Houston's Intuitive Machines aims to launch a lander in mid-February, hopping a flight with SpaceX. Photo via intuitivemachines.com

China and India scored moon landings, while Russia, Japan and Israel ended up in the lunar trash heap. Now two private companies are hustling to get the U.S. back in the game, more than five decades after the Apollo program ended — and one is based in Space City Houston.

It’s part of a NASA-supported effort to kick-start commercial moon deliveries, as the space agency focuses on getting astronauts back there.

“They’re scouts going to the moon ahead of us," said NASA Administrator Bill Nelson.

Pittsburgh's Astrobotic Technology is up first with a planned liftoff of a lander today aboard a brand new rocket, United Launch Alliance’s Vulcan. Houston's Intuitive Machines aims to launch a lander in mid-February, hopping a flight with SpaceX.

Then there's Japan, which will attempt to land in two weeks. The Japanese Space Agency’s lander with two toy-size rovers had a big head start, sharing a September launch with an X-ray telescope that stayed behind in orbit around Earth.

If successful, Japan will become the fifth country to pull off a lunar landing. Russia and the U.S. did it repeatedly in the 1960s and 70s. China has landed three times in the past decade — including on the moon’s far side — and is returning to the far side later this year to bring back lunar samples. And just last summer, India did it. Only the U.S. has put astronauts on the moon.

Landing without wrecking is no easy feat. There's hardly any atmosphere to slow spacecraft, and parachutes obviously won't work. That means a lander must descend using thrusters, while navigating past treacherous cliffs and craters.

A Japanese millionaire’s company, ispace, saw its lander smash into the moon last April, followed by Russia’s crash landing in August. India triumphed a few days later near the south polar region; it was the country’s second try after crashing in 2019. An Israeli nonprofit also slammed into the moon in 2019.

The United States has not attempted a moon landing since Apollo 17’s Gene Cernan and Harrison Schmitt, the last of 12 moonwalkers, explored the gray, dusty surface in December 1972. Mars beckoned and the moon receded in NASA's rearview mirror, as the space race between the U.S. and the Soviet Union came to a close. The U.S. followed with a handful or two of lunar satellites, but no controlled landers — until now.

Not only are Astrobotic and Intuitive Machines looking to end America’s moon-landing drought, they’re vying for bragging rights as the first private entity to land — gently — on the moon.

Despite its later start, Intuitive Machines has a faster, more direct shot and should land within a week of liftoff. It will take Astrobotic two weeks just to get to the moon and another month in lunar orbit, before a landing is attempted on Feb. 23.

If there are rocket delays, which already have stalled both missions, either company could wind up there first.

“It’s going to be a wild, wild ride,” promised Astrobotic’s chief executive John Thornton.

His counterpart at Intuitive Machines, Steve Altemus, said the space race is "more about the geopolitics, where China is going, where the rest of the world’s going.” That said, “We sure would like to be first.”

The two companies have been nose to nose since receiving nearly $80 million each in 2019 under a NASA program to develop lunar delivery services. Fourteen companies are now under contract by NASA.

Astrobotic’s four-legged, 6-foot-tall (1.9-meter-tall) lander, named Peregrine after the fastest bird, a falcon, will carry 20 research packages to the moon for seven countries, including five for NASA and a shoebox-sized rover for Carnegie Mellon University. Peregrine will aim for the mid-latitudes' Sinus Viscositatis, or Bay of Stickiness, named after the long-ago silica magma that formed the nearby Gruithuisen Domes.

Intuitive Machines’ six-legged, 14-foot-tall (4-meter-tall) lander, Nova-C, will target the moon’s south polar region, also carrying five experiments for NASA that will last about two weeks. The company is targeting 80 degrees south latitude for touchdown. That would be well within Antarctica on Earth, Altemus noted, and 10 degrees closer to the pole than India landed last summer.

Scientists believe the south pole’s permanently shadowed craters hold billions of pounds (kilograms) of frozen water that could be used for drinking and making rocket fuel. That’s why the first moonwalkers in NASA’s Artemis program — named after Apollo’s twin sister in Greek mythology — will land there. NASA still has 2025 on the books for that launch, but the General Accountability Office suspects it will be closer to 2027.

Astrobotic will head to the south pole on its second flight, carrying NASA’s water-seeking Viper rover. And Intuitive Machines will return there on its second mission, delivering an ice drill for NASA.

Landing near the moon’s south pole is particularly dicey.

“It’s so rocky and craggy and full of craters at the south pole and mountainous, that it’s very difficult to find a lighted region to touch down safely," Altemus said. "So you’ve got to be able to finesse that and just set it down right in the right spot.”

While Houston has long been associated with space, Pittsburgh is a newcomer. To commemorate the Steel City, Astrobotic’s lander will carry a Kennywood amusement park token, the winner of a public vote that beat out the Steelers’ Terrible Towel waved at football games, dirt from Moon Township’s Moon Park, and a Heinz pickle pin.

The lander is also carrying the ashes or DNA from 70 people, including “Star Trek” creator Gene Roddenberry and science fiction writer Arthur C. Clarke. Another 265 people will be represented on the rocket’s upper stage, which will circle the sun once separated from the lander. They include three original “Star Trek” cast members, as well as strands of hair from three U.S. presidents: George Washington, Dwight D. Eisenhower and John F. Kennedy.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”