The new supercomputer is expected to be one of the world’s most powerful owned by an enterprise. Photo courtesy of HPE

A Houston tech company is building a next-generation supercomputer for one of the world’s largest energy providers.

Hewlett Packard Enterprise announced its plans to build HPC6 for Italian energy company Eni. Eni will use the system to advance scientific discovery and engineering toward accelerating innovation in energy transition to help aid its goal in getting to net zero. HPC6 is expected to be one of the world’s most powerful supercomputers owned by an enterprise.

HPC6 will be built with the same innovations that power the world’s fastest supercomputer to support data and image-intensive workloads across artificial intelligence, modeling, and simulation. According to a news release from HPE, the system will “augment Eni’s existing research that is focused on studying and identifying new energy sources, including renewable energy.”

Eni’s HPC6 will be installed in the company’s energy Green Data Center in Italy. The center will be upgraded to support HPE’s direct liquid-cooling (DLC) capabilities.

"Businesses are finding themselves balancing the huge business opportunities enabled by their AI investments with the responsibility of mitigating the environmental impact of these powerful systems," Antonio Neri, president and CEO of HPE, says in a news release.

"As the leader in developing energy efficient AI and supercomputing solutions, HPE is uniquely positioned to help organizations minimize power consumption while maximizing business outcomes," he continues. "We are excited to play a role in Eni’s commitment to decarbonization supported by digitalization and innovation."

Originally announced in 2020, HPE moved its headquarters to Houston in 2022.

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This article originally ran on EnergyCapital.

The transaction, which was approved by both companies' boards, is expected to close either later this year or early next year. Photo courtesy of HPE

Houston-based HPE to acquire cloud infrastructure co. in $14B deal

M&A moves

Hewlett Packard Enterprise is buying Juniper Networks in an all-cash deal valued at about $14 billion, which is anticipated to double HPE's networking business.

Shares of both companies rose before the market open on Wednesday. A Wall Street Journal report about a potential deal saw Juniper's stock surge 22 percent and HPE's stock dip 9 percent before an official announcement was made.

HPE will pay $40 per Juniper share.

Juniper, based in Sunnyvale, California, helps companies access the cloud infrastructure that serves as the foundation of digital and AI strategies.

“This transaction will strengthen HPE’s position at the nexus of accelerating macro-AI trends, expand our total addressable market, and drive further innovation for customers as we help bridge the AI-native and cloud-native worlds, while also generating significant value for shareholders," HPE President and CEO Antonio Neri said late Tuesday in a statement.

Juniper CEO Rami Rahim will lead the combined HPE networking business. He will report to Neri. HPE was spun off from Hewlett-Packard, one of the founding companies of Silicon Valley, in 2015 and is now based in Houston.

The transaction, which was approved by both companies' boards, is expected to close either later this year or early next year. It still needs approval from Juniper shareholders and regulators.

Last March, HPE announced its plans to acquire OpsRamp, a software-as-a-service company with an IT operations management, or ITOM, platform that can monitor, automate, and manage IT infrastructure, cloud resources, and more.

Hewlett Packard Enterprise's new Houston-area facility will open in 2022. Photo courtesy of HPE/GHP

Tech giant Hewlett Packard Enterprise taps Houston area for global headquarters relocation

here comes HPE

Thousands of potential jobs are coming to the Bayou City region with a major move by a Fortune 500 company. Hewlett Packard Enterprise (HPE) and Texas Gov. Greg Abbott have announced that HPE will relocate its global headquarters to Spring, Texas from San Jose, California.

The headquarters will be located in a new state-of-the-art campus that will open in early 2022, and will build on the company's established presence in the state of Texas, according to a press release. The new campus, being built in the 60-acre Springwoods Village development, will consist of two five-story buildings with some 440,000 square feet of combined space. HPE already boasts a significant footprint in the Houston region, with more than 2,600 area employees, the Greater Houston Partnership notes.

HPE cited Houston's diverse talent base and low cost of doing business as key factors driving the move to the digital tech hub and global headquarters city.

A global enterprise information technology company that helps customers drive digital transformation by "unlocking value from all of their data," HPE delivers unique, open, and intelligent technology solutions, per the GHP. It works to create a consistent experience across all clouds and edges, to help customers develop new business models, engage in new ways, and increase operational performance. HPE has a long Houston pedigree, as Hewlett Packard merged with Compaq Computers in 2002. The company was founded in 2015 following the separation from HP, Inc., and is currently ranked 109 on the list of Fortune 500 companies.

Texas is already the site of HPE locations in Austin, Plano, and Houston. It currently operates major product development, services, manufacturing, and lab facilities in Houston and Austin.

The Houston move would no doubt be a boon to the local economy and create myriad jobs in the sector.

"As we look to the future, our business needs, opportunities for cost savings, and team members' preferences about the future of work, we are excited to relocate HPE's headquarters to the Houston region," said Antonio Neri, CEO of HPE, in a release. "Houston is an attractive market to recruit and retain future diverse talent and where we are currently constructing a state-of-the-art new campus. We look forward to continuing to expand our strong presence in the market."

Abbott applauded the move in a statement, noting, "We are excited that Hewlett Packard Enterprise has chosen to call Texas home, and I thank them for expanding their investment in the Lone Star State by relocating their headquarters to the Houston region. Hewlett Packard Enterprise joins more than 50 Fortune 500 companies headquartered in the Lone Star State, including 22 in the Houston area alone. That is because Texas offers the best business climate in the nation. Our low taxes, high quality of life, top-notch workforce, and tier one universities create an environment where innovative companies like HPE can flourish. We look forward to a successful partnership with HPE, as together we build a more prosperous future for Texas."

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This article originally ran on CultureMap.

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Pharma giant considers Houston for $1B manufacturing campus

in the works

Another pharmaceutical giant is considering Houston’s Generation Park for a manufacturing hub.

According to a recent filing with the Texas Jobs, Energy, Technology and Innovation (JETI) program, Bristol Myers Squibb Co. is considering the northeast Houston management district for a new $1 billion multi-modal pharmaceutical manufacturing campus.

If approved, the campus, known as Project Argonaut, could create 489 jobs in Texas by 2031. Jobs would include operations technicians, engineering roles, administrative and management roles, production specialists, maintenance support, and quality control/assurance. The company predicts annual average wages for these positions to be around $96,000, according to the filing.

The project currently includes the 600,000-square-foot facility, but according to the filing, Bristol Myers Squibb “envisions this site growing in scale and capability well beyond its opening configuration."

The Texas JETI program offers companies temporary school property tax limitations in exchange for major capital investment and job creation. E.R. Squibb & Sons LLC applied for a 10-year tax abatement agreement in the Sheldon Independent School District.

The agreement promises a $ 1 billion investment. Construction would begin in 2027 and wrap in 2029.

“The proposed project reflects [Bristol Myers Squibb Co.’s] enduring commitment to bringing innovative medicines to patients and ensuring the long-term supply reliability they depend on,” the filing says. “The proposed project is purpose-built to support and manufacture medicines spanning multiple therapeutic areas and modalities, positioning the site as a long-term launch and commercial campus for decades to come. These medicines will provide therapies to the [Bristol Myers Squibb Co.’s] patients located in markets both nationally and internationally.”

The Fortune 100 company is considering 16 other cities for the new manufacturing facility in the Central and Eastern markets in the U.S. According to the Houston Chronicle, Bristol Myers Squibb Co is still in the “evaluation process” for its potential manufacturing site.

Last fall, Eli Lilly and Co. selected Generation Park for its $6.5 billion manufacturing plant. More than 300 locations in the U.S. competed for the factory. Read more here.

Houston health tech co. lands NIH grant for AI cancer prediction tool

fresh funding

Houston-based CellChorus and Stanford Medicine were recently awarded a Phase I Small Business Innovation Research grant for the company's AI platform to test how certain cancer patients will respond to therapies.

The funding comes from the National Cancer Institute of the National Institutes of Health. According to a filing, the grant totaled just under $400,000.

CellChorus, which spun out from the University of Houston’s Technology Bridge, has developed TIMING (Time-lapse Imaging Microscopy In Nanowell Grids), which analyzes the behavior of thousands of individual immune cells over time and can identify early indicators of treatment success or failure.

The company will work with Stanford's Dr. David Miklos and Dr. Saurabh Dahiya, who have built the Bone Marrow Transplantation and Cell Therapy Biobank. The biobank manages and stores biological samples from patients treated at their clinic and in clinical trials.

"Predicting which patients will achieve durable responses after CAR-T therapy remains one of the most important challenges in the field,” Miklos said in a news release. “We aim to uncover functional cellular signatures that can guide treatment decisions and improve patient outcomes.”

The project will specifically profile cells from patients with relapsed/refractory large B-cell lymphoma (r/rLBCL). According to CellChorus, only about half of r/rLBCL patients who receive CAR-T therapy "achieve a durable, long-term remission." Others do not respond to therapy or experience relapse.

“The sooner we know whether a cancer therapy is working, the better. To maximize patient benefit, we need technology that can provide a robust and early prediction of response to therapy. The technology needs to be scalable, cost-efficient, and capable of rapid turnaround times,” Rebecca Berdeaux, chief scientific officer of CellChorus, added in the release. “We are excited to work with Drs. David Miklos and Saurabh Dahiya and their colleagues on this very important project.”

CellChorus has previously received SBIR grants from federal agencies, including a $2.5 million award in 2024 from its National Center for Advancing Translational Sciences (NCATS) and a $2.3 million SBIR Fast-Track award from the National Institute of General Medical Sciences in 2023.

Houston museum showcases America's founding documents in rare exhibit

Experience History

As the United States prepares to celebrate its 250th birthday, Houstonians have a chance to see rare documents from the founding of the nation. Freedom Plane National Tour: Documents That Forged a Nation, presented by the National Archives Foundation, will be on display at the Houston Museum of Natural Science through Monday, May 25.

The collection includes a rare engraving of the original Declaration of Independence; official Oaths of Allegiance signed by George Washington, Aaron Burr, and Alexander Hamilton; a draft of the Bill of Rights; the Treaty of Paris, the documented that recognized America's independence from Great Britain; and the tally of votes approving the Constitution.

The National Archives specifically chose Houston as one of only eight cities in the country to host the exhibit as a means to help the documents reach a wider audience outside of the main hub of semiquincentennial events in New England and the Washington, D.C. area.

"One of the things we decided when we put the tour together because we wanted to be off the East Coast," said Patrick Madden, CEO of the National Archives Foundation, who was onsite for the exhibit's opening in Houston. "There's a lot of 250th celebration stuff happening in the original 13 colonies. How do we get it to major markets where larger numbers of people can see it? So in the case of Houston, obviously, [is a] major market in this part of the country, but also we've partnered with the museum twice before with National Archives exhibits, so we knew that they would be up to the task of handling the exhibit and the crowds."

The star of the collection is a rare engraving of the original Declaration of Independence. Secretary of State and future president John Quincy Adams commissioned 200 exact replicas of the document from engraver William J. Stone in 1823. Less than 50 now remain. Madden joyfully pointed out that there are errors in this document, a potent reminder that the men who forged a nation made mistakes.

"There's a couple of typos in it where they had to make corrections," said Madden. "So even the founders, you know, they're all human. That resonates because here these people are making this move against the most powerful nation in the world and putting their lives on the line for a country based on ideas."

Other impressive parts of the collection include official Oaths of Allegiance signed by George Washington, Aaron Burr, and Alexander Hamilton, as well as one of the drafts of the Bill of Rights. Many states would not ratify the Constitution until certain rights were included in the document, leading to Washington going on a national tour assuring state leaders enshrining protections was first on the list. The draft copy on display specifically shows the First Amendment in progress.

Houston is the fourth stop on the exhibition's tour, which will take the documents to Denver, Miami, Dearborn, and Seattle through the summer. Freedom Plane is just one part of a larger patriotic celebration at the HMNS, which includes a film series celebrating American science and culture and general Americana decoration throughout the main hall.

Admission to Freedom Plane is free to the public, but separate from general admission to the museum. Space is limited, and passes are available on a first-come, first-serve basis. Non-members should expect long waits or the possibility that the day's passes are sold out. Only museum members can reserve passes for specific times. Flash photography is prohibited due to the fragile nature of the documents.

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This article originally appeared on CultureMap.com.