The analysis cites Amazon, Apple, and Tesla as three of the major employers in Texas pursuing AI initiatives. Photo via Getty Images

If internet search volume is an accurate barometer, Texas is a hotbed for interest in artificial intelligence jobs.

An analysis by Agility Writer, whose technology helps users produce AI-generated content, shows Texas ranks second among the states with the highest monthly search volume for AI-related jobs. The analysis puts Texas’ monthly search volume at 1,300, with California sitting in first place at 1,900 monthly searches.

“As the AI revolution continues to gain momentum, the geographic distribution of interest in AI careers is likely to evolve further, with states investing in AI education and fostering supportive ecosystems poised to reap the benefits of this transformative technology,” says Adam Yong, CEO of Agility Writer.

The analysis cites Amazon, Apple, and Tesla as three of the major employers in Texas pursuing AI initiatives.

Dice.com, a search engine for tech jobs, says AI roles that are in high demand include machine learning engineer, data scientist, AI research scientist, and robotics engineer.

“Looking forward, the demand for AI professionals is expected to intensify as technologies continue to advance and integrate into everyday business processes and consumer products. AI is not just creating jobs but also transforming them, requiring workers to adapt by gaining new skills,” says Dice.com.

A January 2024 report from career platform LinkedIn found that AI consultant and AI engineer are two of the 25 fastest-growing jobs in the U.S. this year. Most of these roles are concentrated in San Francisco, New York City, Washington, D.C.-Baltimore, and Boston, according to the report.

On the flip side, some analysts predict millions of jobs will be affected by or even lost to AI. For example, research from investment banking giant Goldman Sachs indicates roughly two-thirds of U.S. occupations “are exposed to some degree of automation by AI.”

A study released in 2023 by Chamber of Commerce, a business research company, anticipates as many as 12 percent of Houston-area workers could lose their jobs by 2027 due to AI.

"AI and technology in general may be taking certain jobs away, and yet we also see how it is changing the nature of jobs and even organizations and professions. In the ever-changing arena of AI, employees, job-seekers, and students will continue to adapt and learn new job skills that align with and anticipate workforce needs,” AI expert Fred Oswald, the Herbert S. Autrey Chair in Social Sciences at Rice University and a professor of psychological sciences, said in a 2023 news release.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.