Startup School

5 books every budding entrepreneur needs to read

Before you even start thinking about starting your own company, read these books. Photo by Utamaru Kido/Getty Images

You thought you were done with homework, but, if you're an entrepreneur looking to start a company, that's not the case. The startup world is a lot of fun, but also a lot of work and preparation.

So, what kind of homework should you do? Unfortunately, watching Shark Tank and HBO's Silicon Valley can only take you so far. You need to know about pre-money valuations, convertible notes, liquidation preferences, control provisions, and so much more. Fortunately, there are plenty of books to get you up to speed. Yes, books — do you remember those? Turns out plain old books can be very useful if you're looking to get involved with the even the highest tech parts of the startup world. So here are five books to get you started.

The Launch Pad: Inside Y Combinator, Silicon Valley's Most Exclusive School for Startups

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As a startup founder, you'll need to know what Y Combinator is, how it works, what the people are like, and how great founders and mentors conduct themselves. This book offers a behind the scenes look at the most elite startup incubator/accelerator. Why is it the most elite? Because it keeps producing unicorns (companies valued at over $1 billion) — think AirBnb, Dropbox, Twitch, Stripe. With this book, you'll really get a sense of the day to day conversations and challenges that startups face. It is also just a really entertaining book and a great starting point.

Venture Deals: Be Smarter Than Your Lawyer and Venture Capitalist

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After reading Launch Pad, it is time to get down to business. Venture Deals is a fairly in-depth breakdown of the relationship between investors and startup founders. It runs through typical VC titles, processes, and incentives. Perhaps most importantly, it goes into the economic and control provisions of the term sheet. You'll want a pen and paper to take plenty of notes when going through this one. Do not expect this book to always be fun, but do expect to learn a lot. If you can make it through this one and really absorb what is being said then you might actually be serious about the startup world, so good job.

Measure What Matters: How Google, Bono, and the Gates Foundation Rock the World with OKRs

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Whether you'll be a founder, investor, reporter, or just want to be a successful person, you need to set lofty goals, write them down, share them, and stick to them. OKR stands for objectives and key result. This book is less about startups and more about pushing yourself to achieve more. OKRs force you to break down your goals in metrics that can be tracked. For example, I knew I wanted to meet with hundreds of startups per year for my investment job. But how many exactly? How do I set a goal for that? Simple — just say you need to meet with at least two startups per day for a least one hour. That means at least 10 startups per week (five working days), or over 40 per month. Set lofty goals, so that you fail to achieve 30 percent of them.

Startup CEO: A Field Guide to Scaling Up Your Business

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Time to step inside the shoes of the CEO — must be nice to be in charge, right? I'm sure it is nice in some ways, but it is also an unbelievable amount of work. This book goes through every last detail — in detail. You may feel overwhelmed at times, but you might also feel ready to manage a company. There is much more to managing a company than can be found in a single book, but this is a great breakdown of the day-to-day activities. It has tips on how to be organized, prioritize time, grow your key employees, and interact with the board of directors. Sure, you'll still need to build a great product that customers want, and you'll still need to have great interpersonal and communication skills, but at least this book describes the details of how to operate.

​Zero to One: Notes on Startups, or How to Build the Future​

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The final book in this short list will drive you to think big — and think differently. Think about building a dominating monopoly. Yes, monopolies are a good thing when you're the one making the business. I hope that concept is not too upsetting, but you should be ruthless when you are out there competing. That means giving your customers something amazing that your competition can't even compete with. If you think about it, the big tech companies pretty much dominate at least one market. Google has search and maps. Facebook, since owning Instagram, has social media. Amazon has logistics. If you're going to start a startup you should aim to be 10 times better than any competition in one key way. You want to clearly differentiate your product from your competition. Zero to One teaches you how to think that way, and so much more.

So, there you have it. I think these five books will give you a good starting point. There are a dozen or more other books you should also read about innovating, investing, and managing, but you must start somewhere. This list gives you a little bit of everything to get you started.

Now, you just have to actually start.

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Mark Friday is an associate leading venture capital investments at Houston-based Cathexis Holdings LP.

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Building Houston

 
 

A Rice research team is tapping into materials science to better understand Alzheimer’s disease, a UH professor is developing a treatment for hereditary vision loss, and a BCM researcher is looking at stress and brain cancer. Photo by Gustavo Raskosky/Rice University

Research, perhaps now more than ever, is crucial to expanding and growing innovation in Houston — and it's happening across the city right under our noses.

In InnovationMap's latest roundup of research news, three Houston institutions are working on life-saving health care research thanks to new technologies.

Rice University scientists' groundbreaking alzheimer's study

Angel Martí (right) and his co-authors (from left) Utana Umezaki and Zhi Mei Sonia He have published their latest findings on Alzheimer’s disease. Photo by Gustavo Raskosky/Rice University

According to the Centers for Disease Control and Prevention, Alzheimer’s disease will affect nearly 14 million people in the U.S. by 2060. A group of scientists from Rice University are looking into a peptide associated with the disease, and their study was published in Chemical Science.

Angel Martí — a professor of chemistry, bioengineering, and materials science and nanoengineering and faculty director of the Rice Emerging Scholars Program — and his team have developed a new approach using time-resolved spectroscopy and computational chemistry, according to a news release from Rice. The scientists "found experimental evidence of an alternative binding site on amyloid-beta aggregates, opening the door to the development of new therapies for Alzheimer’s and other diseases associated with amyloid deposits."

Amyloid plaque deposits in the brain are a main feature of Alzheimer’s, per Rice.

“Amyloid-beta is a peptide that aggregates in the brains of people that suffer from Alzheimer’s disease, forming these supramolecular nanoscale fibers, or fibrils” says Martí in the release. “Once they grow sufficiently, these fibrils precipitate and form what we call amyloid plaques.

“Understanding how molecules in general bind to amyloid-beta is particularly important not only for developing drugs that will bind with better affinity to its aggregates, but also for figuring out who the other players are that contribute to cerebral tissue toxicity,” he adds.

The National Science Foundation and the family of the late Professor Donald DuPré, a Houston-born Rice alumnus and former professor of chemistry at the University of Louisville, supported the research, which is explained more thoroughly on Rice's website.

University of Houston professor granted $1.6M for gene therapy treatment for rare eye disease

Muna Naash, a professor at UH, is hoping her research can result in treatment for a rare genetic disease that causes vision loss. Photo via UH.edu

A University of Houston researcher is working on a way to restore sight to those suffering from a rare genetic eye disease.

Muna Naash, the John S. Dunn Endowed Professor of biomedical engineering at UH, is expanding a method of gene therapy to potentially treat vision loss in patients with Usher Syndrome Type 2A, or USH2A, a rare genetic disease.

Naash has received a $1.6 million grant from the National Eye Institute to support her work. Mutations of the USH2A gene can include hearing loss from birth and progressive loss of vision, according to a news release from UH. Naash's work is looking at applying gene therapy — the introduction of a normal gene into cells to correct genetic disorders — to treat this genetic disease. There is not currently another treatment for USH2A.

“Our goal is to advance our current intravitreal gene therapy platform consisting of DNA nanoparticles/hyaluronic acid nanospheres to deliver large genes in order to develop safe and effective therapies for visual loss in Usher Syndrome Type 2A,” says Naash. “Developing an effective treatment for USH2A has been challenging due to its large coding sequence (15.8 kb) that has precluded its delivery using standard approaches and the presence of multiple isoforms with functions that are not fully understood."

BCM researcher on the impact of stress

This Baylor researcher is looking at the relationship between stress and brain cancer thanks to a new grant. Photo via Andriy Onufriyenko/Getty Images

Stress can impact the human body in a number of ways — from high blood pressure to hair loss — but one Houston scientist is looking into what happens to bodies in the long term, from age-related neurodegeneration to cancer.

Dr. Steven Boeynaems is assistant professor of molecular and human genetics at Baylor College of Medicine. His lab is located at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and he also is a part of the Therapeutic Innovation Center, the Center for Alzheimer’s and Neurodegenerative Diseases, and the Dan L Duncan Comprehensive Cancer Center at Baylor.

Recently, the Cancer Prevention and Research Institute of Texas, or CPRIT, awarded Boeynaems a grant to continue his work studying how cells and organisms respond to stress.

“Any cell, in nature or in our bodies, during its existence, will have to deal with some conditions that deviate from its ideal environment,” Boeynaems says in a BCM press release. “The key issue that all cells face in such conditions is that they can no longer properly fold their proteins, and that leads to the abnormal clumping of proteins into aggregates. We have seen such aggregates occur in many species and under a variety of stress-related conditions, whether it is in a plant dealing with drought or in a human patient with aging-related Alzheimer’s disease."

Now, thanks to the CPRIT funding, he says his lab will now also venture into studying the role of cellular stress in brain cancer.

“A tumor is a very stressful environment for cells, and cancer cells need to continuously adapt to this stress to survive and/or metastasize,” he says in the release.

“Moreover, the same principles of toxic protein aggregation and protection through protein droplets seem to be at play here as well,” he continues. “We have studied protein droplets not only in humans but also in stress-tolerant organisms such as plants and bacteria for years now. We propose to build and leverage on that knowledge to come up with innovative new treatments for cancer patients.”

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