Mayor Sylvester Turner and other local leaders joined the stage for the Ten Across summit in Houston this week. Photo by Natalie Harms/InnovationMap

Houston has an integral role to play in the energy transition, and that role was thoroughly discussed at a recent conference taking place in the Bayou City.

This week, Houston hosted the 10X Summit: The Future Is Here, an event by Ten Across — an organization that focuses on social, economic, and climate change issues across the region around Interstate 10 from Los Angeles to Jacksonville. The three-day conference featured guest speakers who spoke to resiliency, water, the future of energy, and more.

Among these speakers included a handful of Houston researchers, political figures, and innovators — and much of their conversations overlapped related topics and themes, from Hurricane Harvey's legacy and impact on the business community to the role the city will play in the energy transition.

When it comes to the energy transition, here are the key messages Houston leaders shared with 10X attendees.

The energy transition can't happen without Houston

The topic of the energy transition came up right out of the gate for the summit. At the welcome reception on Tuesday, Bobby Tudor, CEO of Artemis Energy Partners and founder and former CEO of Tudor, Pickering, Holt & Co., spoke to the evolution of the industry and how Houston is a major factor in the energy transition's success.

“I don’t think (the energy transition) is going to happen without (Houston)," Tudor says at the fireside chat with Wellington Reiter, executive director of Ten Across. "There's a notion that the transition is inevitable. It’s inevitable — only if our technology continues to advance and improve, only if new assets get deployed, only if capital supports it, and only if the people who know and understand the energy systems are leaning in to make it happen.”

For Tudor, who served as chair of the Greater Houston Partnership in 2020 and made it his mission to communicate the importance of industry evolution during his tenure, Houston businesses motivated by opportunities in business should be looking at the energy transition.

“We’re very good in Houston that, when we see a dollar bill lying on the ground, we bend over and pick it up. Right now, there’s fantastic opportunity in the energy transition space," he says. "We have both a responsibility and an opportunity to be the leaders in the global energy transition.”

Mayor Sylvester Turner in his chat with Reiter on Thursday addressed how some might think that Houston — a headquarters for some of the biggest oil and gas giants — might not be the right city to lead a cleaner energy system, but Turner argued that's exactly why it has to happen here.

“We are the energy capital of the world," he says. "The reality is we have some of the largest greenhouse gas emitters principally located right here in Houston. To the extent of leading an energy transition, the impact is not just locally. The impact is globally.”

Barbara Burger, former president of Chevron Technology Ventures and an energy tech startup adviser, explained how integral the relationship between the energy industry and Houston is.

“As the energy system evolves, so does Houston," she says. “I think it’s our opportunity to lose."

The role of corporate incumbents 

Burger's discussion, which took place on Wednesday, spoke to the role of incumbents — corporations that have been operating in the energy industry for decades — in the transition. She explained how the process can't move forward without these parties.

“The incumbents need to be a part of the energy transition. There are parts of our society that don’t want them to be, and I find that unfortunate," she says. "For one, we’re not going to decarbonize the energy system unless they are a part of it. Two, there are a lot of skills and capabilities and assets in the incumbents to do that.

"What I don’t think the incumbents will do is they won’t lead it," she continues. "Many will be leaders in the new energy system, but they won’t be the ones first up the hill.”

Burger compares the energy and the automotive industries. Tesla acted as a disruptor to major auto companies, and then they followed suit. The disruptors and catalysts the energy industry will be a combination of startups, investors, governments, universities, and employee bases.

“We’re not going to throw away the current energy system," she says. "We’re going to evolve it and repurpose it.”

Houston has the ingredients

Tudor addressed the existing infrastructure — from physical pipes to expertise and workforce — that Houston has, which makes for an ideal location for innovation and progress in the transition.

“For a lot of reasons, it’s very clear that unless Houston leans in, we’re not going to find the solutions we need to transition our energy systems to much lower CO2 emissions," he says.

The GHP established the Houston Energy Transition Initiative in 2021 to concentrate Houston efforts within the future of energy. Tudor says this initiative is focused on what can be done now in town — attracting clean energy startups, developing a hydrogen hub, building facilities for green hydrogen production — to lead to a better future.

“We want to look up 20 years from now and find Houston is still — if not more than ever — the energy capital of the world," he says. "We believe that energy systems globally in 20 years will look quite different from how they look today. And that means Houston will look very different from how it looks today."

Burger emphasized some of the challenges — as well as opportunities — the city has considering its long history within the sector.

“Houston has benefitted from a vibrant, strong U.S. energy industry,” she says. “Keeping strong companies and keeping Houston attractive for the energy business is critical.”

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."