The local community has raised some concerns about Rice Management Company's Ion project's effect on the Third Ward. Courtesy of Rice University

The city of Houston has been buzzing about Rice Management Company's Ion Innovation Hub — a 270,000-square-foot coworking and innovation hub project expected to deliver in 2021 — but there's one group isn't so thrilled with the plans: The Third Ward community.

In a public community meeting on November 12, community members gathered at the Wesley AME Church to plan a Community Benefits Agreement that would legally bind The Innovation District's development team and the Rice Management Company to move forward with the local residents' indicated best interests. According to the Houston Coalition for Equitable Development without Displacement, a newly formed group to work on the CBA, it would be the first of its kind in Houston.

The coalition is supported by Third Ward is Home Civic Club, the Emancipation Economic Development Council, the Texas Coalition of Black Democrats - Harris County, and the Houston Society for Change.

Gabriella Rowe, executive director of The Ion, presented the project's plans to the crowd, recognizing that innovation ecosystems across the country have issues with diversity.

"When you look around the tech ecosystems in the United States today, there are a couple things that stand out," Rowe says. "First and foremost is that they are extremely white and extremely male."

But since Houston is still developing its innovation infrastructure, Rowe says, the city has more opportunities to take the lessons learned from these other ecosystems and be more proactive about including diverse efforts.

One of the things The Ion is planning to incorporate to engage the community is a free coworking space — the only free coworking space in Houston, Rowe says. The Ion plans also include two public parks and community events, and both will be free and open to the public.

The Ion promises to bring free coworking, park space, and events to the area. Courtesy of Rice University

After the presentation, the estimated 150 community members in the crowd had the opportunity to address Rowe. While one local resident expressed concern with the non-inclusive verbiage The Ion is using — describing the area as "Midtown" over the pre-gentrification descriptor of Third Ward — other concerns surrounded the lack of diversity of the decision makers on the project.

"For me, that's where we need to start, which is in diversity," says Rowe, who mentions she has diversity among her programming team. "I look to all of you to come to get included in our team as we're growing."

Another concern that was raised was the job opportunities on the construction site itself. While Rowe didn't mention any specific job opportunities in construction, she did say she had been asked by the Rice Management Company to tap local artists to design the fences surrounding the site.

The meeting pivoted toward a discussion about the CBA and the importance the agreement would have moving forward. Assata Richards, founder of Sankofa Research Institute and local activist, and Mary Claire Neal, a Rice University student and leader of the Students for a Just and Equitable Innovation Corridor, and Carl Davis, chair of the Houston Society for Change and a representative of the church, have teamed up to move forward with the agreement.

Texas Appleseed, a group of volunteer lawyers, has agreed to help create and enforce the agreement, and Jeffrey Lowe, associate professor in the department of urban planning and environmental policy at Texas Southern University, has also advised the organizations.

"We've been told what's going to happen, but there's no binding agreement to make sure that it's going to happen," Richards says. "Those are just nice wishlists."

Moreover, the initiatives that have been suggested, enforceable or not, aren't enough, Richards adds, again stressing the importance of the CBA.

"We're going to be smarter this time. We're going to work with the people who have the power and make the decisions," Richards says. "You're doing all this development and come and tell me that you want art outside the building? We're talking millions of dollars of construction."

While the terms of the CBA are still in the works, some of the requests mentioned in the meeting include jobs, preservation of communities of color, affordable housing initiatives, access to affordable groceries, and opportunities for minority and African American-owned businesses.

The Ion Innovation Hub Proposed Site PlanThe Ion Innovation Hub Proposed Site Plan was included in notes pre-released ahead of the Houston Planning Commission's November 14 meeting. Photo via HPC

Neal proceeded with a presentation of actionable ways students and community members can get involved and make their voices heard. Her presentation included new concerns following the release of the master plan of The Innovation District, which the Houston Chronicle released earlier this week. The plans included a parking area that will be the next construction project following The Ion. The variance request is headed to the planning commission on Thursday.

"That's a two-day turnaround and it's the first opportunity for us to do something," Neal says. The group is intending to at least acquire a delay in the variance request moving forward.

The meeting wrapped up with a call to action for local residents as well as students. Since The Ion will include local academic institutions, student and alumni input is crucial.

"We want you to hold up and pause and think carefully on how this development is going to benefit and affect the community," Richards says.

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Clinical-stage Houston cell therapy company closes $28.4M oversubscribed series A

cha-ching

An emerging biotech company in Houston has closed its series A with outsized success.

March Biosciences' oversubscribed raise brought in $28.4 million of financing with Mission BioCapital and 4BIO Capital leading the pack of investors. The company has now raised more than $51 million in total.

Last year, March Biosciences announced its strategic alliance with CTMC (Cell Therapy Manufacturing Center), a joint venture between MD Anderson Cancer Center and National Resilience. CEO Sarah Hein met her co-founder, Max Mamonkin, at the TMC Accelerator for Cancer Therapeutics. Along with fellow co-founder Malcolm Brenner, March Biosciences launched from the Center for Cell and Gene Therapy (Baylor College of Medicine, Houston Methodist Hospital and Texas Children’s Hospital). Its goal is to fight cancers that have been unresponsive to existing immunotherapies using its lead asset, MB-105.

An autologous CD5-targeted CAR-T cell therapy, MB-105 is currently in phase-1 trials in patients with refractory T-cell lymphoma and leukemia. The treatment is showing signs of being both safe and effective, meriting a phase-2 trial that will begin early next year. The funds raised from the series A will help to finance the Phase 2 clinical development of MB-105 to expand on the existing data with optimized manufacturing processes.

“This oversubscribed financing enables us to advance our first-in-class CAR-T therapy, MB-105, into a Phase 2 trial for T-cell lymphoma – an indication with an exceptionally poor prognosis and few treatment options,” says Hein. “With the support and confidence of our investors, we are not only advancing our lead program but also expanding our pipeline, underscoring our commitment to delivering best-in-class therapies to patients that can change the treatment paradigm for these challenging cancers.”

But that’s not the only exciting news that Hein and her associates have to report. March Biosciences has recently partnered with cell therapy venture studio, Volnay Therapeutics. Led by highly experienced cell therapy development veterans, the March Biosciences team will work to develop a scalable manufacturing process for MB-105 that will lead to commercialization. Volnay co-founder and CEO Stefan Wildt, who held key R&D leadership positions in cell and gene therapy units at Novartis and Takeda, has also joined the board of March Biosciences. The board of directors is also welcoming Cassidy Blundell of Mission BioCapital and Owen Smith of 4BIO Capital.

“The team at March Biosciences is leveraging powerful science and promising clinical data to tackle cancers with significant unmet need,” says Blundell, a partner at Mission BioCapital. “We're excited to support their journey and believe their focused approach with MB-105 could lead to significant breakthroughs in the CAR-T space.”

The Houston-born company, which is a finalist for the 2024 Houston Innovation Awards, continues to accelerate quickly, in part thanks to its home base. After all, existing local investors like TMC Venture Fund also participated in the new raise. As Hein said last year, “Working with partners here in Houston, we have all the pieces and the community rises to the occasion to support you.”

NASA taps 4 participants for Mars habitat simulation mission in Houston

suiting up

Four individuals have been selected to go to Mars. Well, sort of.

Obaid Alsuwaidi, Kristen Magas, Tiffany Snyder, and Anderson Wilder were picked by NASA to live for 45 days in a 650-square-foot Mars simulation located at Johnson Space Center in Houston. The participants will enter the Human Exploration Research Analog, or HERA, on Friday, November 1, and will live and work like astronauts until Monday, December 16.

Jordan Hundley and Robert Wilson also were named as alternate crew members.

"Scientists use HERA studies to examine how crew members adapt to isolation, confinement, and remote conditions before NASA sends astronauts on deep space missions to the Moon, Mars, and beyond," reads NASA's announcement. "The studies provide data about human health and performance in an enclosed environment over time with crews facing different challenges and tasks."

In the experiment, the participants will complete research and operational duties, including raising shrimp, farming, and completing virtual reality-simulated walks on Mars. In addition to these tasks, the crew will experience communication delays similar to ones astronauts will face on future missions to Mars and beyond, which could be as long as 20 minutes each way.

Through NASA’s Human Research Program, the crew members will participate in 18 human health studies focused on physiological, behavioral, and psychological health during the mission.

Here's a little more about each of the crew members:

  • As captain engineer for the United Arab Emirates’ Ministry of Defense, Obaid Alsuwaidi, provides guidance in civil and marine engineering and addresses challenges facing the organization.
  • Kristen Magas, an educator and engineer currently teaching at Tri-County Regional Vocational Technical High School in Franklin, Massachusetts, mentors students involved in a NASA design and prototyping program.
  • With more than 20 years of information technology and cybersecurity experience, Tiffany Snyder is a supervisor for the Cybersecurity Mission Integration Office at NASA, helping to ensure agency missions are shielded against cybersecurity threats.
  • Currently researching team resiliency and human-machine interactions, Anderson Wilder is a Florida Institute of Technology graduate student working on his doctorate in Psychology and previously served as an executive officer and engineer for an analog mission at the Mars Desert Research Station in Utah.
  • Jordan Hundley (alternate) is a senior consultant at a professional services firm, offering federal agencies technical and programmatic support.
  • Robert Wilson (alternate) is a senior researcher and project manager at the Johns Hopkins University Applied Physics Laboratory in Laurel, Maryland.

Houston innovator drives EV adoption with unique approach to car leasing, smart tech

HOUSTON INNOVATORS PODCAST EPISODE 258

Switching from a gas-powered car to an electric one can be a big change, but a Houston-based company has made things a lot easier for its customers.

Octopus Electric Vehicles US, a spinout of United Kingdom-based retail energy provider Octopus Energy, matches its users with their perfect EV lease and sets them up with smart electricity technology for at-home charging.

"We do a couple of really unique things that are not only first of its kind but really innovative," Octopus EV's US Co-Lead Chris George says on the Houston Innovators Podcast, pointing out specifically Octopus Energy's Intelligent Octopus, a smart feature for customers that automates energy usage to lower cost.

"We launched an Intelligent Octopus for EVs service. Instead of operating in a very narrow window — overnight — it operates dynamically," he continues.


Pulling from the success of its British EV leasing business, Octopus EV helps Texans find their ideal car to lease from the available pre-owned EVs in the state. The process is hands on, George says, and he and his team are constantly working directly with customers to find them their right make, model, mileage, and more, then setting them up for free home charging with Octopus. All this for as low as $200 a month — perfect for both EV veterans and newbies alike.

"We serve a lot of people. What we're aiming to do is to drive adoption, and we're finding that for most people this is their first EV," George says, explaining that accessibility has been an issue for aspiring EV owners.

The company is rolling out a new process this week. In addition to providing its service in a match-making capacity, now Octopus EV will be showcasing EVs so that customers can browse, test drive, and really get to see what all they like before deciding on a car. George says this new process will be a bit of an experiment.

"We're gong to be showcasing inventory around Houston so customers can see the physical car, the lease price, test drive, and get the car you want," George says. "It's going to look and feel a little different from our current product, but it's going to serve customers just the same."

On the show, George, who previously led EV adoption-focused nonprofit Evolve Houston, shares a bit about the EV industry and what he's closely watching, including growth of charging stations, multifamily charging opportunities, battery technology for EVs and resilience, and perfecting messaging for new and returning customers.

"I'm always trying to think about where are the other things where we can unlock innovation, unlock ideas that help our industry and help Houstonians," George says.