Houston founder taps into AI tech to create game-changing healthy eating platform

there's an app for that

A Better Meal — a new app from a Houston founder — gives you all the tools you need to make healthier food choices. Photo via abettermeal.com

After many years of living to eat, a large swath of American society is now facilitating a seismic shift to the healthier alternative, eating to live.

But here’s the rub: eating healthy is confusing, time consuming and, unfortunately, oftentimes pricey.

So, anyone that can come in and cut through the healthy eating machine can carve out a necessary niche in the marketplace.

Enter Houstonian Mark Semmelbeck, founder and CEO of A Better Meal, a platform created to help busy families plan healthy meals easier and to make gradual improvements to their health and well-being.

“My vision is to use rapidly expanding AI technology together with the knowledge and wisdom of an active community to take the stress out of meal planning and improving nutrition,” says Semmelbeck, a seasoned oil and gas executive with over 30 years of experience in founding companies. “While developing the technology for the app, my daughter gave me two beautiful grandkids who both have significant food allergies. Combine that with the fact I now have five cardiac stents and the significance of eating well while paying attention to the details has only grown in importance.”

All-in-one app

Billed as the one-stop meal planning companion, A Better Meal promises users no additional stress in finding the time to look for recipes, make grocery lists, or prepare meals quickly. Families need healthy options and to be able to provide them with ease and that’s where this new application comes in.

“So, when I started A Better Meal, I wanted to answer two questions or help people answer two questions,” says Semmelbeck. “That is, a family gets home in the evening and they don't want to order out and they don't want to go out to eat, they can open up this app and it can tell them, ‘here's three things that you can make with what you have on hand that you like.’ The other question is, 'how can I make small changes to how I prepare my food, how I cook it, the ingredients that I use and small changes that can make my meals healthier.'

“So that was where we started. And then as we built the app out, got a minimum viable product out to people and in front of them, and we started seeing more as they used the app, what they actually wanted when they went to a meal planning app, so the last year and a half has been a process of refining the app to really set what people want in a meal planning and recipe app.”

When users download the app, which is a subscription-based tool, it starts with the simple things like, how many meals they’d like per day, if they have preferences in the types of food that they like, and, of course, if they have allergies.

Custom experience

Semmelbeck says that users are able to personalize the app and set up their own dashboard with meal planning. You can also use the app to analyze a new recipe you'd like to try.

"You can take a picture of, say a recipe written down, and you'd like to put that in your own personal database, you can take a picture of it, and it will interpret it and bring that into the app and then the app will calculate the calories and macros and the macro nutrients that that meal has in it so that you can see that information also," he says.

When it comes to food and meal planning, inserting the word “healthy” invariably invokes a litany of personal definitions, up to and including weight loss.

That definition isn’t wrong by any means, but for A Better Meal, it’s all about introducing healthier options into people’s everyday lives. The app won’t give you a specific diet to follow, but if users prefer a vegetarian, keto or paleo diet, the app will recommend recipes that will satisfy those disciplines.

“For a lot of people that's a huge help,” says Semmelbeck. “They just want to cook and eat healthier. They may like to have vegetarian days mixed in, but don't know where to find those recipes, the app can suggest recipes for a vegetarian meal. It can also recommend that substituting whole wheat flour for conventional flour for making pancakes, things like that.”

And for those users who don’t necessarily have a planned out starting place for meal preparation, they can search the internet or social media for meal plans and diets and then simply import those into the app.

“We also use AI to analyze recipes that would satisfy a certain type of diet that you would want to participate in,” says Semmelback. “But I will say that one of the main things we want to do is help you make small changes because again diets are great and a lot of people are on them, but few people maintain them for long periods of time because, in general, they can be very restrictive.

“So, we really want our goal to be able to help you make small changes with the things that you like to eat to make them healthier. And again, by healthy, certain kinds of fats are good, others you want to limit, certainly processed foods you want to limit, you want to limit the amount of added sugar, and you want to limit the amount of processed foods. That’s why we have our own nutritionist that helps us with those diets.”

Starting a journey

Currently, the nutritionist for A Better Meal is working just for the app in general, but as the platform grows, users will be about to ask direct questions or at least have access to educational materials about specific health issues, and specific diet recommendations for various health use.

“The app has been live for about a year and early on, we found that what people said they want is much different than what they actually use in the app. So, a lot of our work has been over the past year modifying the app, the way you move around in the app," says Semmelback. "We really want to use AI in ways that are helpful to people.

"I personally have dealt with heart disease, and I know that my doctor recommends less added sugar and processed foods. And so those are the kinds of things that we are using AI to do to help take recipes that you might like and make substitutions to those recipes so that they fit the kind of lifestyle you want," he continues. "What we're really concentrating on is the recipe part of the app and improving those and allowing them to be adaptable to the desires of the users. Finally, we really want to push into more education and more gamification where it actually makes it fun to use the app.”

Many women worry about traveling alone, but having allies can be a game-changer. Photo by Faith D on Unsplash

New app with tips for solo women travelers takes flight from Texas

explore mode activated

We all have that one friend whose office seems to be the nearest airport gate. We go to them for travel advice and hit save on their latest post for that hole-in-the-wall restaurant that had the best local food. That type of advice — especially between women — is indispensable for solo travelers, and now a new travel app based in Austin is helping organize it on a new platform without the social media noise.

Solo travel has gained a lot of momentum in the past few years, and it’s no longer just something one does during a gap year before or after college. It’s become the preferred way to travel for many, and women are at the forefront.

According to Condor Ferries, 72 percent of American women like to take solo trips, and the term “female solo travel” has increased 62 percent over the past three years across all search engines. What if there was a place where women solo travelers could get recommendations and travel itineraries created by other solo women travelers?

This concept is the backbone of Airheart, which aims to revolutionize the travel industry by offering a safe space for solo female travelers to find itineraries and travel guides that were crafted with them in mind.

"Traveling solo as a woman is an empowering act of independence," said Airheart founder Lindsey Renken in a press release. "At Airheart, we celebrate and support this journey, helping women discover new places, connections, and strengths."

The platform includes integrated planning tools, interactive maps, itineraries, and video tips all conveniently located in one place and customizable to the traveler’s preference. Once a user creates an account and accesses the site, the navigation is pretty straightforward.

There’s an explore option at the top of the home screen showcasing all the travel guides available for purchase within the platform, with destinations all over the world. At the moment, most are within the US, Mexico, Western Europe, and Asia. Once the user chooses a guide, a sidebar populates with a list of recommendations or a day-by-day itinerary. The right side of the screen is a map with all the pinned recommendations for easy navigating.

For those wanting to travel more within Texas this summer, Airheart offers a few destinations with a wide range of activities:

  • Big Bend/West Texas: For nature lovers, explore the beautiful mountain desert region of West Texas with a comprehensive guide that includes tips on how to get there and how to choose the best accommodation for your trip — something that becomes more complex in such a remote place.
  • Glen Rose: Escape to this charming small town just an hour-and-a-half Southwest of Dallas-Fort Worth, that is perfect for a weekend getaway full of outdoor adventures. These recommendations come from a local.
  • Fredericksburg: Indulge in the best wineries and restaurants that Central Texas has to offer with an itinerary crafted by a Texas native. This one is ideal for a quick day trip or a fun girls’ weekend.

Airheart, named after the pioneering aviator Amelia Earhart, is also focused on empowering female travel creators by allowing them to act as a type of modern travel agent. They can monetize both new and existing travel content by creating these guides and itineraries, while reaching a new audience on the platform.

“As an avid traveler, I’m always looking for something like this created by expert travelers. I can’t wait to be a seller and consumer,” said Tanna Wasilchak who contributed guides for Waco, Glen Rose, and Georgetown. “Solo traveling as a female can be intimidating at first, but it’s one of the most rewarding experiences I’ve ever had. Airheart is going to be such a game changer for this community.”

Perhaps the only downside for now is that Airheart is limited in what it can offer to its users with only 22 guides published on the site. However, the features and community-based aspect give the platform the potential to stand out in an otherwise saturated market. Guides ($29 each before taxes and fees) are available for users to browse and purchase at airheart.com.

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This article originally ran on CultureMap.

ChewTyme has launched in Houston and Atlanta to approach the fast-growing food delivery industry in a new way. Photo via Getty Images

Houston entrepreneur launches platform for on-demand ordering with biz support for restaurateurs

it's chewtyme

While Ashley Loveless Cunningham has advised clients how to fix bad credit and build a healthy financial life for years, a look at her family’s own spending on food delivery came as a wake-up call.

Like a lot of busy households, they loved to order food through delivery apps, so much so that Cunningham realized it was time for a change. With the delivery charge and other fees that apps like DoorDash and GrubHub tack on, a food order can easily double in price. A $15 bowl from Chipotle that her son liked to order cost almost $40 by the time it got to the house — and that doesn’t even include a tip for the delivery driver.

“I thought, wait a minute. This is ridiculous,” she says.

She says she brainstormed, and began to look into ways to offer an alternative, not only for consumers, but for minority-owned restaurants that were struggling to keep their doors open.

So, Cunningham, whose business ventures include her financial literacy business New Credit Inc. and a perfume line, created her own app, ChewTyme.

The app launched in Houston and Atlanta last Friday, and has drawn over 3,000 consumer downloads, which Cunningham says is a “pretty good” start.

Cunningham, 40, a native of Mobile, Alabama, says she moved to Houston with her family ten months ago, drawn by the opportunity to grow their various businesses. And, the city’s vibrant food scene offered another avenue.

“Everybody moves here to open a restaurant,” she says of Houston.

Extra support on the side

Through restaurant owner clients of her credit counseling business, she learned that many were struggling to remain open. A lot of the business owners aren’t aware of the many options available to them, in business lines of credit, assuming their own personal financial credit is in good shape.

That’s where the business education side of the app comes in, where restaurateurs will gain access to “Business University,” financial guidance for their journey in the industry.

“I tell people, it’s not only about cash funding. There are other resources out there, things we need to thrive in the business space,” she says, adding that this includes mentorship and publicity services.

Many restaurant owners told her they partner with at least two or three food delivery apps already. But she thinks ChewTyme will stand out.

“A lot of people I’ve talked to, they just don’t know where to start,” she says. Her partnership with the restaurants would solve that issue, helping restaurateurs create a “full, state-of-the-art profile” that guides them every step of the way.

While she's yet to onboard her inaugural Houston restaurants, the app has begun to draw interest, Ashley says, especially from entrepreneurs who need a cheaper way to scale their business growth.

Cunningham says ChewTyme offers a competitive alternative to many third-party apps, which she says charge anywhere from a 20-22 percent commission on a restaurant’s delivery orders. The app will charge a 17 percent commission, with no monthly fee, and a flat $4.95 delivery rate to consumers, whom she plans to attract with discounts and promotions.

She hopes to initially sign up 25 restaurants in Houston and the same number in Atlanta, during the beta run of the app. As they work out the kinks, she feels confident in expansion.

Her biggest challenge moving forward is hiring quality drivers, she says.

“That really scares me. People who want to work, who have integrity. I’ve heard horror stories because people literally pick up their food and don’t deliver it,” she says.

ChewTyme is working with contracting partners who are conducting screening and background checks for potential drivers, and onboarding restaurant owners with follow-up. Interested restaurateurs or drivers can request more information on ChewTyme's website.

Tapping into a high-growth market

Third-party food delivery exploded in popularity during the pandemic, and a 2021 McKinsey report found that food delivery more than tripled since 2017. Post-pandemic, the on-demand services industry growth hasn't waned.

The Texas Restaurant Association fought for a law passed in 2021 to prevent third-party apps from adding restaurants to a delivery platform without a financial agreement or partnership, according to Christine Robbins, executive director of the association. But now that relationship seems to have settled into a profitable venture on both sides.

Taj Walker, of H-Town Restaurant Group, which owns Hugo’s, Xochi, and six other local restaurants, says the apps don’t typically charge a fee unless the restaurant takes part in an app’s ad promotion of their restaurant.

An app’s commission can range from 10 to 25 percent, he says, which their restaurants compensate for by charging 10 percent more on app orders than in-house food. The apps have become an important revenue stream for some H-Town’s more casual eateries, especially Urbe and Prego, which are popular among younger clientele, Walker says.

While Cunningham’s main goal is to uplift minority entrepreneurs and communities, the app will be available to any restaurateur who wants it.

Since expanding to Houston, this innovative European company has saved nearly 30,000 meals from being wasted. Photo via toogoodtogo.com

European app expands to Houston, partners with local vendors to combat food waste

sustainable impact

Since expanding into Houston just over two months ago, an app that combats food waste has saved over 28,000 meals.

By partnering with locally owned vendors like the Village Bakery, as well as larger chains like Tiff’s Treats, Too Good To Go offers Houstonians a variety of discounted goodies. Users can browse a range of stores and sign up for a “surprise bag,” an assemblage of surplus food that typically costs $5.

The free mobile app now connects savvy shoppers to 130 Houston area stores, allowing them to enjoy food that would otherwise be thrown away. Based in Denmark, Too Good To Go previously launched in Texas in Austin in 2021, before its statewide expansion into Dallas, Houston, and San Antonio in July.

"We are excited to expand our app across Texas to partner with the dynamic food scene and culture," says Chris MacAulay, Too Good To Go US Country Director, in a press release. "In partnership with the incredible local food businesses across Texas, we want to make reducing food waste accessible to all. Together, with the great restaurant community and residents in Texas, we know we will have an immediate impact."

Sarah Soteroff, senior PR manager of Too Good To Go’s North American branch, shared the European based corporation’s scaling up of operations in Texas is part of their plan to move across the United States, going into more cities where food waste persists.

“Our goal is to reduce food waste everywhere that it occurs. So in the long term, we want to eliminate food waste globally,” Soteroff says.

The move into U.S. cities has been gradual, as Soteroff said Too Good To Go works to get an initial network of 50 businesses signed up for the app before officially launching. Beyond getting vendors to list their surplus stock on the app, Too Good To Go representatives aid in marketing and educating the stores on how to use the app.

“We want to make sure that we are setting those businesses up for success and ensuring that consumers know about it through PR, through the stories we share. That businesses do feel as though there’s a value to them for being on the app,” Soteroff explains.

Though the surprise bags are typically priced at about one-third their retail values, vendors can still bring in business through these mystery deals. Roughly 8,500 unique users in Houston have made purchases through the app since it debuted, preventing over 28,000 meals from ending up in landfills.

“For us to ensure that we are able to reduce food waste, we do have to be going into markets like Houston, Dallas, San Antonio, and Austin–in those larger cities where there’s a larger concentration of stores,” Soteroff shares.

According to the Too Good To Go website, every surprise bag purchased prevents the “CO2e emission of charging one smartphone fully 422 times,” and in 2022 the company averted nearly 200,000 tons of CO2e emissions through its community partnerships.

The myAvos app has been designed by behavioral health scientists to set users up for long, healthy lives. Photo via Canva

Houston innovator launches holistic health and cognitive care app

download now

Meet Laura. She’s not human, but she could be the key to your aging healthfully. She’s the digital wellness coach on myAvos, a groundbreaking app that launched this week from OptiChroniX.

Now meet Le Dam, the woman behind the app. Dam is a medical doctor, as well as CEO and co-founder of OptiChroniX. While practicing medicine in her birthplace of Australia, Dam realized that her life of prescribing medications to patients who were already sick was not how she had envisioned helping people. She knew that prevention, using the five pillars of healthy aging — nutrition, activity, sleep, health, and stress — was the way to keep patients fit and happy into their golden years.

She returned to California, where she lived after leaving Houston as a youth, to work at a startup with the goal of one day heading a company of her own. She met Swiss-based COO and co-founder, Rene Gilvert, on LinkedIn.

“He was looking for a medical doctor to join his startup,” Dam recalls. “We were so well aligned that we decided to join forces.” Now, the team works remotely in locations ranging from Dam’s home in Houston to Portugal.

When the pandemic happened, Dam took the opportunity to leave the Silicon Valley and work remotely from Houston, a return that she says was always her end goal.

“I always knew that I wanted to build my business in Houston,” Dam says, mentioning the assets of the world’s largest medical center, a thriving startup community, and diverse population for whom she wants to build her technology.

myAvos pairs with a user’s smart watch and harnesses their health information such as physical activity and hours slept. The user can also input additional information such as blood test results and meals eaten. The app analyzes the information provided and assesses the user’s risk for chronic illness later in life. From there, Laura coaches them on what changes they can make to live healthier lifestyles. The app even reminds users when to take their medications and shares information with designated caregivers.

The myAvos app has a comprehensive approach to health. Screenshots via avos.health

The app has been designed by behavioral health scientists to understand why you’re not exercising enough or eating right and can offer personalized motivations to get users off the couch.

Right now, the focus is on potential dementia and cognitive impairment, says Dam, but in the future, myAvos will more holistically target all preventable chronic illnesses. But dementia is one of the major causes of disability among older people around the world and people living with it is expected to triple by 2050.

“If we can empower people with health literacy, we really believe we can prevent chronic disease,” says Dam. “Forty percent of dementia is preventable. A lot of these chronic diseases are preventable. Even diabetes can be reversible.”

And she points out that the changes that can be made to help cognitive health can affect other systems as well.

“We really want to empower the individuals,” Dam says. “If we can empower people with health literacy, we really believe we can prevent chronic disease.”

And myAvos is the key. The app is based on a subscription model, allowing users full access to a risk calculator, monthly cognitive assessments, personalized lifestyle guidance, and even fun brain games to keep them sharp. It may turn out that a visit with Laura a day will keep the doctor away long into your later years.

Le Dam moved from California to Houston to build her company. Photo via LinkedIn

Aaron Knape joins the Houston Innovators Podcast to share how he's taking the sEATz platform into a new vertical. Photo courtesy of sEATz

Houston sportstech startup scales, plans expansion into health care

HOUSTON INNOVATORS PODCAST EPISODE 109

When sEATz launched, the startup was looking to provide a way for sports fans to order their beer and hotdog to their seat without having to miss a moment of a game. Over the years, the Houston company has expanded its technology to be a reliable platform for mobile order management in stadiums and arenas — and now Aaron Knape, co-founder and CEO, knows the technology can do so much more.

"We started this company with a focus on mobile ordering for sports and entertainment venues," Knape says on this week's episode of the Houston Innovators Podcast. "We've always known we wanted to get into other industry verticals, and one that stuck out, primarily because it's such a big deal in Houston, is the health care industry."

Knape says he and his co-founder, Marshall Law, let this idea be known to their vendor partners, and eventually sEATz got the right connection to a health care campus to try out a new product: MyEatz.

"What we're building now is a mobile ordering platform for these large health care campuses," Knape says, explaining that the campuses have thousands of employees with limited space and time for dining. "We're starting on our first pilots in the health care industry where we provide that mobile ordering platform and back-end support with our partner Aramark."

Among the first groups to pilot the new product is Houston Methodist, Knape says. The pilots should launch this quarter — either this month or next.

"This could be a much bigger market than sports and entertainment," Knape says. "Sports will continue to be our core market, but this will be a little less seasonal."

And, in light of the last 18 months, less averse to the effects of a shutdown of sports and entertainment. However, the sEATz team entered the COVID-19 pandemic with uncertainty — like most of the world — but the team was able to market sEATz mobile ordering platform as something crucial to bringing back fans in stadiums.

"Our goal was to go out and market ourselves and push the branding of 'we facilitate social distancing, mitigate crowds, and get rid of lines,'" Knape says on the show. "That really resonated with a lot of our clientbase."

Remarkably, sEATz even raised fresh funding amid the pandemic. In November of 2020, the startup closed an oversubscribed $1.6 million seed round led by Valedor Partners. Knape says he's currently focused on the company's to support scaling and growing the team by six or so new employees over the next few months.

"I tell the team that we're kind of coming out of stealth mode — I know we're not in a true stealth mode, but we haven't spent a lot of money on sales and marketing," Knape says. "Now it's time to start putting that emphasis on who we are, that we're here, and we're ready to take over."

Knape shares more on how sEATz is growing and the potential for Houston to build a sportstech niche within the innovation ecosystem on the podcast. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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