With Southwest and Allegiant doubling down on Hobby Airport, the travel hub continues to grow. Image via fly2houston.com

In the estimation of frequent flier Chris Martin, Houston's continually expanding William P. Hobby Airport soars as an "exciting and excellent" hub for business travelers.

Martin is senior vice president of global business development in the Houston office of travel agency Wings Travel Management and one of the leaders of the Houston-based Texas Business Travel Association. He says Hobby Airport's location — seven miles southeast of downtown Houston — and its low-cost flight options hold great appeal for business travelers, especially those with tight travel budgets. And that appeal continues to grow, thanks in part to initiatives at Hobby undertaken by Southwest and Allegiant airlines.

On January 8, Dallas-based Southwest, the No. 1 carrier at Hobby as measured by passenger traffic, unveiled a $125 million, 240,000-square-foot maintenance complex at the airport. It's the largest maintenance facility in Southwest's network. The complex includes a 140,000-square-foot hangar for aircraft maintenance.

"The new hangar continues to showcase our dedication to Houston," Southwest spokesman Dan Landson says. "We've grown continuously over the last several years, and we see more growth in our future, which the hangar will help facilitate."

Southwest's new maintenance complex speeds up airline operations in Houston and helps "get travelers on their way more quickly," Landson says.

At the public debut of the maintenance complex, Southwest Chairman and CEO Gary Kelly told reporters that the airline plans to add a "significant" number of flights at Hobby over the next five to 10 years. He suggested that Houston's beefed-up flight schedule could include brand-new routes to South America.

"We see a lot of opportunity to continue growing," Landson says, "and linking Houston to the places that our customers want to go — whether domestically or internationally."

Today, Southwest offers nearly 200 flights a day from Hobby to almost 70 destinations in the U.S., Mexico, the Caribbean, and Latin America. Hobby opened a $156 million, five-gate international concourse in October 2015.

Six days after Southwest took the wraps off its new maintenance complex, low-cost airline Allegiant said that beginning this May, it's launching seasonal twice-weekly service at Hobby with nonstop flights to Asheville, North Carolina; Destin-Fort Walton Beach, Florida; Knoxville, Tennessee; and Savannah, Georgia. No airlines at Hobby currently serve those destinations.

Allegiant will become the fourth airline to operate at Hobby. Aside from Southwest, American and Delta airlines currently fly out of Hobby, but Southwest is the only one with international service. Last year, JetBlue shifted its Houston operations from Hobby to the larger George Bush Intercontinental Airport.

In 2018, Hobby served almost 14.48 million passengers, up 7.7 percent from 2017 and surpassing 14 million for the first time. Figures for 2019 aren't available yet.

Any increase in passenger traffic at Hobby would certainly be propelled by time-constrained business travelers. In a ranking released January 29 by personal finance website FinanceBuzz, Hobby flies into the top spot on the list of the best U.S. airports if you're running late for a departing flight. To come up with the ranking, FinanceBuzz looked at data for the country's 45 busiest airports.

FinanceBuzz says Hobby's low average wait time at security checkpoints, just under 14 minutes, contributed to its No. 1 ranking.

"The chances of catching Hobby at its busiest are pretty low, and its relatively small number of departing passengers each day helps the airport from getting bogged down with too many travelers," FinanceBuzz reports. "While it's lower percentage of on-time flights might hinder those who are punctual, [this] can be the difference between catching or missing a flight for those running late."

By comparison, Bush Intercontinental ranked eighth on FinanceBuzz's list of the worst U.S. airports if you're running late. It's weighed down by an average 25-minute wait at security checkpoints, according to FinanceBuzz.

"Once you get through security, you've got the sixth-largest terminal on our list to navigate, which puts this airport as one of the worst for late travelers," FinanceBuzz reports of Bush Intercontinental.

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CultureMap Emails are Awesome

7+ can't-miss Houston business and innovation events in June 2026

where to be

Editor's note: The FIFA World Cup comes to Houston this month, joined by major energy conferences and a lineup of fan-favorite, recurring events. Here’s what not to miss and how to register. Please note: this article may be updated to add more events.


June 1-4 — CLEANPOWER 2026 Conference and Exhibition

CLEANPOWER unites policymakers, experts, and corporate leaders to solve the challenges that none can solve alone. This must-attend, four-day conference is packed with cutting-edge discussions about wind, solar, storage, and transmission; dealmaking; networking; and fun.

This event begins June 1 at the George R. Brown Convention Center. Register here.

June 2 — Humans of Healthcare

Houston Methodist Center for Innovation will present its quarterly speaker series, Humans of Healthcare. The series will feature a panel of experts who will share about their career paths and discuss the nuances of the health care industry. This month's session will focus on today’s nursing landscape, the industry’s expectations of nurses and what career paths are possible in the field.

The event is Tuesday, June 2, from 5-6:30 p.m. at the Ion. Register here.

June 9 — Greentown Go Make Kickoff

Head to the Ion to celebrate the Greentown Go Make 2026 cohort. The open-innovation program with Shell Catalysts & Technologies and Technip Energies focuses on catalytic solutions for industrial decarbonization and the energy transition. Hear pitches from the founders and network with a select group of startups while enjoying food and drink.

This event is Tuesday, June 9, from 5:30-8 p.m. Register here.

June 9-10 — Texas Brain Economy Summit

The Center for Houston’s Future and UTMB are bringing the Texas Brain Economy Summit back to Houston this summer to continue to position the region as a global leader in brain health. Expect to hear from leaders of global institutions, including the World Economic Forum, U.S. Chamber of Commerce, McKinsey Health Institute, Global Brain Economy Initiative, Davos Alzheimer’s Collaborative, Business Collaborative for Brain Health (UsAgainstAlzheimer’s), Rice University, Memorial Hermann, MD Anderson and many others. Read InnovationMap's full preview of the event here.

This event begins Tuesday, June 9. Purchase tickets here.

June 10 — MIT Future of Healthcare Technology Forum

The MIT Club of South Texas will host an in-person forum to explore how innovation, government and policy are changing the healthcare industry. The event will feature MIT alumni and Houston healthcare leaders, including Dr. Tim Boone, dean of the Texas A&M School of Engineering Medicine; Cynthia Reinhart-King, chair of bioengineering at Rice University; Dr. Tony Lin, CEO and chairman emeritus of Kelsey-Seybold Clinic; and others.

This event is Wednesday, June 10, from 5:15-8:30 p.m. at the TAMU EnMed Building. Register here.

June 11 — Goals & Gigawatts: Houston Energy & Climate Week The Power of & Kickoff Party

Come watch the Mexico City FIFA opening match while celebrating energy and innovation at the Goals & Gigawatts Kickoff Party. The event will feature food, drinks, and a showcase on Houston Energy & Climate Week. Learn what to expect and how to get involved in HECW before closing the night with a DJ and karaoke.

This event is Thursday, June 11, from 1:30-6:30 p.m. Find more information here.

June 16-17 — Energy Projects Conference & Expo

The Energy Projects Conference & Expo (EPC Show) is the largest event in North America for professionals working at the heart of major energy projects. The essential event for engineering, construction, commissioning, operations and maintenance across multiple energy sectors brings together five leading conferences under one roof. Conference subjects span LNG exporting, hydrogen and ammonia, midstream, petrochem and refining, and sustainable aviation fuels.

This event begins June 16 at George R. Brown Convention Center. Register here.

June 25 – NASA Tech Talk

Every fourth Thursday of the month, NASA experts, including longtime engineer Montgomery Goforth, present on technology development challenges NASA’s Johnson Space Center and the larger aerospace community are facing, and how they can be leveraged by Houston’s innovation community. Stick around after for drinks and networking at Second Draught.

This event is Thursday, June 25, from 6-7 p.m. at the Ion. Register here.

Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”