Houston's Intuitive Machines aims to launch a lander in mid-February, hopping a flight with SpaceX. Photo via intuitivemachines.com

China and India scored moon landings, while Russia, Japan and Israel ended up in the lunar trash heap. Now two private companies are hustling to get the U.S. back in the game, more than five decades after the Apollo program ended — and one is based in Space City Houston.

It’s part of a NASA-supported effort to kick-start commercial moon deliveries, as the space agency focuses on getting astronauts back there.

“They’re scouts going to the moon ahead of us," said NASA Administrator Bill Nelson.

Pittsburgh's Astrobotic Technology is up first with a planned liftoff of a lander today aboard a brand new rocket, United Launch Alliance’s Vulcan. Houston's Intuitive Machines aims to launch a lander in mid-February, hopping a flight with SpaceX.

Then there's Japan, which will attempt to land in two weeks. The Japanese Space Agency’s lander with two toy-size rovers had a big head start, sharing a September launch with an X-ray telescope that stayed behind in orbit around Earth.

If successful, Japan will become the fifth country to pull off a lunar landing. Russia and the U.S. did it repeatedly in the 1960s and 70s. China has landed three times in the past decade — including on the moon’s far side — and is returning to the far side later this year to bring back lunar samples. And just last summer, India did it. Only the U.S. has put astronauts on the moon.

Landing without wrecking is no easy feat. There's hardly any atmosphere to slow spacecraft, and parachutes obviously won't work. That means a lander must descend using thrusters, while navigating past treacherous cliffs and craters.

A Japanese millionaire’s company, ispace, saw its lander smash into the moon last April, followed by Russia’s crash landing in August. India triumphed a few days later near the south polar region; it was the country’s second try after crashing in 2019. An Israeli nonprofit also slammed into the moon in 2019.

The United States has not attempted a moon landing since Apollo 17’s Gene Cernan and Harrison Schmitt, the last of 12 moonwalkers, explored the gray, dusty surface in December 1972. Mars beckoned and the moon receded in NASA's rearview mirror, as the space race between the U.S. and the Soviet Union came to a close. The U.S. followed with a handful or two of lunar satellites, but no controlled landers — until now.

Not only are Astrobotic and Intuitive Machines looking to end America’s moon-landing drought, they’re vying for bragging rights as the first private entity to land — gently — on the moon.

Despite its later start, Intuitive Machines has a faster, more direct shot and should land within a week of liftoff. It will take Astrobotic two weeks just to get to the moon and another month in lunar orbit, before a landing is attempted on Feb. 23.

If there are rocket delays, which already have stalled both missions, either company could wind up there first.

“It’s going to be a wild, wild ride,” promised Astrobotic’s chief executive John Thornton.

His counterpart at Intuitive Machines, Steve Altemus, said the space race is "more about the geopolitics, where China is going, where the rest of the world’s going.” That said, “We sure would like to be first.”

The two companies have been nose to nose since receiving nearly $80 million each in 2019 under a NASA program to develop lunar delivery services. Fourteen companies are now under contract by NASA.

Astrobotic’s four-legged, 6-foot-tall (1.9-meter-tall) lander, named Peregrine after the fastest bird, a falcon, will carry 20 research packages to the moon for seven countries, including five for NASA and a shoebox-sized rover for Carnegie Mellon University. Peregrine will aim for the mid-latitudes' Sinus Viscositatis, or Bay of Stickiness, named after the long-ago silica magma that formed the nearby Gruithuisen Domes.

Intuitive Machines’ six-legged, 14-foot-tall (4-meter-tall) lander, Nova-C, will target the moon’s south polar region, also carrying five experiments for NASA that will last about two weeks. The company is targeting 80 degrees south latitude for touchdown. That would be well within Antarctica on Earth, Altemus noted, and 10 degrees closer to the pole than India landed last summer.

Scientists believe the south pole’s permanently shadowed craters hold billions of pounds (kilograms) of frozen water that could be used for drinking and making rocket fuel. That’s why the first moonwalkers in NASA’s Artemis program — named after Apollo’s twin sister in Greek mythology — will land there. NASA still has 2025 on the books for that launch, but the General Accountability Office suspects it will be closer to 2027.

Astrobotic will head to the south pole on its second flight, carrying NASA’s water-seeking Viper rover. And Intuitive Machines will return there on its second mission, delivering an ice drill for NASA.

Landing near the moon’s south pole is particularly dicey.

“It’s so rocky and craggy and full of craters at the south pole and mountainous, that it’s very difficult to find a lighted region to touch down safely," Altemus said. "So you’ve got to be able to finesse that and just set it down right in the right spot.”

While Houston has long been associated with space, Pittsburgh is a newcomer. To commemorate the Steel City, Astrobotic’s lander will carry a Kennywood amusement park token, the winner of a public vote that beat out the Steelers’ Terrible Towel waved at football games, dirt from Moon Township’s Moon Park, and a Heinz pickle pin.

The lander is also carrying the ashes or DNA from 70 people, including “Star Trek” creator Gene Roddenberry and science fiction writer Arthur C. Clarke. Another 265 people will be represented on the rocket’s upper stage, which will circle the sun once separated from the lander. They include three original “Star Trek” cast members, as well as strands of hair from three U.S. presidents: George Washington, Dwight D. Eisenhower and John F. Kennedy.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."