Houston's Intuitive Machines aims to launch a lander in mid-February, hopping a flight with SpaceX. Photo via intuitivemachines.com

China and India scored moon landings, while Russia, Japan and Israel ended up in the lunar trash heap. Now two private companies are hustling to get the U.S. back in the game, more than five decades after the Apollo program ended — and one is based in Space City Houston.

It’s part of a NASA-supported effort to kick-start commercial moon deliveries, as the space agency focuses on getting astronauts back there.

“They’re scouts going to the moon ahead of us," said NASA Administrator Bill Nelson.

Pittsburgh's Astrobotic Technology is up first with a planned liftoff of a lander today aboard a brand new rocket, United Launch Alliance’s Vulcan. Houston's Intuitive Machines aims to launch a lander in mid-February, hopping a flight with SpaceX.

Then there's Japan, which will attempt to land in two weeks. The Japanese Space Agency’s lander with two toy-size rovers had a big head start, sharing a September launch with an X-ray telescope that stayed behind in orbit around Earth.

If successful, Japan will become the fifth country to pull off a lunar landing. Russia and the U.S. did it repeatedly in the 1960s and 70s. China has landed three times in the past decade — including on the moon’s far side — and is returning to the far side later this year to bring back lunar samples. And just last summer, India did it. Only the U.S. has put astronauts on the moon.

Landing without wrecking is no easy feat. There's hardly any atmosphere to slow spacecraft, and parachutes obviously won't work. That means a lander must descend using thrusters, while navigating past treacherous cliffs and craters.

A Japanese millionaire’s company, ispace, saw its lander smash into the moon last April, followed by Russia’s crash landing in August. India triumphed a few days later near the south polar region; it was the country’s second try after crashing in 2019. An Israeli nonprofit also slammed into the moon in 2019.

The United States has not attempted a moon landing since Apollo 17’s Gene Cernan and Harrison Schmitt, the last of 12 moonwalkers, explored the gray, dusty surface in December 1972. Mars beckoned and the moon receded in NASA's rearview mirror, as the space race between the U.S. and the Soviet Union came to a close. The U.S. followed with a handful or two of lunar satellites, but no controlled landers — until now.

Not only are Astrobotic and Intuitive Machines looking to end America’s moon-landing drought, they’re vying for bragging rights as the first private entity to land — gently — on the moon.

Despite its later start, Intuitive Machines has a faster, more direct shot and should land within a week of liftoff. It will take Astrobotic two weeks just to get to the moon and another month in lunar orbit, before a landing is attempted on Feb. 23.

If there are rocket delays, which already have stalled both missions, either company could wind up there first.

“It’s going to be a wild, wild ride,” promised Astrobotic’s chief executive John Thornton.

His counterpart at Intuitive Machines, Steve Altemus, said the space race is "more about the geopolitics, where China is going, where the rest of the world’s going.” That said, “We sure would like to be first.”

The two companies have been nose to nose since receiving nearly $80 million each in 2019 under a NASA program to develop lunar delivery services. Fourteen companies are now under contract by NASA.

Astrobotic’s four-legged, 6-foot-tall (1.9-meter-tall) lander, named Peregrine after the fastest bird, a falcon, will carry 20 research packages to the moon for seven countries, including five for NASA and a shoebox-sized rover for Carnegie Mellon University. Peregrine will aim for the mid-latitudes' Sinus Viscositatis, or Bay of Stickiness, named after the long-ago silica magma that formed the nearby Gruithuisen Domes.

Intuitive Machines’ six-legged, 14-foot-tall (4-meter-tall) lander, Nova-C, will target the moon’s south polar region, also carrying five experiments for NASA that will last about two weeks. The company is targeting 80 degrees south latitude for touchdown. That would be well within Antarctica on Earth, Altemus noted, and 10 degrees closer to the pole than India landed last summer.

Scientists believe the south pole’s permanently shadowed craters hold billions of pounds (kilograms) of frozen water that could be used for drinking and making rocket fuel. That’s why the first moonwalkers in NASA’s Artemis program — named after Apollo’s twin sister in Greek mythology — will land there. NASA still has 2025 on the books for that launch, but the General Accountability Office suspects it will be closer to 2027.

Astrobotic will head to the south pole on its second flight, carrying NASA’s water-seeking Viper rover. And Intuitive Machines will return there on its second mission, delivering an ice drill for NASA.

Landing near the moon’s south pole is particularly dicey.

“It’s so rocky and craggy and full of craters at the south pole and mountainous, that it’s very difficult to find a lighted region to touch down safely," Altemus said. "So you’ve got to be able to finesse that and just set it down right in the right spot.”

While Houston has long been associated with space, Pittsburgh is a newcomer. To commemorate the Steel City, Astrobotic’s lander will carry a Kennywood amusement park token, the winner of a public vote that beat out the Steelers’ Terrible Towel waved at football games, dirt from Moon Township’s Moon Park, and a Heinz pickle pin.

The lander is also carrying the ashes or DNA from 70 people, including “Star Trek” creator Gene Roddenberry and science fiction writer Arthur C. Clarke. Another 265 people will be represented on the rocket’s upper stage, which will circle the sun once separated from the lander. They include three original “Star Trek” cast members, as well as strands of hair from three U.S. presidents: George Washington, Dwight D. Eisenhower and John F. Kennedy.

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Autonomous truck company with Houston routes goes public

on a roll

Kodiak Robotics, a provider of AI-powered autonomous vehicle technology, has gone public through a SPAC merger and has rebranded as Kodiak AI. The company operates trucking routes to and from Houston, which has served as a launchpad for the business.

Privately held Kodiak, founded in 2018, merged with a special purpose acquisition company — publicly held Ares Acquisition Corp. II — to form Kodiak AI, whose stock now trades on the Nasdaq market.

In September, Mountain View, California-based Kodiak and New York City-based Ares disclosed a $145 million PIPE (private investment in public equity) investment from institutional investors to support the business combo. Since announcing the SPAC deal, more than $220 million has been raised for the new Kodiak.

“We believe these additional investments underscore our investors’ confidence in the value proposition of Kodiak’s safe and commercially deployed autonomous technology,” Don Burnette, founder and CEO of Kodiak, said in a news release.

“We look forward to leading the advancement of the commercial trucking and public sector industries,” he added, “and delivering on the exciting value creation opportunities ahead to the benefit of customers and shareholders.”

Last December, Kodiak debuted a facility near George Bush Intercontinental/Houston Airport for loading and loading driverless trucks. Transportation and logistics company Ryder operates the “truckport” for Ryder.

The facility serves freight routes to and from Houston, Dallas and Oklahoma City. Kodiak’s trucks currently operate with or without drivers. Kodiak’s inaugural route launched in 2024 between Houston and Dallas.

One of the companies using Kodiak’s technology is Austin-based Atlas Energy Solutions, which owns and operates four driverless trucks equipped with Kodiak’s driver-as-a-service technology. The trucks pick up fracking sand from Atlas’ Dune Express, a 42-mile conveyor system that carries sand from Atlas’ mine to sites near customers’ oil wells in the Permian Basin.

Altogether, Atlas has ordered 100 trucks that will run on Kodiak’s autonomous technology in an effort to automate Atlas’ supply chain.

Rice University scientists invent new algorithm to fight Alzheimer's

A Seismic Breakthrough

A new breakthrough from researchers at Rice University could unlock the genetic components that determine several human diseases such as Parkinson's and Alzheimer's.

Alzheimer's disease affected 57 million people worldwide in 2021, and cases in the United States are expected to double in the next couple of decades. Despite its prevalence and widespread attention of the condition, the full mechanisms are still poorly understood. One hurdle has been identifying which brain cells are linked to the disease.

For years, it was thought that the cells most linked with Alzheimer's pathology via DNA evidence were microglia, infection-fighting cells in the brain. However, this did not match with actual studies of Alzheimer's patients' brains. It's the memory-making cells in the human brain that are implicated in the pathology.

To prove this link, researchers at Rice, alongside Boston University, developed a computational algorithm called “Single-cell Expression Integration System for Mapping Genetically Implicated Cell Types," or SEISMIC. It allows researchers to zero in on specific neurons linked to Alzheimer's, the first of its kind. Qiliang Lai, a Rice doctoral student and the lead author of a paper on the discovery published in Nature Communications, believes that this is an important step in the fight against Alzheimer's.

“As we age, some brain cells naturally slow down, but in dementia — a memory-loss disease — specific brain cells actually die and can’t be replaced,” said Lai. “The fact that it is memory-making brain cells dying and not infection-fighting brain cells raises this confusing puzzle where DNA evidence and brain evidence don’t match up.”

Studying Alzheimer's has been hampered by the limitations of computational analysis. Genome-wide association studies (GWAS) and single-cell RNA sequencing (scRNA-seq) map small differences in the DNA of Alzheimer's patients. The genetic signal in these studies would often over-emphasize the presence of infection fighting cells, essentially making the activity of those cells too "loud" statistically to identify other factors. Combined with greater specificity in brain regional activity, SEISMIC reduces the data chatter to grant a clearer picture of the genetic component of Alzheimer's.

“We built our SEISMIC algorithm to analyze genetic information and match it precisely to specific types of brain cells,” Lai said. “This enables us to create a more detailed picture of which cell types are affected by which genetic programs.”

Though the algorithm is not in and of itself likely to lead to a cure or treatment for Alzheimer's any time soon, the researchers say that SEISMIC is already performing significantly better than existing tools at identifying important disease-relevant cellular signals more clearly.

“We think this work could help reconcile some contradicting patterns in the data pertaining to Alzheimer’s research,” said Vicky Yao, assistant professor of computer science and a member of the Ken Kennedy Institute at Rice. “Beyond that, the method will likely be broadly valuable to help us better understand which cell types are relevant in different complex diseases.”

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This article originally appeared on CultureMap.com.

5 incubators and accelerators fueling the growth of Houston startups

meet the finalists

Houston is home to numerous accelerators and incubators that support founders in pushing their innovative startups and technologies forward.

As part of our 2025 Houston Innovation Awards, the new Incubator/Accelerator of the Year category honors a local incubator or accelerator that is championing and fueling the growth of Houston startups.

Five incubators and accelerators have been named finalists for the 2025 award. They support startups ranging from hard-tech companies to digital health startups.

Read more about these organizations below. Then join us at the Houston Innovation Awards on Nov. 13 at Greentown Labs, when the winner will be unveiled.

Get your tickets now on sale for this exclusive event celebrating Houston Innovation.

Activate

Hard tech incubator Activate supports scientists in "the outset of their entrepreneurial journey." The Houston hub was introduced last year, and joins others in Boston, New York, and Berkley, California—where Activate is headquartered. It named its second Houston cohort this summer.

This year, the incubator grew to include its largest number of concurrent supported fellows, with 88 companies currently being supported nationally. In total, Activate has supported 296 fellows who have created 236 companies. Those companies have raised over $4 billion in follow-on funding, according to Activate. In Houston, it has supported several Innovation Awards finalists, including Solidec, Bairitone Health and Deep Anchor Solutions. It is led locally by Houston Managing Director Jeremy Pitts.

EnergyTech Nexus

Cleantech startup hub EnergyTech Nexus' mission is to accelerate the energy transition by connecting founders, investors and industrial stakeholders and helping to develop transformative companies, known as "thunderlizards."

The hub was founded in 2023 by CEO Jason Ethier, Juliana Garaizar and Nada Ahmed. It has supported startups including Capwell Services, Resollant, Syzygy Plasmonics, Hertha Metals, EarthEn Energy and Solidec—many of which are current or past Innovation Awards finalists. This year Energy Tech Nexus launched its COPILOT Accelerator, powered by Wells Fargo Innovation Incubator (IN²) at the National Renewable Energy Laboratory (NREL). COPILOT partners with Browning the Green Space, a nonprofit that promotes diversity, equity and inclusion (DEI) in the clean energy and climatech sectors. Energy Tech Nexus also launched its Liftoff fundraising program, its Investor Program, and a "strategic ecosystem partnership" with Greentown Labs.

Greentown Labs

Climatetech incubator Greentown Labs offers its community resources and a network to climate and energy innovation startups looking to grow. The collaborative community offers members state-of-the-art prototyping labs, business resources and access to investors and corporate partners. The co-located incubator was first launched in Boston in 2011 before opening in Houston in 2021.

Greentown has seen major changes and activity this year. In February, Greentown announced Georgina Campbell Flatter as its new CEO, along with a new Board of Directors. In July, it announced Lawson Gow as its Head of Houston, a "dedicated role to champion the success of Greentown Houston’s startups and lead Greentown’s next chapter of impact in the region," according to Greentown. It has since announced numerous new partnerships, including those with Energy Tech Nexus, Los Angeles-based software development firm Nominal, to launch the new Industrial Center of Excellence; and Houston-based Shoreless, to launch an AI lab onsite. Greentown Houston has supported 175 startups since its launch in 2021, with 45 joining in the last two years. Those startups include the likes of Hertha Metals, RepAir Carbon, Solidec, Eclipse Energy (formerly GoldH2) and many others.

Healthtech Accelerator (TMCi)

The Healthtech Accelerator, formerly TMCx, focuses on clinical partnerships to improve healthcare delivery and outcomes. Emerging digital health and medical device startups that join the accelerator are connected with a network of TMC hospitals and seasoned advisors that will prepare them for clinical validation, funding and deployment.

The Healthtech Accelerator is part of Texas Medical Center Innovation, which also offers the TMCi Accelerator for Cancer Therapeutics. The Healthtech Accelerator named its 19th, and latest, cohort of 11 companies last month.

Impact Hub Houston

Impact Hub Houston supports early-stage ventures at various stages of development through innovative programs that address pressing societal issues. The nonprofit organization supports social impact startups through mentorship, connections and training opportunities.

There are more than 110 Impact Hubs globally with 24,000-plus members spanning 69 countries, making it one of the world’s largest communities for accelerating entrepreneurial solutions toward the United Nations' Sustainable Development Goals (SDGs).

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The Houston Innovation Awards program is sponsored by Houston City College Northwest, Houston Powder Coaters, FLIGHT by Yuengling, and more to be announced soon. For sponsorship opportunities, please contact sales@innovationmap.com.