Mayor Sylvester Turner and other local leaders joined the stage for the Ten Across summit in Houston this week. Photo by Natalie Harms/InnovationMap

Houston has an integral role to play in the energy transition, and that role was thoroughly discussed at a recent conference taking place in the Bayou City.

This week, Houston hosted the 10X Summit: The Future Is Here, an event by Ten Across — an organization that focuses on social, economic, and climate change issues across the region around Interstate 10 from Los Angeles to Jacksonville. The three-day conference featured guest speakers who spoke to resiliency, water, the future of energy, and more.

Among these speakers included a handful of Houston researchers, political figures, and innovators — and much of their conversations overlapped related topics and themes, from Hurricane Harvey's legacy and impact on the business community to the role the city will play in the energy transition.

When it comes to the energy transition, here are the key messages Houston leaders shared with 10X attendees.

The energy transition can't happen without Houston

The topic of the energy transition came up right out of the gate for the summit. At the welcome reception on Tuesday, Bobby Tudor, CEO of Artemis Energy Partners and founder and former CEO of Tudor, Pickering, Holt & Co., spoke to the evolution of the industry and how Houston is a major factor in the energy transition's success.

“I don’t think (the energy transition) is going to happen without (Houston)," Tudor says at the fireside chat with Wellington Reiter, executive director of Ten Across. "There's a notion that the transition is inevitable. It’s inevitable — only if our technology continues to advance and improve, only if new assets get deployed, only if capital supports it, and only if the people who know and understand the energy systems are leaning in to make it happen.”

For Tudor, who served as chair of the Greater Houston Partnership in 2020 and made it his mission to communicate the importance of industry evolution during his tenure, Houston businesses motivated by opportunities in business should be looking at the energy transition.

“We’re very good in Houston that, when we see a dollar bill lying on the ground, we bend over and pick it up. Right now, there’s fantastic opportunity in the energy transition space," he says. "We have both a responsibility and an opportunity to be the leaders in the global energy transition.”

Mayor Sylvester Turner in his chat with Reiter on Thursday addressed how some might think that Houston — a headquarters for some of the biggest oil and gas giants — might not be the right city to lead a cleaner energy system, but Turner argued that's exactly why it has to happen here.

“We are the energy capital of the world," he says. "The reality is we have some of the largest greenhouse gas emitters principally located right here in Houston. To the extent of leading an energy transition, the impact is not just locally. The impact is globally.”

Barbara Burger, former president of Chevron Technology Ventures and an energy tech startup adviser, explained how integral the relationship between the energy industry and Houston is.

“As the energy system evolves, so does Houston," she says. “I think it’s our opportunity to lose."

The role of corporate incumbents 

Burger's discussion, which took place on Wednesday, spoke to the role of incumbents — corporations that have been operating in the energy industry for decades — in the transition. She explained how the process can't move forward without these parties.

“The incumbents need to be a part of the energy transition. There are parts of our society that don’t want them to be, and I find that unfortunate," she says. "For one, we’re not going to decarbonize the energy system unless they are a part of it. Two, there are a lot of skills and capabilities and assets in the incumbents to do that.

"What I don’t think the incumbents will do is they won’t lead it," she continues. "Many will be leaders in the new energy system, but they won’t be the ones first up the hill.”

Burger compares the energy and the automotive industries. Tesla acted as a disruptor to major auto companies, and then they followed suit. The disruptors and catalysts the energy industry will be a combination of startups, investors, governments, universities, and employee bases.

“We’re not going to throw away the current energy system," she says. "We’re going to evolve it and repurpose it.”

Houston has the ingredients

Tudor addressed the existing infrastructure — from physical pipes to expertise and workforce — that Houston has, which makes for an ideal location for innovation and progress in the transition.

“For a lot of reasons, it’s very clear that unless Houston leans in, we’re not going to find the solutions we need to transition our energy systems to much lower CO2 emissions," he says.

The GHP established the Houston Energy Transition Initiative in 2021 to concentrate Houston efforts within the future of energy. Tudor says this initiative is focused on what can be done now in town — attracting clean energy startups, developing a hydrogen hub, building facilities for green hydrogen production — to lead to a better future.

“We want to look up 20 years from now and find Houston is still — if not more than ever — the energy capital of the world," he says. "We believe that energy systems globally in 20 years will look quite different from how they look today. And that means Houston will look very different from how it looks today."

Burger emphasized some of the challenges — as well as opportunities — the city has considering its long history within the sector.

“Houston has benefitted from a vibrant, strong U.S. energy industry,” she says. “Keeping strong companies and keeping Houston attractive for the energy business is critical.”

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”