossover Health operates medical clinics that are at or near worksites. Outside the Houston area, Crossover Health's corporate clients include Apple, LinkedIn, and Visa.

Larry Boress, executive director of the Dallas-based National Association of Worksite Health Centers, says clinics like Crossover Health's can reduce travel time for employees heading to medical appointments and, as a result, can improve productivity.

"The value of a worksite health and wellness center for both large and small employers in Houston is that it offers the ability to gain real value on their healthcare investment," Boress says.

Aside from trimming healthcare costs, such centers can boost employee satisfaction and decrease absenteeism, he says.

"These centers have also been found to help employers be an employer of choice, benefiting recruitment and retention of employees," Boress says.

A 2018 survey by consulting firm Mercer and the National Association of Worksite Health Centers found that in 2017, one-third of U.S. employers with at least 5,000 employees provided worksite medical clinics, up from almost one-fourth in 2012.

A different survey — this one conducted in 2018 by the National Association of Worksite Health Centers and Benfield, a market research, strategy, and communications consulting firm that focuses on the healthcare industry — showed that among large employers with some sort of medical arrangement, 63 percent offered on-site clinics, 16 percent offered nearby clinics, and 21 percent offered a mix of the two.

"The hope with on-site or near-site clinics is to make healthcare more convenient for employees, and along the way ideally cheaper by cutting down on visits," Business Insider reported in 2018. "Crossover says it can save as much as $970 per member compared to what employers would be paying if that employee went through the traditional healthcare system. That savings can add up for a company with thousands of employees."

Crossover Health already has brought its brand of healthcare delivery to Austin and San Antonio. Now that the company has planted its flag in the Houston market, it's eyeing its first location in Dallas-Fort Worth.

"Texas, which has consistently ranked as the top U.S. state for business and job growth, is one of our most important markets as we continue to expand our national footprint," Dr. Scott Shreeve, co-founder and CEO of Crossover Health, says in a release. "The new Spring center allows us to introduce our new model of primary care to an increasing number of corporations moving to the Lone Star State."


features four rooms for primary care, and two each for physical therapy, acupuncture, and health coaching.Courtesy of Crossover Health

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.